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Publication Date: 2007-12-21
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Lenz Souza, M. I., Ramírez Benavides, G. F., & Uribe Velásquez, L. F. (2007). Role of the insulin-like growth factor (IGF-1) in the ovaric function regulation. Biosalud, 6, 149–159. Retrieved from https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/5851
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Abstract
Numerous growth factors and cytokines have been reported to suppress granulosa cell estradiol production in vitro, but the association of expression of such factors in vivo with follicle health status and their physiological significance are not clear. The purpose of this review is to show several studies that support the physiological importance in vivo and in vitro of Insulin-like Growth Factor (IGF-1), a peptidic factor that originates in the teca cells and that by different means acts upon follicular growth, development and maturation functions, as well as their products in direct interactions with other gonadotropins, gonadal steroids and aromatase in ruminants, horses, pigs and humans. IGF-I plays an important role in gonadotrophin-induced folliculogenesis, ovarian steroidogenesis and luteous body (LB) function. It also modulates pituitary and hypothalamus function. The review also explores the effect of the nutritional status in the circulating IGF-I concentrations and the endocrine role of IGF-1 on the reproductive axis.
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References
Adam C, Findlay PA, Moore AH. Effects of insulin-like growth factor-1 on luteinizing hormone secretion in sheep. Anim. Reprod. Sci. 1998; 50:45-56.
Adam C, Gadd T, Findlay P, Whates D. Insulin-like growth factor (IGF)-I stimulation of luteinizing hormone secretion, IGF-binding proteins (IGFBPs) and expression of mRNAs for IGFs, IGF receptors and IGFBPs in the ovine pituitary gland. J. Endoc. 2000; 166:247-254.
Armstrong D, Baxter G, Hogg C, Woad K. Insulin-like growth factor (IGF) system in the oocyte and somatic cells of bovine preantral follicles. Reproduction 2002; 123:789-797.
Behl R, Pandey R. Effect os recombinant insulin like growth factor-1 on caprine granulosa cell steroidogenesis, in vitro. Small Rum. Res. 1999; 33:165-169.
Berisha B, Schams D. Ovarian function in ruminants. Dom. Anim. Reprod. 2005; 9:305-317.
Félix L. Factores correguladores del crecimiento y diferenciación folicular independiente de gonadotropinas. Disponible en: www.portalveterinaria.com [consultado 23 diciembre 2003].
Ferreira J, Toniolli R, Duarte A, Moreira F, García J. Ação do fator de crescimento semelhante à insulina I (IGF-I) e de suas proteínas ligadoras (IGFBPs) no desenvolvimento folicular de bovinos – Revisão. Rev. Bras. Reprod. Anim. 2002; 26:306-311.
Ginther O, Bergfelt D, Beg M, Kot K. Effect of LH on circulating oestradiol and follicular fluid factor concentrations during follicle deviation in cattle. Reproduction 2001; 122:103-110.
Hammond J. IGF (Insulin-like Growth Factor). In: Knobil E, Neill JD. Encyclopedia of Reproduction. San Diego: Academic Press; 1999. 2:781-789.
Hashizume T, Ohtsuky K, Matsumoto N. Plasma insulin-like growth factor-I concentrations increase during the estrous phase in goats. Dom. Anim. Endoc. 2000; 18:253-263.
Hashizume T, Kumahara A, Fujino M, Okada K. Insulin-like growth factor I enhances gonoadotropinreleasing hormone-stimulated luteinizing hormone release from bovine anterior pituitary cells. Anim. Reprod. Sci. 2002; 70:13-21.
Hastie P, Onagbesan O, Haresign W. Co-expression of messenger ribonucleic acids encoding IGFI, IGF-II, type I and II IGF receptors and IGF-binding proteins (IGBP-1 to -6) during follicular development in the ovary of seasonally anoestrous ewes. Anim. Reprod. Sci. 2004; 84:93-105.
Irving H, Catanzariti K, Master M, Grant P, Owens P, Rodgers R. Insulin-like growth factor binding proteins in follicular fluid from morphologically distinct healthy and atretic bovine antral follicles. Reprod. Fert. Dev. 2003; 15:241-248.
Kadokawa H, Briegel J, Blackberry M, Blache D, Martin G, Adams N. Reproduction and plasma concentrations of leptin, insulin and insulin-like growth factor 1 in growth-hormone-transgenic female sheep before and after artificial insemination. Reprod. Fert. Dev. 2003; 15:47-53.
Kawashima C, Sudo N, Amaya C, Kaneko E, Matsui M, Matsunaga N, et al. The role of the insulinlike growth factor 1 (IGF-1) in development of an estrogen-active dominant follicle during the first follicular wave postpartum in dairy cows. Reprod. Fert. Dev. 2006; 19:242-243.
Khalid M, Basiouni G, Haresign W. Effect of progesterone pre-treatment on steroid secretion rates and follicular fluid insulin-like growth factor-1 concentrations in seasonally anoestrous ewes treated with gonadotrophin releasing hormone. Anim. Reprod. Sci. 1997; 46:69-78.
Khalid M, Haresign W, Luck M. Secretion of IGF-1 by ovine granulosa cells: effects of growth hormone and follicle stimulating hormone. Anim. Reprod. Sci. 2000; 58:261-272.
Khamsi F, Roberge S. Granulosa cells of cumulus oophorus are different from mural granulosa cells in their response to gonadotrophins and insulin-like growth factor-I. J. Endoc. 2001; 170:565-573.
Kim J, Fazleabas A. Growth factors. In: Knobil E, Neill JD. Encyclopedia of Reproduction. San Diego: Academic Press; 1999. 2:573-583.
Kobayashi Y, Jiménez F, Ireland J, Smith G. Evidence of a local negative role for cocaine and amphetamine regulated transcript (CART), inhibins and low molecular weight insulin like growth factor binding proteins in regulation of granulose cell estradiol production during follicular waves in cattle. Reprod. Biol. Endoc. 2006; 4:22-32.
Lucy M. Regulation of ovarian follicular growth by somatotropin and insulin-like growth factors in cattle. J. Dairy Sci. 2000; 83:1635-1647.
McCaffery H, Campbell B, Jelfer E. The effect of IGF-1 on the development of bovine preantral follicles in vitro. Biol. Reprod. 2001; 64:109.
Monget P, Monniaux D. Growth factors and the control of folliculogenesis. J. Reprod. Fert. 1995; 105:321-233.
Monget P, Fabre S, Mulsant P, Lecerf F, Elsen JM, Mazerbourg S, et al. Growth factors and ovarian physiology in domestic animals. Biotechnologie Agron. Soc. Env. 2001; 5 :16-17.
Monniaux D, Huet C, Besnard N, Clément F, Bosc M, Pisselet C, et al. Follicular growth and ovarian dynamics in mammals. J. Reprod. Fert. 1997; 51:3-23.
Monniaux D, Monget P, Besnard N, Huet C, Pisselet C. Growth factors and antral follicular development in domestic ruminants. Theriogenology 1997; 47:3-12.
Nicholas B, Webb R, Hogg C, Baxter G, Goddard C, Armstrong D. Differentiative effects of IGF system components on bovine follicular cells. Biol. Reprod. 2001; 64:166.
Nonaka S, Hashizume T, Horiuchi M, Mikami U, Osawa T, Miyake Y, et al. Origin of plasma insulinlike growth factor-I (IGF-I) during estrus in goats. J. Reprod. Dev. 2003; 49:253-258.
O’Callaghan D, Yaakub H, Hyttel P, Spicer L, Boland M. Effect of nutrition and superovulation on oocyte morphology, follicular fluid composition and systemic hormone concentrations in ewes. J. Reprod. Fert. 2000; 118:303-313.
Onagbesan O, Vleugels B, Buys N, Bruggeman V, Safi M, Decuypere E. Insulin-like growth factors in the regulation of avian ovarian functions. Dom. Anim. Endoc. 1999; 17:299-313.
Peterson A, Ledgard A, Hodgkinson S. The proteolysis of insulin-like growth factor binding proteins in ovine uterine luminal fluid. Reprod. Fert. Dev. 1998; 10:309-314.
Picazo R, López A. Desarrollo folicular en el ovario de la especie ovina. Inv. Agr. Prod. San. Anim. 1995; 10:77-93.
Renaville R, Parmentier I, Hetzel S, Fontaine S, Haezebroeck V, Portetelle D. RIA method for plasma insulin-like growth factor-binding protein-3 quantification in cattle at various physiological situations. Biotech. Agro. Soc. Env. 2001; 5:92.
Richards J, Russell D, Ochsner S, Hsieh M, Doyle K, Falender A, et al. Novel signaling pattways that control ovarian follicular development, ovulation, and luteinization. Rec. Prog. Horm. Res. 2002; 57:195-220.
Roberts A, Al-Hassan M, Fricke P, Echternkamp S. Large variation in steroid concentrations and insulin-like growth factor binding proteins exists among individual small antral follicles collected from within cows at random stages of the estrous cycle. J. Anim. Sci. 2006; 84:2714-2724.
Scaramuzzi R, Campbell B, Downing J, Kendall N, Khalid M, Muñoz M, et al. A review of the effects of supplementary nutrition in the ewe on the concentrations of reproductive and metabolic hormones and the mechanisms that regulate folliculogenesis and ovulation rate. Rep. Nut. Dev. 2006; 46:339-354.
Scaramuzz R, Murray J, Downing J, Campbell B. The effects of exogenous growth hormone on follicular steroid secretion and ovulation rate in sheep. Dom. Anim. Endoc. 1999; 17:269-277.
Schams D, Berisha B, Kosmann M, Einspanier R, Amselgruber W. Possible role of growth hormone, IGFs, and IGF-binding proteins in the regulation of ovarian function in large farm animals. Dom. Anim. Endoc. 1999; 17:279-285.
Sirotkin A, Florkovicová I, Makarevich A, Schaeffer H, Kotwica J, Marnet P, et al. Oxytocin mediates some effects of insulin-like growth factor-I on porcine ovarian follicles. J. Rep. Dev. 2003; 49:141-149.
Spicer L, Chamberlain C. Production of insulin-like growth factor-I by granulosa cels but not thecal cells is hormonally response in cattle. J. Anim. Sci. 2000; 78:2919-2926.
Spicer L, Chamberlain C. Ptroteolysis of insulin-like growth factor binding proteins during preovulatory follicular development in cattle. Dom. Anim. Endoc. 2001; 21:1-15.
Spicer L, Chamberlain C, Maciel S. Influence of gonadotropins on insulin- and insulin-like growth factor-I (IGF-I)-induced steroid production by bovine granulose cells. Dom. Anim. Endoc. 2002; 22:237-254.
Spicer L, Echternkamp S. The ovarian insulin and insulin-like growth factor system with na enphasis on domestic animals. Dom. Anim. Endoc. 1995; 12:223-245.
Spicer L, Echternkamp S, Wong E, Hamilton D, Vernon R. Serum hormones, follicular fluid steroids, insulin-like growth factors and their binding proteins, and ovarian IGF mRNA in sheep with different ovulation rates. J. Anim. Sci. 1995; 73:1152-1163.
Spicer L, Hanrahan J, Zavy M, Enright W. Relationship between ovulation rate and concentrations of insulin-like growth factor-1 in plasma during the estrous cycle in various genotypes of sheep. J. Rep. Fert. 1993; 97:403-409.
Spicer L, Santiago C, Davidson T, Bridges T, Chamberlain C. Follicular fluid concentrations of free insulin-like growth factor (IGF)-I during follicular development in mares. Dom. Anim. Endoc. 2005; 29:573-581.
Stevenson K, Whates D. Insulin-lije growth factors and their binding proteins in the ovine oviduct during the oestrous cycle. J. Rep. Fert. 1996; 108:31-40.
Woad K, Baxter G, Hogg C, Bramley T, Webb R, Armstrong D. Expression of mRNA encoding insulin-like growth factors I and II and the type 1 IGF receptor in the bovine corpus luteum at defined stages of the estrous cycle. J. Rep. Fert. 2000; 120:293-302.
Xia Y, Weiss J, Polack S, Diedrich K, Ortmann O. Experimental sutdy: Intercations of insulin-like growth factor-I, insulin and estradiol with GnRH-stimulated luteinizing hormone release from female rat gonadotrophs. Europ. J. Endoc. 2001;144:73-79.
Zulu V, Nakada K, Sawamukai Y. Insulin-like growth factor-I as a possible hormonal mediator of nutritional regulation in reproduction in cattle. J. Vet. Med. Sci. 2002; 64:657-665.
Zulu V, Sawamukai Y, Nakada K, Kida K, Moriyoshi M. Relationship among insulin-like growth factor-I, blood metabolities and postpartum ovarian function in dairy cows. J. Vet. Med. Sci. 2002; 64:879-885.
Adam C, Gadd T, Findlay P, Whates D. Insulin-like growth factor (IGF)-I stimulation of luteinizing hormone secretion, IGF-binding proteins (IGFBPs) and expression of mRNAs for IGFs, IGF receptors and IGFBPs in the ovine pituitary gland. J. Endoc. 2000; 166:247-254.
Armstrong D, Baxter G, Hogg C, Woad K. Insulin-like growth factor (IGF) system in the oocyte and somatic cells of bovine preantral follicles. Reproduction 2002; 123:789-797.
Behl R, Pandey R. Effect os recombinant insulin like growth factor-1 on caprine granulosa cell steroidogenesis, in vitro. Small Rum. Res. 1999; 33:165-169.
Berisha B, Schams D. Ovarian function in ruminants. Dom. Anim. Reprod. 2005; 9:305-317.
Félix L. Factores correguladores del crecimiento y diferenciación folicular independiente de gonadotropinas. Disponible en: www.portalveterinaria.com [consultado 23 diciembre 2003].
Ferreira J, Toniolli R, Duarte A, Moreira F, García J. Ação do fator de crescimento semelhante à insulina I (IGF-I) e de suas proteínas ligadoras (IGFBPs) no desenvolvimento folicular de bovinos – Revisão. Rev. Bras. Reprod. Anim. 2002; 26:306-311.
Ginther O, Bergfelt D, Beg M, Kot K. Effect of LH on circulating oestradiol and follicular fluid factor concentrations during follicle deviation in cattle. Reproduction 2001; 122:103-110.
Hammond J. IGF (Insulin-like Growth Factor). In: Knobil E, Neill JD. Encyclopedia of Reproduction. San Diego: Academic Press; 1999. 2:781-789.
Hashizume T, Ohtsuky K, Matsumoto N. Plasma insulin-like growth factor-I concentrations increase during the estrous phase in goats. Dom. Anim. Endoc. 2000; 18:253-263.
Hashizume T, Kumahara A, Fujino M, Okada K. Insulin-like growth factor I enhances gonoadotropinreleasing hormone-stimulated luteinizing hormone release from bovine anterior pituitary cells. Anim. Reprod. Sci. 2002; 70:13-21.
Hastie P, Onagbesan O, Haresign W. Co-expression of messenger ribonucleic acids encoding IGFI, IGF-II, type I and II IGF receptors and IGF-binding proteins (IGBP-1 to -6) during follicular development in the ovary of seasonally anoestrous ewes. Anim. Reprod. Sci. 2004; 84:93-105.
Irving H, Catanzariti K, Master M, Grant P, Owens P, Rodgers R. Insulin-like growth factor binding proteins in follicular fluid from morphologically distinct healthy and atretic bovine antral follicles. Reprod. Fert. Dev. 2003; 15:241-248.
Kadokawa H, Briegel J, Blackberry M, Blache D, Martin G, Adams N. Reproduction and plasma concentrations of leptin, insulin and insulin-like growth factor 1 in growth-hormone-transgenic female sheep before and after artificial insemination. Reprod. Fert. Dev. 2003; 15:47-53.
Kawashima C, Sudo N, Amaya C, Kaneko E, Matsui M, Matsunaga N, et al. The role of the insulinlike growth factor 1 (IGF-1) in development of an estrogen-active dominant follicle during the first follicular wave postpartum in dairy cows. Reprod. Fert. Dev. 2006; 19:242-243.
Khalid M, Basiouni G, Haresign W. Effect of progesterone pre-treatment on steroid secretion rates and follicular fluid insulin-like growth factor-1 concentrations in seasonally anoestrous ewes treated with gonadotrophin releasing hormone. Anim. Reprod. Sci. 1997; 46:69-78.
Khalid M, Haresign W, Luck M. Secretion of IGF-1 by ovine granulosa cells: effects of growth hormone and follicle stimulating hormone. Anim. Reprod. Sci. 2000; 58:261-272.
Khamsi F, Roberge S. Granulosa cells of cumulus oophorus are different from mural granulosa cells in their response to gonadotrophins and insulin-like growth factor-I. J. Endoc. 2001; 170:565-573.
Kim J, Fazleabas A. Growth factors. In: Knobil E, Neill JD. Encyclopedia of Reproduction. San Diego: Academic Press; 1999. 2:573-583.
Kobayashi Y, Jiménez F, Ireland J, Smith G. Evidence of a local negative role for cocaine and amphetamine regulated transcript (CART), inhibins and low molecular weight insulin like growth factor binding proteins in regulation of granulose cell estradiol production during follicular waves in cattle. Reprod. Biol. Endoc. 2006; 4:22-32.
Lucy M. Regulation of ovarian follicular growth by somatotropin and insulin-like growth factors in cattle. J. Dairy Sci. 2000; 83:1635-1647.
McCaffery H, Campbell B, Jelfer E. The effect of IGF-1 on the development of bovine preantral follicles in vitro. Biol. Reprod. 2001; 64:109.
Monget P, Monniaux D. Growth factors and the control of folliculogenesis. J. Reprod. Fert. 1995; 105:321-233.
Monget P, Fabre S, Mulsant P, Lecerf F, Elsen JM, Mazerbourg S, et al. Growth factors and ovarian physiology in domestic animals. Biotechnologie Agron. Soc. Env. 2001; 5 :16-17.
Monniaux D, Huet C, Besnard N, Clément F, Bosc M, Pisselet C, et al. Follicular growth and ovarian dynamics in mammals. J. Reprod. Fert. 1997; 51:3-23.
Monniaux D, Monget P, Besnard N, Huet C, Pisselet C. Growth factors and antral follicular development in domestic ruminants. Theriogenology 1997; 47:3-12.
Nicholas B, Webb R, Hogg C, Baxter G, Goddard C, Armstrong D. Differentiative effects of IGF system components on bovine follicular cells. Biol. Reprod. 2001; 64:166.
Nonaka S, Hashizume T, Horiuchi M, Mikami U, Osawa T, Miyake Y, et al. Origin of plasma insulinlike growth factor-I (IGF-I) during estrus in goats. J. Reprod. Dev. 2003; 49:253-258.
O’Callaghan D, Yaakub H, Hyttel P, Spicer L, Boland M. Effect of nutrition and superovulation on oocyte morphology, follicular fluid composition and systemic hormone concentrations in ewes. J. Reprod. Fert. 2000; 118:303-313.
Onagbesan O, Vleugels B, Buys N, Bruggeman V, Safi M, Decuypere E. Insulin-like growth factors in the regulation of avian ovarian functions. Dom. Anim. Endoc. 1999; 17:299-313.
Peterson A, Ledgard A, Hodgkinson S. The proteolysis of insulin-like growth factor binding proteins in ovine uterine luminal fluid. Reprod. Fert. Dev. 1998; 10:309-314.
Picazo R, López A. Desarrollo folicular en el ovario de la especie ovina. Inv. Agr. Prod. San. Anim. 1995; 10:77-93.
Renaville R, Parmentier I, Hetzel S, Fontaine S, Haezebroeck V, Portetelle D. RIA method for plasma insulin-like growth factor-binding protein-3 quantification in cattle at various physiological situations. Biotech. Agro. Soc. Env. 2001; 5:92.
Richards J, Russell D, Ochsner S, Hsieh M, Doyle K, Falender A, et al. Novel signaling pattways that control ovarian follicular development, ovulation, and luteinization. Rec. Prog. Horm. Res. 2002; 57:195-220.
Roberts A, Al-Hassan M, Fricke P, Echternkamp S. Large variation in steroid concentrations and insulin-like growth factor binding proteins exists among individual small antral follicles collected from within cows at random stages of the estrous cycle. J. Anim. Sci. 2006; 84:2714-2724.
Scaramuzzi R, Campbell B, Downing J, Kendall N, Khalid M, Muñoz M, et al. A review of the effects of supplementary nutrition in the ewe on the concentrations of reproductive and metabolic hormones and the mechanisms that regulate folliculogenesis and ovulation rate. Rep. Nut. Dev. 2006; 46:339-354.
Scaramuzz R, Murray J, Downing J, Campbell B. The effects of exogenous growth hormone on follicular steroid secretion and ovulation rate in sheep. Dom. Anim. Endoc. 1999; 17:269-277.
Schams D, Berisha B, Kosmann M, Einspanier R, Amselgruber W. Possible role of growth hormone, IGFs, and IGF-binding proteins in the regulation of ovarian function in large farm animals. Dom. Anim. Endoc. 1999; 17:279-285.
Sirotkin A, Florkovicová I, Makarevich A, Schaeffer H, Kotwica J, Marnet P, et al. Oxytocin mediates some effects of insulin-like growth factor-I on porcine ovarian follicles. J. Rep. Dev. 2003; 49:141-149.
Spicer L, Chamberlain C. Production of insulin-like growth factor-I by granulosa cels but not thecal cells is hormonally response in cattle. J. Anim. Sci. 2000; 78:2919-2926.
Spicer L, Chamberlain C. Ptroteolysis of insulin-like growth factor binding proteins during preovulatory follicular development in cattle. Dom. Anim. Endoc. 2001; 21:1-15.
Spicer L, Chamberlain C, Maciel S. Influence of gonadotropins on insulin- and insulin-like growth factor-I (IGF-I)-induced steroid production by bovine granulose cells. Dom. Anim. Endoc. 2002; 22:237-254.
Spicer L, Echternkamp S. The ovarian insulin and insulin-like growth factor system with na enphasis on domestic animals. Dom. Anim. Endoc. 1995; 12:223-245.
Spicer L, Echternkamp S, Wong E, Hamilton D, Vernon R. Serum hormones, follicular fluid steroids, insulin-like growth factors and their binding proteins, and ovarian IGF mRNA in sheep with different ovulation rates. J. Anim. Sci. 1995; 73:1152-1163.
Spicer L, Hanrahan J, Zavy M, Enright W. Relationship between ovulation rate and concentrations of insulin-like growth factor-1 in plasma during the estrous cycle in various genotypes of sheep. J. Rep. Fert. 1993; 97:403-409.
Spicer L, Santiago C, Davidson T, Bridges T, Chamberlain C. Follicular fluid concentrations of free insulin-like growth factor (IGF)-I during follicular development in mares. Dom. Anim. Endoc. 2005; 29:573-581.
Stevenson K, Whates D. Insulin-lije growth factors and their binding proteins in the ovine oviduct during the oestrous cycle. J. Rep. Fert. 1996; 108:31-40.
Woad K, Baxter G, Hogg C, Bramley T, Webb R, Armstrong D. Expression of mRNA encoding insulin-like growth factors I and II and the type 1 IGF receptor in the bovine corpus luteum at defined stages of the estrous cycle. J. Rep. Fert. 2000; 120:293-302.
Xia Y, Weiss J, Polack S, Diedrich K, Ortmann O. Experimental sutdy: Intercations of insulin-like growth factor-I, insulin and estradiol with GnRH-stimulated luteinizing hormone release from female rat gonadotrophs. Europ. J. Endoc. 2001;144:73-79.
Zulu V, Nakada K, Sawamukai Y. Insulin-like growth factor-I as a possible hormonal mediator of nutritional regulation in reproduction in cattle. J. Vet. Med. Sci. 2002; 64:657-665.
Zulu V, Sawamukai Y, Nakada K, Kida K, Moriyoshi M. Relationship among insulin-like growth factor-I, blood metabolities and postpartum ovarian function in dairy cows. J. Vet. Med. Sci. 2002; 64:879-885.
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