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Publication Date: 2013-06-21
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Jaramillo Rodríguez, O. D., & González Correa, C. H. (2013). Probiotics in primary prevention of atopic dermatitis in infants at risk of suffering it. Metaanalysis. Biosalud, 12(1), 18–28. Retrieved from https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/4703
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Abstract
Background: Several studies have used different protocols to evaluate the effect of probiotics in patients at high risk of suffering atopic dermatitis, producing conflicting results. A meta-analysis of randomized double-blind clinical trials was conducted was to elucidate the effect of its use during pregnancy. Methods: The literature search included the PubMed, ScienceDirect, Proquest, and Ovid databases. The keywords were probiotics ATOPIC DERMATITIS and atopic dermatitis. PROBIOTICS. The outcome variable was the incidence of atopic dermatitis. The Cho and Bero scale was used to assess the methodological quality of the articles. For statistical analysis the RevMan 5.1 software and the Mantel-Haenszel test using fixed and ramdomized models were used. Calculations were performed by using the fixed and random effects models. Heterogeneity was examined using the X² test and publication bias was assessed by using the funnel plot and the Egger's statistical test. Results: Seven studies including 1,237 children were analyzed. It was found that the use of probiotics during pregnancy reduces the risk of atopic dermatitis in infants with an odds ratio of 0.64 and confidence intervals of 95% from 0.5 to 0.82.
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References
Shekariah T, Kalavala M, Alfaham M. Atopic dermatitis in children: a practical approach. Paediatr Child Health. 2011; 21(3):112-118.
Schultz Larsen F, Hanifin JM. Secular change in the occurrence of atopic dermatitis. Acta Derm Venereol Suppl. 1992; 176:7-12.
Hong S, Son DK, Lim WR, Kim SH, Kim H, Yum HY, Kwon H. The prevalence of atopic dermatitis, asthma, and allergic rhinitis and the comorbidity of allergic diseases in children. Environ Health Toxicol. 2012; 27:13.
Olmos C, Ramon K. Dermatitis Atópica ¿Qué hay de nuevo? PRECOP SCP. 2010; 9(1):16-24.
Lau S, Nickel R, Niggemann B, Gruber C, Sommerfeld C, Illi S, Kulig M, Forster J, Wahn U, Groeger M, Zepp F, Kamin W, Bieber I, Tacke U, Wahn V, Bauer CP, Bergmann R, Von Mutius E. The development of childhood asthma: lessons from the German Multicentre Allergy Study (MAS). Paediatr Respir Rev. 2002; 3(3):265-272.
Gustafsson D, Sjoberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis--a prospective follow-up to 7 years of age. Allergy. 2000; 55(3):240-245.
Spergel JM. Epidemiology of atopic dermatitis and atopic march in children. Immunol Allergy Clin North Am. 2010; 30(3):269-280.
Ong PY, Boguniewicz M. Atopic Dermatitis. Prim. Care. 2008; 35(1):105-11.
Chan SK, Burrows NP. Atopic Dermatitis. Medicine. 2009; 37(5):242-245.
Cookson WO, Moffatt MF. The genetics of atopic dermatitis. Curr Opin Allergy Clin. Immunol. 2002; 2:383-387.
Cabana MD, McKean M, Wong AR, Chao C, Caughey AB. Examining the hygiene hypothesis: the Trial of Infant Probiotic Supplementation. Paediatr Perinat Epidemiol. 2007; 21(3):23-28.
Wold AE. The hygiene hypothesis revised: is the rising frequency of allergy due to changes in the intestinal flora? Allergy. 1998; 53:20-25.
Kaplan JL, Shi HN, Walker WA. The Role of Microbes in Developmental Immunologic Programming. [Review]. Pediatr Res. 2011; 69(6):465-472.
Penders J, Stobberingh EE, van den Brandt PA, Thij C. The role of the intestinal microbiota in the development of atopic disorders. Allergy. 2007; 62(11):1223-1236.
Borchers AT, Selmi C, Meyers FJ, Keen CL, Gershwin ME. Probiotics and immunity. J Gastroenterol. 2009; 44(1):26-46.
Prescott SL, Bjarkstaon B. Probiotics for the prevention or treatment of allergic diseases. J Allergy Clin Immunol. 2007; 120(2):255-262.
Thum C, Cookson AL, Nutria DE, McNabb WC, Hodgkinson AJ, Dyer J, Roy NC. Can nutritional modulation of maternal intestinal microbiota influence the development of the infant gastrointestinal tract? J Nutr. 2012; 142(11):1921-8.
Lee J, Seto D, Bielory L. Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis. J Allergy ClinImmunol. 2008; 121(1):116-121.e11.
Dotterud CK, Storro O, Johnsen R, Oien T. Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial. Br J Dermatol. 2010; 163(3):616-623.
Wickens K, Black PN, Stanley TV, Mitchell E, Fitzharris P, Tannock GW, Purdie G, Crane J. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebocontrolled trial. J Allergy Clin Immunol. 2008; 122(4):788-794.
Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detect by a simple graphical test. BMJ. 1997; 315:629-634.
Hsieh MH, Versalovic J. The human microbiome and probiotics: implications for pediatrics. Curr Probl Pediatr Adolesc Health Care. 2008; 38(10):309-327.
Chapman CMC, Gibson GR, Rowland I. Health benefits of probiotics: are mixtures more effective than single strains? Eur J Nutr. 2011; 50(1):1-17.
Pelucchi C, Chatenoud L, Turati F, Galeone C, Moja L, Bach JF, La Vecchia C. Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis. Epidemiology. 2012; 23(3):402-414.
Huurre A, Laitinen K, Rautava S, Korkeamaki M, Isolauri E. Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study. Clin Exp Allergy. 2008; 38(8):1342-1348.
Prescott SL, Wickens K, Westcott L, Jung W, Currie H, Black PN, Stanley TV, Mitchell EA, Fitzharris P, Siebers R, Wu L, Crane J. Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection. Clin Exp Allergy. 2008; 38(10):1606-1614.
Doege K, Grajecki D, Zyriax BC, Detinkina E, Zu Eulenburg C, Buhling KJ. Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood - a meta-analysis. Br J Nutr. 2012; 107(1):1-6.
Ozdemir O. Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data. Clin Exp Immunol. 2010; 160(3):295-304.
Kopp MV, Hennemuth I, Heinzmann A, Urbanek R. Randomized, double-blind, placebo-controlled trial of probiotics for primary prevention: no clinical effects of Lactobacillus GG supplementation. Pediatrics. 2008; 121(4):850-856.
Kalliomäki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomized placebo-controlled trial. Lancet. 2001; 357(9262):1076-1079.
Niers L, Martin R, Rijkers G, Sengers F, Timmerman H, van Uden N, Smidt H, Kimpen J, Hoekstra M. The effects of selected probiotic strains on the development of eczema (the Panda study). Allergy. 2009; 64(9):1349-1358.
Kim JY, Kwon JH, Ahn SH, Lee SI, Han YS, Choi YO, Lee SY, Ahn KM, Ji GE. Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial. Pediatr Allergy Immunol. 2009; 21(2):386-e393.
Boyle RJ, Ismail IH, Kivivuori S, Licciardi PV, Robins-Browne RM, Mah LJ, Axelrad C, Moore S, Donath S, Carlin JB, Lahtinen SJ, Tang ML. Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trial. Allergy. 2011; 66(4):509-516.
Schultz Larsen F, Hanifin JM. Secular change in the occurrence of atopic dermatitis. Acta Derm Venereol Suppl. 1992; 176:7-12.
Hong S, Son DK, Lim WR, Kim SH, Kim H, Yum HY, Kwon H. The prevalence of atopic dermatitis, asthma, and allergic rhinitis and the comorbidity of allergic diseases in children. Environ Health Toxicol. 2012; 27:13.
Olmos C, Ramon K. Dermatitis Atópica ¿Qué hay de nuevo? PRECOP SCP. 2010; 9(1):16-24.
Lau S, Nickel R, Niggemann B, Gruber C, Sommerfeld C, Illi S, Kulig M, Forster J, Wahn U, Groeger M, Zepp F, Kamin W, Bieber I, Tacke U, Wahn V, Bauer CP, Bergmann R, Von Mutius E. The development of childhood asthma: lessons from the German Multicentre Allergy Study (MAS). Paediatr Respir Rev. 2002; 3(3):265-272.
Gustafsson D, Sjoberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis--a prospective follow-up to 7 years of age. Allergy. 2000; 55(3):240-245.
Spergel JM. Epidemiology of atopic dermatitis and atopic march in children. Immunol Allergy Clin North Am. 2010; 30(3):269-280.
Ong PY, Boguniewicz M. Atopic Dermatitis. Prim. Care. 2008; 35(1):105-11.
Chan SK, Burrows NP. Atopic Dermatitis. Medicine. 2009; 37(5):242-245.
Cookson WO, Moffatt MF. The genetics of atopic dermatitis. Curr Opin Allergy Clin. Immunol. 2002; 2:383-387.
Cabana MD, McKean M, Wong AR, Chao C, Caughey AB. Examining the hygiene hypothesis: the Trial of Infant Probiotic Supplementation. Paediatr Perinat Epidemiol. 2007; 21(3):23-28.
Wold AE. The hygiene hypothesis revised: is the rising frequency of allergy due to changes in the intestinal flora? Allergy. 1998; 53:20-25.
Kaplan JL, Shi HN, Walker WA. The Role of Microbes in Developmental Immunologic Programming. [Review]. Pediatr Res. 2011; 69(6):465-472.
Penders J, Stobberingh EE, van den Brandt PA, Thij C. The role of the intestinal microbiota in the development of atopic disorders. Allergy. 2007; 62(11):1223-1236.
Borchers AT, Selmi C, Meyers FJ, Keen CL, Gershwin ME. Probiotics and immunity. J Gastroenterol. 2009; 44(1):26-46.
Prescott SL, Bjarkstaon B. Probiotics for the prevention or treatment of allergic diseases. J Allergy Clin Immunol. 2007; 120(2):255-262.
Thum C, Cookson AL, Nutria DE, McNabb WC, Hodgkinson AJ, Dyer J, Roy NC. Can nutritional modulation of maternal intestinal microbiota influence the development of the infant gastrointestinal tract? J Nutr. 2012; 142(11):1921-8.
Lee J, Seto D, Bielory L. Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis. J Allergy ClinImmunol. 2008; 121(1):116-121.e11.
Dotterud CK, Storro O, Johnsen R, Oien T. Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial. Br J Dermatol. 2010; 163(3):616-623.
Wickens K, Black PN, Stanley TV, Mitchell E, Fitzharris P, Tannock GW, Purdie G, Crane J. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebocontrolled trial. J Allergy Clin Immunol. 2008; 122(4):788-794.
Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detect by a simple graphical test. BMJ. 1997; 315:629-634.
Hsieh MH, Versalovic J. The human microbiome and probiotics: implications for pediatrics. Curr Probl Pediatr Adolesc Health Care. 2008; 38(10):309-327.
Chapman CMC, Gibson GR, Rowland I. Health benefits of probiotics: are mixtures more effective than single strains? Eur J Nutr. 2011; 50(1):1-17.
Pelucchi C, Chatenoud L, Turati F, Galeone C, Moja L, Bach JF, La Vecchia C. Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis. Epidemiology. 2012; 23(3):402-414.
Huurre A, Laitinen K, Rautava S, Korkeamaki M, Isolauri E. Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study. Clin Exp Allergy. 2008; 38(8):1342-1348.
Prescott SL, Wickens K, Westcott L, Jung W, Currie H, Black PN, Stanley TV, Mitchell EA, Fitzharris P, Siebers R, Wu L, Crane J. Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection. Clin Exp Allergy. 2008; 38(10):1606-1614.
Doege K, Grajecki D, Zyriax BC, Detinkina E, Zu Eulenburg C, Buhling KJ. Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood - a meta-analysis. Br J Nutr. 2012; 107(1):1-6.
Ozdemir O. Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data. Clin Exp Immunol. 2010; 160(3):295-304.
Kopp MV, Hennemuth I, Heinzmann A, Urbanek R. Randomized, double-blind, placebo-controlled trial of probiotics for primary prevention: no clinical effects of Lactobacillus GG supplementation. Pediatrics. 2008; 121(4):850-856.
Kalliomäki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomized placebo-controlled trial. Lancet. 2001; 357(9262):1076-1079.
Niers L, Martin R, Rijkers G, Sengers F, Timmerman H, van Uden N, Smidt H, Kimpen J, Hoekstra M. The effects of selected probiotic strains on the development of eczema (the Panda study). Allergy. 2009; 64(9):1349-1358.
Kim JY, Kwon JH, Ahn SH, Lee SI, Han YS, Choi YO, Lee SY, Ahn KM, Ji GE. Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial. Pediatr Allergy Immunol. 2009; 21(2):386-e393.
Boyle RJ, Ismail IH, Kivivuori S, Licciardi PV, Robins-Browne RM, Mah LJ, Axelrad C, Moore S, Donath S, Carlin JB, Lahtinen SJ, Tang ML. Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trial. Allergy. 2011; 66(4):509-516.
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