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##plugins.gregg.article.details.published##: 2007-01-01
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Castaño Molina E, Parra Sánchez H. Deixar de fumar: fator protetor de câncer gástrico. Hacia Promoc. Salud [Internet]. 1º de janeiro de 2007 [citado 21º de novembro de 2024];12:125-32. Disponível em: https://revistasojs.ucaldas.edu.co/index.php/hacialapromociondelasalud/article/view/1952
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Resumo
O câncer gástrico é uma das maiores causas da morte na povoaçâo colombiana. Sua incidência é variável e tem identificado zonas de alto risco, entre elas o estado de Caldas e em especial Manizales. Em está patologia de etimologia complexa encontram-se comprometidos fatores externos e internos. Entre os externos estâo as exposições ocupacionais e/ou ambientais a compostos carcinogênicos ou procarcinogenos. Uno de eles é o fumo do charuto e por esta razâo exploro-se a sua possível associaçâo com o risco a CG. Estudaram se os casos novos de CG que presentearam se durante 18 mêses no hospital de Caldas. De eles, 65 reuniram os critérios de inclusâo e emparelhou-se com 65 controles. Coleto-se a informaçâo fazendo ênfase em tabagismo. Evidencia-se a associaçâo significativa entre o hábito de fumar e o risco a CG (OR=2,1,0.035). Também encontrarem-se uma associaçâo significativa entre o CG e os estratos socioeconômicos médios baixos (p=0.000). Em conclusâo, estes resultados sugerem que deixar de fumar protege do risco a desenvolver CG; porém também existem outros fatores de risco endógeno e exógeno que incidem na apresentaçâo deste tipo de câncer que no foram explorados neste estúdio.
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Referências
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Iwata, F; Zhang, X.Y.; Leung, F.W. Aggravation of gastric mucosal lesions in rat stomach by tobacco cigarette smoke. Digest Dis Sci. 1995. 40: 1118-1124.
Shin, V.Y.; Wang, H.Y.; Liu, E.S.; Koo, M.N.; Cho, C.H. Differential effects of cigarette smoke extracts on cell proliferation in gastric and colon cells. Cancer Invest. 2003. 2: 200-207.
Salama, S.A.; Abdel-Rahman, S.Z.; Sierra-Torres, C.H.; Hamada, F.A.; Au, W.W. Role of polymorphic GSTM1 and GSTT1 genotypes on NNK-induced genotoxicity. Pharmacogenetics. 1999. 9: 735-43.
Kneller, R.W.; You, W.C.; Chang, Y.S.; Liu, W.D.; Zhang, L; Zhao, L; et al. Cigarette smoking and other risk factors for progression of precancerous stomach lesions. J Nat Cancer Inst. 1992. 84: 1261-1266.
Jemal, A; Thomas, A; Murray, T; Thun, M. Cancer statistics, 2002. CA Cancer J Clin. 2006. 52: 23-47.
Murillo, M.R.; Piñeros, P.M.; Hernández, S.G. Atlas de Mortalidad por Cáncer en Colombia 2003, Imprenta Nacional de Colombia. 2003.
Torres, M.M.; Acosta, C.P.; Sicard, D.M.; Groot, de Restrepo H. Genetic susceptibility and risk of gastric cancer in a human population of Cauca, Colombia. Biomédica. 2004. 24: 153-62.
Lindblad, M; Rodríguez L.A.; Lagergren, J. Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study. Cancer Causes Control. 2005. 3: 285-94.
Setiawan, V.W.; Zhang, Z,F.; Yu, G.P.; Li, Y.L.; Lu, M.L.; Tsai, C.J.; et al. GSTT1 and GSTM1 Null Genotypes and the risk of gastric cancer: a case-control study in a Chinese population. Cancer Epidemiol Biomarkers Prev. 2000. 9: 73-80.
Ye, W; Ekstrom, A.M.; Hansson, L.E.; Bergstrom, R; Nyren, O. Tobacco, alcohol and the risk of gastric cancer by sub-site and histologic type. Int J. Cancer. 1999. 83: 223-229.
Plummer, M; Franceschi, S; Muñoz, N. Epidemiolgy of gastric cancer. IARC Sci Publ. 2004. 157: 311-326.
Peláez, A; Ramírez, J.G.; Ruíz, A. Características y prevalencia de neoplasias malignas del tracto gastrointestinal en el departamento de Antioquia, Segundo semestre de 1996. CES MEDICINA. 1998. 12: 37-43.
Newton, J.L. Changes in upper gastrointestinal physiology with age. Mech Ageing Dev. 2004. 125: 867-870.
Suzuki, K; Suzuki, I; Leodolter, A; Alonso, S; Horiuchi, S; Yamashita, K; et al. Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage. Cancer Cell. 2006. 9: 199-207.
Marchand, L.L.; Wilkinson, G.R.; Wilkens, L.R. Genetic and dietary predictors of CYP2E1 activity: a phenoyping study in Hawaii Japanese using chlorzoxazone. Cancer Epidemiol Biomarkers Prev. 1999. 8: 495-500.
Kim, H.S; Kwack, S.J.; Lee, B.M. Alteration of cytochrome p-450 and glutathione s-transferase activity in normal and malignant human stomach. Journal of toxicology and environmental health, part a. 2005. 68: 1611-1620.
Maguire, A; Porta, M; Sanz-Anquela, J.M.; Ruano, I; Malats, N; Piñol, J.L. Sex as a pronostic factor in gastric cancer. European Journal of Cancer. 1996. 32A: 1303-1309.
Tredaniel, J; Boffetta, P; Buiatti, E; Saracci, R; Hirsch, A. Tobacco smoking and gastric cancer: review and meta analysis. Int J Cancer. 1997. 72: 565-573.
Katoh, T; Nagata, N; Kuroda, Y; Itoh, H; Kawahara, A; Kuroki, N; et al. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. Carcinogenesis. 1996. 17: 1855-1859.
Shin, V.Y.; Cho, C.H. Nicotine and gastric cancer. Alcohol. 2005. 35: 259-64.
González, C.A.; Pera, G; Agudo, A; Palli, D; Krogh, V; Vineis, P; et al. Smoking and the risk of gastric cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Int J Cancer. 2003. 107: 629-634.
Correa, P. A human model of gastric carcinogenesis. Cancer Res. 1988. 48: 3554-60.
Mirvish, S.S. Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Lett. 1995. 93: 17-48.
Schoket, B; Phillips, D.H.; Kostic, S; Vincze, I. Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients. Carcinogenesis. 1998. 19: 841-846.
Iwata, F; Zhang, X.Y.; Leung, F.W. Aggravation of gastric mucosal lesions in rat stomach by tobacco cigarette smoke. Digest Dis Sci. 1995. 40: 1118-1124.
Shin, V.Y.; Wang, H.Y.; Liu, E.S.; Koo, M.N.; Cho, C.H. Differential effects of cigarette smoke extracts on cell proliferation in gastric and colon cells. Cancer Invest. 2003. 2: 200-207.
Salama, S.A.; Abdel-Rahman, S.Z.; Sierra-Torres, C.H.; Hamada, F.A.; Au, W.W. Role of polymorphic GSTM1 and GSTT1 genotypes on NNK-induced genotoxicity. Pharmacogenetics. 1999. 9: 735-43.
Kneller, R.W.; You, W.C.; Chang, Y.S.; Liu, W.D.; Zhang, L; Zhao, L; et al. Cigarette smoking and other risk factors for progression of precancerous stomach lesions. J Nat Cancer Inst. 1992. 84: 1261-1266.
