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Fecha Publicación: 2008-12-19
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Osorio, J. H., Aguirre, C. A., & Valencia, M. H. (2008). Implicaciones metabólicas y clínicas del uso de los inhibidores de la 3-hidroxi-3-metilglutaril coenzima a reductasa para el control de la hipercolesterolemia. Biosalud, 7, 115–129. Recuperado a partir de https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/5837
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La hipercolesterolemia es importante como factor de riesgo para enfermedad cardiovascular. El tratamiento con estatinas de la hipercolesterolemia, se basa en la inhibición competitiva de la 3-hidroxi-3-metilglutaril coenzima A reductasa (HMG-CoA), que cataliza un paso limitante de la biosintesis del colesterol. La presente revisión analiza la literatura científica relacionada con el metabolismo del colesterol y las implicaciones clínico-metabólicas del uso de estatinas para el control de colesterol.
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Razani B, Chakravarthy MV, Semenkovich CF.Insulin resistance and atherosclerosis. Endocrinol Metab Clin North Am. 2008;37(3):603-21.
Nicholls SJ. HDL: still a target for new therapies? Curr Opin Investig Drugs. 2008 Sep;9(9):950-6.
Amarenco P. Lipid lowering and recurrent stroke: a definitive answer? Int J Stroke. 2007;2(2):111-3.
Brodsky JL, Fisher EA. The many intersecting pathways underlying apolipoprotein B secretion and degradation. Trends Endocrinol Metab. 2008;19(7):254-9.
Bordoni A, Di Nunzio M, Danesi F, Biagi PL. Polyunsaturated fatty acids: From diet to binding to ppars and other nuclear receptors. Genes Nutr. 2006;1(2):95-106.
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Ailhaud G. Omega-6 fatty acids and excessive adipose tissue development. World Rev Nutr Diet. 2008;98:51-61.
Boden G. Obesity and free fatty acids. Endocrinol Metab Clin North Am. 2008 Sep;37(3):635-46.
Vine DF, Glimm DR, Proctor SD. Intestinal lipid transport and chylomicron production: possible links to exacerbated atherogenesis in a rodent model of the metabolic syndrome. Atheroscler Suppl. 2008;9(2):69-76.
Vourvouhaki E, Dedoussis GV. Cholesterol ester transfer protein: a therapeutic target in atherosclerosis? Expert Opin Ther Targets. 2008;12(8):937-48.
Kratz M. Dietary cholesterol, atherosclerosis and coronary heart disease. Handb Exp Pharmacol. 2005;(170):195-213.
Blain JF, Poirier J. Cholesterol homeostasis and the pathophysiology of Alzheimer’s disease. Expert Rev Neurother. 2004;4(5):823-9.
Mouritsen OG, Zuckermann MJ. What’s so special about cholesterol? Lipids. 2004;39(11):1101-13.
Backes JM, Gibson CA. Effect of lipid-lowering drug therapy on small-dense low-density lipoprotein. Ann Pharmacother. 2005;39(3):523-6.
Brunner EJ, Rees K, Ward K, Burke M, Thorogood M. Dietary advice for reducing cardiovascular risk. Cochrane Database Syst Rev. 2007.
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von Eckardstein A. Risk factors for atherosclerotic vascular disease. Handb Exp Pharmacol. 2005;(170):71-105.
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Amarenco P. Lipid lowering and recurrent stroke: a definitive answer? Int J Stroke. 2007;2(2):111-3.
Brodsky JL, Fisher EA. The many intersecting pathways underlying apolipoprotein B secretion and degradation. Trends Endocrinol Metab. 2008;19(7):254-9.
Bordoni A, Di Nunzio M, Danesi F, Biagi PL. Polyunsaturated fatty acids: From diet to binding to ppars and other nuclear receptors. Genes Nutr. 2006;1(2):95-106.
Barter P, Ginsberg HN. Effectiveness of combined statin plus omega-3 fatty acid therapy for mixed dyslipidemia. Am J Cardiol. 2008;102(8):1040-5.
Ailhaud G. Omega-6 fatty acids and excessive adipose tissue development. World Rev Nutr Diet. 2008;98:51-61.
Boden G. Obesity and free fatty acids. Endocrinol Metab Clin North Am. 2008 Sep;37(3):635-46.
Vine DF, Glimm DR, Proctor SD. Intestinal lipid transport and chylomicron production: possible links to exacerbated atherogenesis in a rodent model of the metabolic syndrome. Atheroscler Suppl. 2008;9(2):69-76.
Vourvouhaki E, Dedoussis GV. Cholesterol ester transfer protein: a therapeutic target in atherosclerosis? Expert Opin Ther Targets. 2008;12(8):937-48.
Kratz M. Dietary cholesterol, atherosclerosis and coronary heart disease. Handb Exp Pharmacol. 2005;(170):195-213.
Blain JF, Poirier J. Cholesterol homeostasis and the pathophysiology of Alzheimer’s disease. Expert Rev Neurother. 2004;4(5):823-9.
Mouritsen OG, Zuckermann MJ. What’s so special about cholesterol? Lipids. 2004;39(11):1101-13.
Backes JM, Gibson CA. Effect of lipid-lowering drug therapy on small-dense low-density lipoprotein. Ann Pharmacother. 2005;39(3):523-6.
Brunner EJ, Rees K, Ward K, Burke M, Thorogood M. Dietary advice for reducing cardiovascular risk. Cochrane Database Syst Rev. 2007.
DeFaria Yeh D, Freeman MW, Meigs JB, Grant RW. Risk factors for coronary artery disease in patients with elevated high-density lipoprotein cholesterol. Am J Cardiol. 2007; 99(1):1-4.
Hachem SB, Mooradian AD. Familial dyslipidaemias: an overview of genetics, pathophysiology and management. Drugs. 2006;66(15):1949-69.
Blank RC, Brunton S. Managing multiple cardiovascular risk factors. J Fam Pract. 2008;57(3 Suppl Managing):S13-20.
Toth PP, Davidson MH. High-dose statin therapy: benefits and safety in aggressive lipid lowering. J Fam Pract. 2008;57(5 Suppl High-Dose):S29-36.
Grigore L, Norata GD, Catapano AL. Combination therapy in cholesterol reduction: focus on ezetimibe and statins. Vasc Health Risk Manag. 2008;4(2):267-78.
Kratz M. Dietary cholesterol, atherosclerosis and coronary heart disease. Handb Exp Pharmacol. 2005;(170):195-213.
Grundy SM. Metabolic syndrome: therapeutic considerations Handb Exp Pharmacol. 2005;(170):107-33.
von Eckardstein A. Risk factors for atherosclerotic vascular disease. Handb Exp Pharmacol. 2005;(170):71-105.
Bocksch W, Fateh-Moghadam S, Huehns S, Schartl M. Influence of different lipid-lowering strategies on plaque volume and plaque composition in patients with coronary artery disease: role of intravascular ultrasound imaging. Kidney Blood Press Res. 2005;28(5-6):290-4.
Steiner G. Lipid lowering in the patients with prediabetes/metabolic syndrome: what is the evidence? Curr Opin Lipidol. 2008;19(6):585-91.
Tomillero A, Moral MA.Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2008;30(7):543-88.
Guymer RH, Dimitrov PN, Varsamidis M, Lim LL, Baird PN, Vingrys AJ, Robman L. Can HMG Co-A reductase inhibitors (“statins”) slow the progression of age-related macular degeneration? The agerelated maculopathy statin study (ARMSS). Clin Interv Aging. 2008;3(3):581-93.
Koh KK, Quon MJ, Waclawiw MA.Are statins effective for simultaneously treating dyslipidemias and hypertension? Atherosclerosis. 2008 ;196(1):1-8.
Szárszoi O, Malý J, Ostádal P, Netuka I, Besík J, Kolár F, Ostádal B. Effect of acute and chronic simvastatin treatment on post-ischemic contractile dysfunction in isolated rat heart. Physiol Res. 2008;57(5):793-6.
Mandell BF.A drug, a concept, and a clinical trial on trial. Cleve Clin J Med. 2008 ;75(7):470.
Petty D, Lloyd D. Can cheap generic statins achieve national cholesterol lowering targets. J Health Serv Res Policy. 2008;13(2):99-102.
Fox KM, Gandhi SK, Ohsfeldt RL, Davidson MH. Comparison of low-density lipoprotein cholesterol reduction after switching patients on other statins to rosuvastatin or simvastatin in a real-world clinical practice setting. Am J Manag Care. 2007;13 Suppl 10:S270-5.
Newman CB, Palmer G, Silbershatz H, Szarek M. Safety of atorvastatin derived from analysis of 44 completed trials in 9416 patients. Am J Cardiol 2003;92:670-6.
Pasternak RC, Smith SC, Bairey-Merz CN, et al. ACC/AHA/NHLBI clinical advisory on the use and safety of statins. Stroke 2002;33: 2337-41.
Nakad A, Bataille I, Hamoir V, Sempoux C, Horsmans Y. Atorvastatin-induced acute hepatitis with absence of cross-toxicity with simvastatin. Lancet, 1999, 353: 1763-1764.
Dresser GK, Spence JD, Bailey D.G. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome p450 3A4 inhibition. Clin. Pharmacokinet., 2000, 38: 41-57.
Tonolo G, Melis MG, Formato M, et al. Additive effects of simvastatin beyond its effects on LDL cholesterol in hypertensive type 2 diabetic patients. Eur J Clin Invest 2000;30:980-7.
Kostapanos M, Milionis H, Gazi I, et al. Rosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemia. J Clin Pharmacology 2006;46(11):1337-43.
van Zyl-Smit R, Firth JC, Duffield M, Marais AD. Renal tubular toxicity of HMG-CoA reductase inhibitors. Nephrol Dial Transplant 2004;19:3176-9.
Tonolo G, Ciccarese M, Brizzi P, et al. Reduction of albumin excretion rate in normotensive microalbuminuric type 2 diabetic patients during long-term simvastatin treatment. Diabetes Care 1997;20:1891-5.
Vidt DG, Cressman MD, Harris S, Pears JS, Hutchinson HG. Rosuvastatin-induced arrest in progression of renal disease. Cardiology 2004;102:52-60.
El-Hajj II, Mourad FH, Shabb NS, Barada KA. Atorvastatin-induced severe gastric ulceration: a case report. World J Gastroenterol 2005;11:3159-60.
Batey RG, Harvey M. Cholestasis associated with the use of pravastatin sodium. Med J Aust 2002;176:561.
Yoshida EM, Levin A. Lovastatin and cholestasis. CMAJ 1993;148:374.
Rea WE, Durrant DC, Boldy DA. Ulcerative colitis after statin treatment. Postgrad Med J 2002;78:286-7.
Miltiadous G, Anthopoulou A, Elisaf M. Acute pancreatitis possibly associated with combined salicylate and atorvastatin therapy. JOP 2003;4:20-1.
Tysk C, Al-Eryani AY, Shawabkeh AA. Acute pancreatitis induced by fluvastatin therapy. J Clin Gastroenterol 2002;35:406-8.
Pezzilli R, Ceciliato R, Corinaldesi R, Barakat B. Acute pancreatitis due to simvastatin therapy: increased severity after rechallenge. Dig Liver Dis 2004;36:639-40.
Johnson JL, Loomis IB. A case of simvastatin-associated pancreatitis and review of statin-associated pancreatitis. Pharmacotherapy 2006;26:414-22.
Singh S, Nautiyal A, Dolan JG. Recurrent acute pancreatitis possibly induced by atorvastatin and rosuvastatin. Is statin induced pancreatitis a class effect? JOP 2004;5:502-4.
Lons T, Chousterman M. Simvastatin: a new drug responsible for acute pancreatitis? Gastroenterol Clin Biol 1991;15:93-4.
Belaiche G, Ley G, Slama JL. Acute pancreatitis associated with atorvastatin therapy. Gastroenterol Clin Biol 2000;24:471-2.
Anagnostopoulos GK, Tsiakos S, Margantinis G, Kostopoulos P, Arvanitidis D. Acute pancreatitis due to pravastatin therapy. JOP 2003;4:129-32.
Bousquet E, Amar J, Salvador M, Chamontin B. Cataract and simvastatin: case report. Therapie 1998;53:505-507.
Schlienger RG, Haefeli WE, Jick H, Meier CR. Risk of cataract in patients treated with statins. Arch Intern Med 2001;161:2021-6.
Smeeth L, Hubbard R, Fletcher AE. Cataract and the use of statins: a case–control study. QJM 2003;96:337-43.
Klein BE, Klein R, Lee KE, Grady LM. Statin use and incident nuclear cataract. JAMA 2006;295:2752-8.
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