Authors
Abstract
Gastric cancer (GC) is one of the major causes of death in the Colombian population. Its incidence is variable and high risk zones have been identified, among them the department of Caldas, and especially Manizales. In this pathology of complex etiology external and internal factors are found. Among the external factors are the occupational and/or environmental exhibitions to carcinogenic or procarcinogens compounds. One of them is cigarette smoke, and therefore its possible association with GC risk was explored. The new cases of GC that arose in 18 months in the Hospital de Caldas were studied. From these, 65 met the inclusion criteria and were matched with 65 controls. The information was collected emphasizing the smoking activity. Significant association was demonstrated between the smoking habit and the risk to GC (OR=2,1, p=0,035). Also significant association was found between GC and the middle and low socioeconomic stratum (p=0,000). In conclusion, these results suggest that quitting smoking is a protector factor to the risk of developing GC; although there are other endogenous and exogenous risk factors that impact the presence of this type of cancer that were not explored in this study.
Keywords:
References
Jemal, A; Thomas, A; Murray, T; Thun, M. Cancer statistics, 2002. CA Cancer J Clin. 2006. 52: 23-47.
Murillo, M.R.; Piñeros, P.M.; Hernández, S.G. Atlas de Mortalidad por Cáncer en Colombia 2003, Imprenta Nacional de Colombia. 2003.
Torres, M.M.; Acosta, C.P.; Sicard, D.M.; Groot, de Restrepo H. Genetic susceptibility and risk of gastric cancer in a human population of Cauca, Colombia. Biomédica. 2004. 24: 153-62.
Lindblad, M; Rodríguez L.A.; Lagergren, J. Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study. Cancer Causes Control. 2005. 3: 285-94.
Setiawan, V.W.; Zhang, Z,F.; Yu, G.P.; Li, Y.L.; Lu, M.L.; Tsai, C.J.; et al. GSTT1 and GSTM1 Null Genotypes and the risk of gastric cancer: a case-control study in a Chinese population. Cancer Epidemiol Biomarkers Prev. 2000. 9: 73-80.
Ye, W; Ekstrom, A.M.; Hansson, L.E.; Bergstrom, R; Nyren, O. Tobacco, alcohol and the risk of gastric cancer by sub-site and histologic type. Int J. Cancer. 1999. 83: 223-229.
Plummer, M; Franceschi, S; Muñoz, N. Epidemiolgy of gastric cancer. IARC Sci Publ. 2004. 157: 311-326.
Peláez, A; Ramírez, J.G.; Ruíz, A. Características y prevalencia de neoplasias malignas del tracto gastrointestinal en el departamento de Antioquia, Segundo semestre de 1996. CES MEDICINA. 1998. 12: 37-43.
Newton, J.L. Changes in upper gastrointestinal physiology with age. Mech Ageing Dev. 2004. 125: 867-870.
Suzuki, K; Suzuki, I; Leodolter, A; Alonso, S; Horiuchi, S; Yamashita, K; et al. Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage. Cancer Cell. 2006. 9: 199-207.
Marchand, L.L.; Wilkinson, G.R.; Wilkens, L.R. Genetic and dietary predictors of CYP2E1 activity: a phenoyping study in Hawaii Japanese using chlorzoxazone. Cancer Epidemiol Biomarkers Prev. 1999. 8: 495-500.
Kim, H.S; Kwack, S.J.; Lee, B.M. Alteration of cytochrome p-450 and glutathione s-transferase activity in normal and malignant human stomach. Journal of toxicology and environmental health, part a. 2005. 68: 1611-1620.
Maguire, A; Porta, M; Sanz-Anquela, J.M.; Ruano, I; Malats, N; Piñol, J.L. Sex as a pronostic factor in gastric cancer. European Journal of Cancer. 1996. 32A: 1303-1309.
Tredaniel, J; Boffetta, P; Buiatti, E; Saracci, R; Hirsch, A. Tobacco smoking and gastric cancer: review and meta analysis. Int J Cancer. 1997. 72: 565-573.
Katoh, T; Nagata, N; Kuroda, Y; Itoh, H; Kawahara, A; Kuroki, N; et al. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. Carcinogenesis. 1996. 17: 1855-1859.
Shin, V.Y.; Cho, C.H. Nicotine and gastric cancer. Alcohol. 2005. 35: 259-64.
González, C.A.; Pera, G; Agudo, A; Palli, D; Krogh, V; Vineis, P; et al. Smoking and the risk of gastric cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Int J Cancer. 2003. 107: 629-634.
Correa, P. A human model of gastric carcinogenesis. Cancer Res. 1988. 48: 3554-60.
Mirvish, S.S. Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Lett. 1995. 93: 17-48.
Schoket, B; Phillips, D.H.; Kostic, S; Vincze, I. Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients. Carcinogenesis. 1998. 19: 841-846.
Iwata, F; Zhang, X.Y.; Leung, F.W. Aggravation of gastric mucosal lesions in rat stomach by tobacco cigarette smoke. Digest Dis Sci. 1995. 40: 1118-1124.
Shin, V.Y.; Wang, H.Y.; Liu, E.S.; Koo, M.N.; Cho, C.H. Differential effects of cigarette smoke extracts on cell proliferation in gastric and colon cells. Cancer Invest. 2003. 2: 200-207.
Salama, S.A.; Abdel-Rahman, S.Z.; Sierra-Torres, C.H.; Hamada, F.A.; Au, W.W. Role of polymorphic GSTM1 and GSTT1 genotypes on NNK-induced genotoxicity. Pharmacogenetics. 1999. 9: 735-43.
Kneller, R.W.; You, W.C.; Chang, Y.S.; Liu, W.D.; Zhang, L; Zhao, L; et al. Cigarette smoking and other risk factors for progression of precancerous stomach lesions. J Nat Cancer Inst. 1992. 84: 1261-1266.