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Publication Date: 2007-12-21
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López Zapata, D. F. (2007). New findings in four undervalued cells of the Immune system. Biosalud, 6, 131–147. Retrieved from https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/5850
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Abstract
The knowledge about cells associated with the innate immunity has had an incredible transformation in the last years; they have changed from simple effectors to true regulators of the immune response. Within their current functions, the neutrophils control antigen presentation, the probable lymphocyte stimulation ability, the synthesis of different cytokines with the capacity to alter the immune response, and the ability to return to circulation after participating in the tissue inflammatory process. The eosinophil function in the allergic phenomena is currently clearer than in past years. Likewise, the eosinophils have the antigen presentation and T lymphocyte stimulation ability, as well as the eosinophil generation from bone marrow precursors is nowadays better understood. On the other hand, mast cells and basophils, cells previously related one to the other, have a clearer formation process, their individual functions are everyday better documented, and include defense against parasitic, bacterial, viral diseases to their function in allergies. The study of these cells with apparently simple functions has greatly revolutionized the knowledge on the immune system.
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References
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Ellis T, Beaman B. Interferon-γ activation of polymorphonuclear neutrophil function. Immunology 2004; 112:2-12.
Theilgaard K, Porse B, Borregaard N. Systems biology of neutrophil differentiation and immune response. Curr Opin Immunol 2006; 18:54-60.
Ludwig I, Geijtenbeek B, Van Kooyk I. Two way communication between neutrophils and dendritic cells. Curr Opin Pharmacol 2006; 6:408-13.
Urban C, Lourido S, Zychlinsky A. How do microbes evade neutrophil killing? Cell Microbiol 2006; 8:1696-97.
Fialkow L, Wang Y, Downey G. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med. 2007; 42:153-64.
Winterbourn C, Hampton M, Livesey J, Kettle A. Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome. J Biol Chem 2006; 281:39860-869.
Buckley C, Ross E, McGettrick H, Osborne C, Haworth O, Schmutz C, et al. Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration. J Leukocyte Biol. 2006; 79:303-11.
Peng S. Neutrophil apoptosis in autoimmunity. J Mol Med. 2006; 84:122-25.
Ferrari D, La Sala A, Panther E, Norgauer J, Di Virgilio F, Idzko M. Activation of human eosinophils via P2 receptors: novel findings and future perspectives. J Leukocyte Biol. 2006; 79:7-15.
Mcnagny K, Graf T. Making eosinophils through subtle shifts in transcription factor expression. J. Exp. Med. 2002; 195:F43-F47.
Prussin C, Metcalfe D. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 2005; 117:S450-S456.
Shi H. Eosinophils function as antigen-presenting cells. J Leukocyte Biol. 2004; 76:520-27.
Bandeira C, Weller P. Mechanisms of eosinophil cytokine release. Mem. Inst. Oswaldo Cruz 2005; 100:73-81.
Kato M, Kita H, Tachibana A, Hayashi Y, Tsuchida Y, Kimura H. Dual signaling and effector pathways mediate human eosinophil activation by platelet-activating-factor. Intl Arch Allergy Immunol. 2004; 134:37-43.
Yamaguchi T, Suzuki M, Kimura H, Kato M. Role of protein kinase C in eosinophil function. Allergol Int. 2006; 55:245-52.
Wang J, Slungaard A. Role of eosinophil peroxidase in host defense and disease pathology. Arch Biochem Biophy 2006; 445:256-60.
Paoliello A, Oliveira S, Cunha F. Interleukin 4 induces the expression of inducible nitric oxide synthase in eosinophils. Cytokine 2005; 30:116-24.
Morgan D, Cherny V, Murphy R, Katz B, Decoursey T. The pH dependence of NADPH oxidase in uman eosinophils. J Physiol. 2005; 569:419-31.
Levy R. The role of cytosolic phospholipase A2-alfa in regulation of phagocytic functions. Biochim Biophys Acta 2006; 1761:1323-34.
Odemuyiwa S, Ghahary A, Li Y, Puttagunta L, Lee J, Musat S, et al. Cutting edge: human eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenase. J Immunol. 2004; 173:5909-13.
Adamko D, Odemuyiwa S, Vethanayagam D, Moqbel R. The rise of the phoenix: the expanding role of the eosinophil in health and disease. Allergy 2005; 60:13-22.
Puxeddu I, Ribatti D, Crivellato E, Levi F. Mast cells and eosinophils: a novel link between inflammation and angiogenesis in allergic diseases. J Allergy Clin Immunol. 2005; 116:531-36.
Shakoory B, Fitzgerald S, Lee S, Chi D, Krishnaswamy G. The role of human mast cell-derived cytokines in eosinophil biology. J Interferon Cytokine Res 2004; 24:271-81.
Kay A. The role of eosinophils in the pathogenesis of asthma. Trends Mol Med. 2005; 11:148-52.
Yu M, Tsai M, Tam S, Jones C, Zehnder J, Galli S. Mast cells can promote the development of multiple features of chronic asthma in mice. J. Clin. Invest. 2006; 116:1633-41.
Dawicki W, Marshall J. New and emerging roles for mast cells in host defence. Curr Opin Immunol. 2007; 19:31-38.
Okayama Y, Kawakami T. Development, migration, and survival of mast cells. Immunol Res. 2006; 34:97-115.
Kitamura Y, Ito A. Mast cell-committed progenitors. Proc. Natl. Acad. Sci. USA. 2005; 102:11129-130.
Gurish M, Boyce A. Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell. J Allergy Clin. Immunol. 2006; 117:1285-91.
Henz B, Maurer M, Lippert U, Worm M, Babina M. Mast cells as initiators of immunity and host defense. Exp Dermatol. 2001; 10:1-10.
Galli S, Nakae S, Tsai M. Mast cells in the development of adaptive immune responses. Nat Immunol. 2005; 6:135-42.
Féger F, Varadaradjalou S, Gao Z, Abraham S, Arock M. The role of mast cells in host defense and their subversion by bacterial pathogens. Trends Immunol. 2002; 23:151-58.
Theoharides T, Conti P. Mast cells: the JEKILL and HIDE of tumor growth. Trends Immunol. 2004; 25:235-41.
Barrett K. Mechanisms for amplified mediators release from colonic mast cells: implications for intestinal inflammatory diseases. World J Gastroenterol 2004; 10:617-19.
Kawakami T, Kitaura J. Mast cell survival and activatition by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance. J Immunol. 2005; 175:4167-73.
Yannay N, Razin E. Translation and transcription: the dual functionality of LysRS in mast cells. Mol Cells 2006; 22:127-32.
Li L, Yao Z. Mast cell and inhibitory receptors. Cell Mol Immunol. 2004; 1:408-15.
Poncet P, Arock M, David B. MHC class II-dependent activation of CD4+ T cell hybridomas by human mast cells through superantigen presentation. J Leukocyte Biol. 1999; 66:105-12.
Baram D, Peng Z, Medalia O, Mekori Y, Sagi R. Synaptotagmin II negatively regulates MHC class II presentation by mast cells. Mol Immunol. 2001; 38:1347-52.
Stelekati E, Orinska Z, Bulfone S. Mast cells in allergy: Innate instructors of adaptive responses. Immunobiol. 2007; 212:505-19.
Metz M, Maurer M. Mast cells―key effector cells in immune responses. Trends Immunol. 2007; 28:234-41.
Rodella L, Rezzani R, Buffoli B, Bonomini F, Tengattini S, Laffranchi L, et al. Role of mast cells in wound healing process after glass-fiber composite implant in rats. J. Cell. Mol. Med. 2006; 10:946-54.
Özdemir Ö. Immunosurveillance function of human mast cells? World J Gastroenterol 2005; 11:7054-56.
Ch’ng S, Wallis R, Yuan L, Davis P, Tan S. Mast cells and cutaneous malignancies. Mod. Pathol. 2006; 19:149-59.
Ito A, Oonuma J. Direct interaction between nerves and mast cells mediated by the SgIGSF/SynCAM adhesion molecule. J Pharmacol Sci. 2006; 102:1-5.
Triggiani M, Marone G. Basophil’s secrets revealed by flow cytometry. Allergy 2006; 61:1025-27.
Falcone F, Zillikens D, Gibbs B. The 21st century renaissance of the basophil? Current insights into its role in allergic responses and innate immunity. Exp Dermatol. 2006; 15:855-64.
Gibbs B. Human basophils as effectors and immunomodulators of allergic inflammation and innate immunity. Clin. Exp. Med. 2005; 5:43-49.
Arock M, Schneider E, Boissan M, Tricottet V, Dy M. Differentiation of human basophils: an overview of recent advances and pending questions. J Leukocyte Biol. 2002; 71:557-64.
Min B, Le Gros G, Paul W. Basophils: a potential liaison between innate and adaptive immunity. Allergol Int. 2006; 55:99-104.
Yoshimoto T, Nakanishi K. Roles of IL-18 in basophils and mast cells. Allergol Int. 2006; 55:105-13.
Dvorak A. Ultrastructural studies of human basophils and mast cells. J Histochem Cytochem 2005; 53:1043-70.
Falcone F, Pritchard D, Gibbs B. Do basophils play a role in immunity against parasites? Trends Parasitol. 2001; 17:126-29.
Shreffler W. Evaluation of basophil activation in food allergy: present and future applications. Curr. Opin Allergy Clin. Immunol. 2006; 6:226-33.
Oehler L, Majdic O, Pickl W, Stöckl J, Riedl E, Drach J, et al. Neutrophil granulocyte–committed cells can be driven to acquire dendritic cell Characteristics. J. Exp. Med. 1998; 187:1019–28.
Ellis T, Beaman B. Interferon-γ activation of polymorphonuclear neutrophil function. Immunology 2004; 112:2-12.
Theilgaard K, Porse B, Borregaard N. Systems biology of neutrophil differentiation and immune response. Curr Opin Immunol 2006; 18:54-60.
Ludwig I, Geijtenbeek B, Van Kooyk I. Two way communication between neutrophils and dendritic cells. Curr Opin Pharmacol 2006; 6:408-13.
Urban C, Lourido S, Zychlinsky A. How do microbes evade neutrophil killing? Cell Microbiol 2006; 8:1696-97.
Fialkow L, Wang Y, Downey G. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med. 2007; 42:153-64.
Winterbourn C, Hampton M, Livesey J, Kettle A. Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome. J Biol Chem 2006; 281:39860-869.
Buckley C, Ross E, McGettrick H, Osborne C, Haworth O, Schmutz C, et al. Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration. J Leukocyte Biol. 2006; 79:303-11.
Peng S. Neutrophil apoptosis in autoimmunity. J Mol Med. 2006; 84:122-25.
Ferrari D, La Sala A, Panther E, Norgauer J, Di Virgilio F, Idzko M. Activation of human eosinophils via P2 receptors: novel findings and future perspectives. J Leukocyte Biol. 2006; 79:7-15.
Mcnagny K, Graf T. Making eosinophils through subtle shifts in transcription factor expression. J. Exp. Med. 2002; 195:F43-F47.
Prussin C, Metcalfe D. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 2005; 117:S450-S456.
Shi H. Eosinophils function as antigen-presenting cells. J Leukocyte Biol. 2004; 76:520-27.
Bandeira C, Weller P. Mechanisms of eosinophil cytokine release. Mem. Inst. Oswaldo Cruz 2005; 100:73-81.
Kato M, Kita H, Tachibana A, Hayashi Y, Tsuchida Y, Kimura H. Dual signaling and effector pathways mediate human eosinophil activation by platelet-activating-factor. Intl Arch Allergy Immunol. 2004; 134:37-43.
Yamaguchi T, Suzuki M, Kimura H, Kato M. Role of protein kinase C in eosinophil function. Allergol Int. 2006; 55:245-52.
Wang J, Slungaard A. Role of eosinophil peroxidase in host defense and disease pathology. Arch Biochem Biophy 2006; 445:256-60.
Paoliello A, Oliveira S, Cunha F. Interleukin 4 induces the expression of inducible nitric oxide synthase in eosinophils. Cytokine 2005; 30:116-24.
Morgan D, Cherny V, Murphy R, Katz B, Decoursey T. The pH dependence of NADPH oxidase in uman eosinophils. J Physiol. 2005; 569:419-31.
Levy R. The role of cytosolic phospholipase A2-alfa in regulation of phagocytic functions. Biochim Biophys Acta 2006; 1761:1323-34.
Odemuyiwa S, Ghahary A, Li Y, Puttagunta L, Lee J, Musat S, et al. Cutting edge: human eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenase. J Immunol. 2004; 173:5909-13.
Adamko D, Odemuyiwa S, Vethanayagam D, Moqbel R. The rise of the phoenix: the expanding role of the eosinophil in health and disease. Allergy 2005; 60:13-22.
Puxeddu I, Ribatti D, Crivellato E, Levi F. Mast cells and eosinophils: a novel link between inflammation and angiogenesis in allergic diseases. J Allergy Clin Immunol. 2005; 116:531-36.
Shakoory B, Fitzgerald S, Lee S, Chi D, Krishnaswamy G. The role of human mast cell-derived cytokines in eosinophil biology. J Interferon Cytokine Res 2004; 24:271-81.
Kay A. The role of eosinophils in the pathogenesis of asthma. Trends Mol Med. 2005; 11:148-52.
Yu M, Tsai M, Tam S, Jones C, Zehnder J, Galli S. Mast cells can promote the development of multiple features of chronic asthma in mice. J. Clin. Invest. 2006; 116:1633-41.
Dawicki W, Marshall J. New and emerging roles for mast cells in host defence. Curr Opin Immunol. 2007; 19:31-38.
Okayama Y, Kawakami T. Development, migration, and survival of mast cells. Immunol Res. 2006; 34:97-115.
Kitamura Y, Ito A. Mast cell-committed progenitors. Proc. Natl. Acad. Sci. USA. 2005; 102:11129-130.
Gurish M, Boyce A. Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell. J Allergy Clin. Immunol. 2006; 117:1285-91.
Henz B, Maurer M, Lippert U, Worm M, Babina M. Mast cells as initiators of immunity and host defense. Exp Dermatol. 2001; 10:1-10.
Galli S, Nakae S, Tsai M. Mast cells in the development of adaptive immune responses. Nat Immunol. 2005; 6:135-42.
Féger F, Varadaradjalou S, Gao Z, Abraham S, Arock M. The role of mast cells in host defense and their subversion by bacterial pathogens. Trends Immunol. 2002; 23:151-58.
Theoharides T, Conti P. Mast cells: the JEKILL and HIDE of tumor growth. Trends Immunol. 2004; 25:235-41.
Barrett K. Mechanisms for amplified mediators release from colonic mast cells: implications for intestinal inflammatory diseases. World J Gastroenterol 2004; 10:617-19.
Kawakami T, Kitaura J. Mast cell survival and activatition by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance. J Immunol. 2005; 175:4167-73.
Yannay N, Razin E. Translation and transcription: the dual functionality of LysRS in mast cells. Mol Cells 2006; 22:127-32.
Li L, Yao Z. Mast cell and inhibitory receptors. Cell Mol Immunol. 2004; 1:408-15.
Poncet P, Arock M, David B. MHC class II-dependent activation of CD4+ T cell hybridomas by human mast cells through superantigen presentation. J Leukocyte Biol. 1999; 66:105-12.
Baram D, Peng Z, Medalia O, Mekori Y, Sagi R. Synaptotagmin II negatively regulates MHC class II presentation by mast cells. Mol Immunol. 2001; 38:1347-52.
Stelekati E, Orinska Z, Bulfone S. Mast cells in allergy: Innate instructors of adaptive responses. Immunobiol. 2007; 212:505-19.
Metz M, Maurer M. Mast cells―key effector cells in immune responses. Trends Immunol. 2007; 28:234-41.
Rodella L, Rezzani R, Buffoli B, Bonomini F, Tengattini S, Laffranchi L, et al. Role of mast cells in wound healing process after glass-fiber composite implant in rats. J. Cell. Mol. Med. 2006; 10:946-54.
Özdemir Ö. Immunosurveillance function of human mast cells? World J Gastroenterol 2005; 11:7054-56.
Ch’ng S, Wallis R, Yuan L, Davis P, Tan S. Mast cells and cutaneous malignancies. Mod. Pathol. 2006; 19:149-59.
Ito A, Oonuma J. Direct interaction between nerves and mast cells mediated by the SgIGSF/SynCAM adhesion molecule. J Pharmacol Sci. 2006; 102:1-5.
Triggiani M, Marone G. Basophil’s secrets revealed by flow cytometry. Allergy 2006; 61:1025-27.
Falcone F, Zillikens D, Gibbs B. The 21st century renaissance of the basophil? Current insights into its role in allergic responses and innate immunity. Exp Dermatol. 2006; 15:855-64.
Gibbs B. Human basophils as effectors and immunomodulators of allergic inflammation and innate immunity. Clin. Exp. Med. 2005; 5:43-49.
Arock M, Schneider E, Boissan M, Tricottet V, Dy M. Differentiation of human basophils: an overview of recent advances and pending questions. J Leukocyte Biol. 2002; 71:557-64.
Min B, Le Gros G, Paul W. Basophils: a potential liaison between innate and adaptive immunity. Allergol Int. 2006; 55:99-104.
Yoshimoto T, Nakanishi K. Roles of IL-18 in basophils and mast cells. Allergol Int. 2006; 55:105-13.
Dvorak A. Ultrastructural studies of human basophils and mast cells. J Histochem Cytochem 2005; 53:1043-70.
Falcone F, Pritchard D, Gibbs B. Do basophils play a role in immunity against parasites? Trends Parasitol. 2001; 17:126-29.
Shreffler W. Evaluation of basophil activation in food allergy: present and future applications. Curr. Opin Allergy Clin. Immunol. 2006; 6:226-33.
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