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Rojas Jiménez, S. ., Lopera Valle, J. S. ., Uribe Ocampo, A. ., Correa Pérez, S. ., Perilla Hernández, N. ., & Marín Cárdenas, J. S. . (2015). Consumo de nutracéuticos, una alternativa en la prevención de las enfermedades crónicas no transmisibles. Biosalud, 14(2), 91–103. https://doi.org/10.17151/biosa.2015.14.2.9
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El conocimiento de la fisiopatología de enfermedades crónicas no transmisibles ha hecho que la dieta, los estilos de vida saludables y el autocuidado hagan parte de las estrategias para su prevención, esto se debe a que la terapéutica farmacológica tradicional puede traer consigo efectos adversos no deseados, por lo que se prefieren nuevas alternativas menos lesivas, más seguras y con la misma efectividad. Con base en lo anterior, se hace uso de diferentes estrategias para dar a conocer los efectos benéficos que los nutracéuticos le pueden brindar a la salud de sus consumidores, sus funciones fisiológicas y el tratamiento de enfermedades; pero sin duda alguna el aumento progresivo del consumo de estos suplementos ha generado preguntas sin resolver en la comunidad y el gremio médico sobre la real composición, los efectos fisiológicos y adversos que estos productos puedan tener para la población en general.
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1. Braithwaite M, Tyagi C, Tomar L, Kumar P, Choonara Y, Pillay V. Nutraceutical-based therapeutics and formulation strategies augmenting their efficiency to complement modern medicine: An overview. J Funct Foods 2014; 6:82-9.
2. ElAgouria G, ElAmrawya F, ElYazbib A, Eshraa A, Nounoua M. Male enhancement Nutraceuticals in the Middle East market: Claim, pharmaceutical quality and safety assessments. Int J Pharm 2015; 492:109-19.
3. De Silva A, Lanerolle P. Nutraceuticals: concepts and controversies. Ceylon Med J 2011; 56(4):171-73.
4. González A, Larrosa M, García M, Tomás A, Espín JC. Nutraceuticals for older people: Facts, fictions and gaps in knowledge. Maturitas 2013; 75:313-34.
5. Rajasekaran A, Sivagnanam G, Xavier R. Nutraceuticals as therapeutic agents: A Review. ResearchJ Pharm and Tech 2008; 1(4):328-40.
6. Glosario de términos nutriológicos. Cuadernos de nutrición 2001; 24(1):1-14.
7. Das L, Bhaumik E, Raychaudhuri U, Chakraborty R. Role of nutraceuticals in human health. J Food Sci Technol 2012; 49(2):173-83.
8. Loya AM, González-Stuart A, Rivera JO. Prevalence of polypharmacy, polyherbacy, nutritional supplement use and potential product interactions among older adults living on the United StatesMexico border: a descriptive, questionnaire-based study. Drugs Aging 2009; 26(5):423-36.
9. Ben-Arye E, Polliack A, Schiff E, Tadmor T, Samuels N. Advising Patients on the use of non-herbal nutritional supplements during cancer therapy: A need for doctor-patient communication. J Pain Symptom Manage 2013; 46(6):887-96.
10. Balcerczyk A, Gajewska A, Macierzyńska-Piotrowska E, Pawelczyk T, Bartosz G, Szemraj J. Enhanced antioxidant capacity and anti-ageing biomarkers after diet micronutrient supplementation. Molecules 2014; 19(9):14794-808.
11. Beauman C, Cannon G, Elmadfa I, Glasauer P, Hoffmann I, Keller M, et al. The principles, definition and dimensions of the new nutrition science. Public Health Nutr 2005; 8(6A):695-8.
12. Myung SK, Ju W, Cho B, Oh SW, Park SM, Koo BK, et al. Korean Meta-Analysis Study Group. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. BMJ 2013; 346:f10.
13. Silencia JL. Nutracéuticos. Nutri Informate 2006; 11(4):11-12.
14. Carrasco-Gallardo C, Farías GA, Fuentes P, Crespo F, Maccioni RB. Can nutraceuticals prevent Alzheimer’s disease? Potential therapeutic role of a formulation containing shilajit and complex Bvitamins. Arch Med Res 2012; 43(8):699-704.
15. Aparo L, di Costanzo M, di Scala C, Cosenza L, Leone L, Nocerino R, Canani RB. The influence of early life nutrition on epigenetic regulatory mechanisms of the immune system. Nutrients 2014; 6(11):4706-19.
16. Lakshmana S, Suriya Prakash TNK, Dinesh C, Suresh Kumar S, Ragavendran T. Nutraceuticals: A review. Elixir Pharmacy 2012; 46:8372-77.
17. Keservani RK, Kesharwani RK, Vyas N, Jain S, Raghuvanshi R, Sharma AK. Nutraceutical and Functional Food as Future Food: A Review. Der Pharmacia Lettre 2010; 2(1):106-11.
18. Sloan AE. The top 10 functional food trends. Food Technol 2000; 54(4):33-62.
19. Gupta C, Prakash D. Nutraceuticals for geriatrics. Afr J Tradit Complement Altern Med 2015; 5:5-14.
20. Aruoma O. Functional nutraceuticals. Toxicology 2010; 278:2-5.
21. Dickinson A, Shao A, Boyon N, Franco JC. Use of dietary supplements by cardiologists, dermatologists and orthopedists: report of a survey. Nutr J 2011; 10:20-5.
22. Zlotogorski A, Dayan A, Dayan D, Chaushu G, Salo T, Vered M. Nutraceuticals as new treatment approaches for oral cancer: II. Green tea extracts and resveratrol. Oral Oncology 2013;
49:502-6.
23. Kuppusamya P, Yusoffa M, Maniama G, Jauhari G, Soundharrajanc I, Govindana N. Nutraceuticals as potential therapeutic agents for colon cancer: a review. Acta Pharmaceutica Sinica B 2014; 4(3):173-81.
24. Schernhammer E, Wolpin B, Rifai N, Cochrane B, Manson JA, Ma J, et al. Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. Cancer Res 2007; 67(11):5553-60.
25. Mendoza M, Díaz L, González M, Martínez I, García J, Prado H, et al. Calcitriol and its analogues enhance the antiproliferative activity of gefitinib in breast cancer cells. J Steroid Biochem Mol Biol 2015; 148:122-31.
26. Meeran SM, Katiyar SK. Cell cycle control as a basis for cancer chemoprevention through dietary agents. Front Biosci 2008; 13:2191-202.
27. Valenzuela R, Tapia G, González M, Valenzuela A. Ácidos grasos omega-3 (EPA Y DHA) y su aplicación en diversas situaciones clínicas. Rev Chil Nutr 2011; 38(3):356-67.
28. Serban D. Gastrointestinal cancers: Influence of gut microbiota, probiotics and prebiotics. Cancer Letters 2014; 345:258-70.
29. Dilna S, Surya H, Aswathy R, Varsha K, Sakthikumar D, Pandey A, et al. Characterization of an exopolysaccharide with potential health-benefit properties from a probiotic Lactobacillus plantarum. LWT - Food Science and Technology 2015; 64:1179-86.
30. Femia AP, Luceri C, Dolara P, Giannini A, Biggeri A, Salvadori M, et al. Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 2002; 23(11):1953-60.
31. Bultman SJ. Emerging roles of the microbiome in cancer. Carcinogenesis 2014; 35(2):249-55.
32. Chen ZY, Jiao R, Ma KY. Cholesterol-lowering nutraceuticals and functional foods. J Agric Food Chem 2008; 56(19):8761-73.
33. Cicero A, Parini A, Rosticci M. Nutraceuticals and cholesterol-lowering action. IJC Metabolic & Endocrine 2015; 6:1-4.
34. Palozza P, Catalano A, Simone RE, Mele MC, Cittadini A. Effect of lycopene and tomato products on cholesterol metabolism. Ann Nutr Metab 2012; 61(2):126-34.
35. Mannarino M, Ministrini S, Pirro M. Nutraceuticals for the treatment of hypercholesterolemia. Eur J Intern Med 2014; 25: 592-99.
36. García-Ríos A, Delgado-Lista J, Alcalá-Díaz JF, López-Miranda J, Pérez-Martínez P. Nutraceuticals and coronary heart disease. Curr Opin Cardiol 2013; 28(4):475-82.
37. Barter P, Ginsberg HN. Effectiveness of combined statin plus omega-3 fatty acid therapy for mixed dyslipidemia. Am J Cardiol 2008; 102(8):1040-5.
38. Gisondi P, Fantuzzi F, Malerba M, Girolomoni G. Folic acid in general medicine and dermatology. J Dermatolog Treat 2007; 18(3):138-46.
39. Roży A, Jaguś P, Chorostowska-Wynimko J. Probiotics in the prevention and treatment of allergic diseases. Pneumonol Alergol Pol 2012; 80(1):65-76.
40. Murzaku E, Bronsnick T, Rao B. Diet in dermatology Part II. Melanoma, chronic urticaria, and psoriasis. J Am Acad Dermato 2014; 71(6):1053.e1-e16.
41. De Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol 2008; 111:1-66.
42. Nishihara T, Suzuki N, Yoneda M, Hirofuji T. Effects of Lactobacillus salivarius-containing tablets on caries risk factors: a randomized open-label clinical trial. BMC Oral Health 2014;
14:110-17.
43. Teughels W, Van Essche M, Sliepen I, Quirynen M. Probiotics and oral healthcare. Periodontol 2000. 2008; 48:111-47.
44. Ringel Y, Ringel-Kulka T. The rationale and clinical effectiveness of probiotics in irritable bowel syndrome. J Clin Gastroenterol 2011; 45(suppl):S145-8.
45. Spiller R. Review article: probiotics and prebiotics in irritable bowel syndrome. Aliment Pharmacol Ther 2008; 28(4):385-96.
46. Chan SS, Luben R, Olsen A, Tjonneland A, Kaaks R, Lindgren S, et al. Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn’s disease. Aliment Pharmacol Ther 2014; 39(8):834-42.
47. Bottegoni C, Muzzarelli R, Giovannini A, Busilacchi A, Gigante A. Oral chondroprotection with nutraceuticals made of chondroitin sulphate plus glucosamine sulphate in osteoarthritis. J Carpol 2014; 109:126-38.
48. Castillo-Lancellotti C, Tur JA, Uauy R. Suplementación con ácido fólico y prevención de recurrencia de adenomas colorrectales; revisión sistemática. Nutr Hosp 2012; 27(1):13-21
49. Ogundipe O, Hoyo C, Ostbye T, Oneko O, Manongi R, Lie RT, et al. Factors associated with prenatal folic acid and iron supplementation among 21,889 pregnant women in Northern Tanzania: a crosssectional hospital-based study. BMC Public Health 2012; 12:481.
50. Estrategia AIEPI, Atención integrada a las enfermedades prevalentes de la infancia. Cuadro de procedimientos. Bogotá: Organización Panamericana de la Salud, Ministerio de la Protección Social de Colombia; 2010.
51. Clavijo HA, Fajardo LF. Neurobiología, alimentación y vida saludable: parte I. Nutracéutica. Revista Suma Digital de Psicología 2009; 3:55-75.
52. Dagerman M. Incentivizing safety in the dietary supplement industry. Review of Litigation 2012; 31(1):173-345.
53. Ashar BH, Rowland-Seymour A. Advising patients who use dietary supplements. Am J Med 2008; 121(2):91-7.
54. Rovira M, Grau M, Castaner O, Covas M, Schroder H. Dietary Supplement Use and Health-Related Behaviors in a Mediterranean Population. J Nutr Educ Behav 2013; 45:386-91.
55. Weiss LA, Chambers CD. Associations between multivitamin supplement use and alcohol consumption before pregnancy: Pregnancy Risk Assessment Monitoring System, 2004 to 2008. Alcohol Clin Exp Res 2013; 37(9):1595-600.
56. Cancio A, Eliason MJ, Mercer J, Tran T, Deuster PA, Stephens MB. Third-party certification of dietary supplements: prevalence and concerns. Mil Med 2012; 177(12):1460-3.
57. Kalichman SC, Cherry C, White D, Jones M, Kalichman MO, Detorio MA. Use of dietary supplements among people living with HIV/AIDS is associated with vulnerability to medical misinformation on the internet. AIDS Res Ther 2012; 9(1):1.
58. Sousa M, Fernandes M, Carvalho P, Soares J, Moreira P, Teixeira V. Nutritional supplements use in high-performance athletes is related with lower nutritional inadequacy from food. J Sport Health Sci 2015; 1:1-7.
59. Dickinson A, MacKay D. Health habits and other characteristics of dietary supplement users: a review. Nutr J 2014; 13:14-26.
60. Albright CL, Schembre SM, Steffen AD, Wilkens LR, Monroe KR, Yonemori KM, et al. Differences by race/ethnicity in older adults’ beliefs about the relative importance of dietary supplements vs prescription medications: results from the SURE Study. J Acad Nutr Diet 2012; 112(8):1223-9.
61. Rizzo T. Multivitamins for the Prevention of Cardiovascular Disease in Men. MD Conference Express 2012; 11-12.
62. Da Justa D, Dutra E. Dietary supplements: International legal framework and adulteration profiles, and characteristics of products on the Brazilian clandestine market. Regul. Toxicol. Pharmacol. 2015; 73:93-104.
63. Van der Horst K, Siegrist M. Vitamin and mineral supplement users. Do they have healthy or unhealthy dietary behaviours? Appetite 2011; 57(3):758-64.
64. Giammarioli S, Boniglia C, Carratù B, Ciarrocchi M, Chiarotti F, Mosca M, Sanzini E. Use of food supplements and determinants of usage in a sample Italian adult population. Public Health Nutr 2013; 16(10):1768-81.
65. Bailey RL, Fulgoni VL 3rd, Keast DR, Dwyer JT. Examination of vitamin intakes among US adults by dietary supplement use. J Acad Nutr Diet 2012; 112(5):657-663.
66. Farina E, Austin C, Lieberman H. Concomitant dietary supplement and prescription medication use is prevalent among US adults with doctor-informed medical conditions. J Acad Nutr Diet 2014; 114(11):1784- 90.e2.
67. Ministerio de la Protección Social. Decreto 3249 del 18 de septiembre de 2006. Por el cual se reglamenta la fabricación, comercialización, envase, rotulado o etiquetado, régimen de registro sanitario, de control de calidad, de vigilancia sanitaria y control sanitario de los suplementos dietarios, se dictan otras disposiciones y se deroga el Decreto 3636 de 2005.
68. Guevara HA, Luengas PE, Garavito G. Revisión documental de los productos naturales legalmente autorizados para su mercadeo en Colombia. Colomb. Med. 2010; 41(2):129-140.
69. Teschke R, Frenzel C, Schulze J, Schwarzenboeck A, Eickhoff A. Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests. World J Hepatol 2013; 5(7):353-63.
70. Dodge T, Litt D, Kaufman A. Influence of the dietary supplement health and education act on consumer beliefs about the safety and effectiveness of dietary supplements. J Health Commun 2011; 16(3):230-44.
2. ElAgouria G, ElAmrawya F, ElYazbib A, Eshraa A, Nounoua M. Male enhancement Nutraceuticals in the Middle East market: Claim, pharmaceutical quality and safety assessments. Int J Pharm 2015; 492:109-19.
3. De Silva A, Lanerolle P. Nutraceuticals: concepts and controversies. Ceylon Med J 2011; 56(4):171-73.
4. González A, Larrosa M, García M, Tomás A, Espín JC. Nutraceuticals for older people: Facts, fictions and gaps in knowledge. Maturitas 2013; 75:313-34.
5. Rajasekaran A, Sivagnanam G, Xavier R. Nutraceuticals as therapeutic agents: A Review. ResearchJ Pharm and Tech 2008; 1(4):328-40.
6. Glosario de términos nutriológicos. Cuadernos de nutrición 2001; 24(1):1-14.
7. Das L, Bhaumik E, Raychaudhuri U, Chakraborty R. Role of nutraceuticals in human health. J Food Sci Technol 2012; 49(2):173-83.
8. Loya AM, González-Stuart A, Rivera JO. Prevalence of polypharmacy, polyherbacy, nutritional supplement use and potential product interactions among older adults living on the United StatesMexico border: a descriptive, questionnaire-based study. Drugs Aging 2009; 26(5):423-36.
9. Ben-Arye E, Polliack A, Schiff E, Tadmor T, Samuels N. Advising Patients on the use of non-herbal nutritional supplements during cancer therapy: A need for doctor-patient communication. J Pain Symptom Manage 2013; 46(6):887-96.
10. Balcerczyk A, Gajewska A, Macierzyńska-Piotrowska E, Pawelczyk T, Bartosz G, Szemraj J. Enhanced antioxidant capacity and anti-ageing biomarkers after diet micronutrient supplementation. Molecules 2014; 19(9):14794-808.
11. Beauman C, Cannon G, Elmadfa I, Glasauer P, Hoffmann I, Keller M, et al. The principles, definition and dimensions of the new nutrition science. Public Health Nutr 2005; 8(6A):695-8.
12. Myung SK, Ju W, Cho B, Oh SW, Park SM, Koo BK, et al. Korean Meta-Analysis Study Group. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. BMJ 2013; 346:f10.
13. Silencia JL. Nutracéuticos. Nutri Informate 2006; 11(4):11-12.
14. Carrasco-Gallardo C, Farías GA, Fuentes P, Crespo F, Maccioni RB. Can nutraceuticals prevent Alzheimer’s disease? Potential therapeutic role of a formulation containing shilajit and complex Bvitamins. Arch Med Res 2012; 43(8):699-704.
15. Aparo L, di Costanzo M, di Scala C, Cosenza L, Leone L, Nocerino R, Canani RB. The influence of early life nutrition on epigenetic regulatory mechanisms of the immune system. Nutrients 2014; 6(11):4706-19.
16. Lakshmana S, Suriya Prakash TNK, Dinesh C, Suresh Kumar S, Ragavendran T. Nutraceuticals: A review. Elixir Pharmacy 2012; 46:8372-77.
17. Keservani RK, Kesharwani RK, Vyas N, Jain S, Raghuvanshi R, Sharma AK. Nutraceutical and Functional Food as Future Food: A Review. Der Pharmacia Lettre 2010; 2(1):106-11.
18. Sloan AE. The top 10 functional food trends. Food Technol 2000; 54(4):33-62.
19. Gupta C, Prakash D. Nutraceuticals for geriatrics. Afr J Tradit Complement Altern Med 2015; 5:5-14.
20. Aruoma O. Functional nutraceuticals. Toxicology 2010; 278:2-5.
21. Dickinson A, Shao A, Boyon N, Franco JC. Use of dietary supplements by cardiologists, dermatologists and orthopedists: report of a survey. Nutr J 2011; 10:20-5.
22. Zlotogorski A, Dayan A, Dayan D, Chaushu G, Salo T, Vered M. Nutraceuticals as new treatment approaches for oral cancer: II. Green tea extracts and resveratrol. Oral Oncology 2013;
49:502-6.
23. Kuppusamya P, Yusoffa M, Maniama G, Jauhari G, Soundharrajanc I, Govindana N. Nutraceuticals as potential therapeutic agents for colon cancer: a review. Acta Pharmaceutica Sinica B 2014; 4(3):173-81.
24. Schernhammer E, Wolpin B, Rifai N, Cochrane B, Manson JA, Ma J, et al. Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. Cancer Res 2007; 67(11):5553-60.
25. Mendoza M, Díaz L, González M, Martínez I, García J, Prado H, et al. Calcitriol and its analogues enhance the antiproliferative activity of gefitinib in breast cancer cells. J Steroid Biochem Mol Biol 2015; 148:122-31.
26. Meeran SM, Katiyar SK. Cell cycle control as a basis for cancer chemoprevention through dietary agents. Front Biosci 2008; 13:2191-202.
27. Valenzuela R, Tapia G, González M, Valenzuela A. Ácidos grasos omega-3 (EPA Y DHA) y su aplicación en diversas situaciones clínicas. Rev Chil Nutr 2011; 38(3):356-67.
28. Serban D. Gastrointestinal cancers: Influence of gut microbiota, probiotics and prebiotics. Cancer Letters 2014; 345:258-70.
29. Dilna S, Surya H, Aswathy R, Varsha K, Sakthikumar D, Pandey A, et al. Characterization of an exopolysaccharide with potential health-benefit properties from a probiotic Lactobacillus plantarum. LWT - Food Science and Technology 2015; 64:1179-86.
30. Femia AP, Luceri C, Dolara P, Giannini A, Biggeri A, Salvadori M, et al. Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 2002; 23(11):1953-60.
31. Bultman SJ. Emerging roles of the microbiome in cancer. Carcinogenesis 2014; 35(2):249-55.
32. Chen ZY, Jiao R, Ma KY. Cholesterol-lowering nutraceuticals and functional foods. J Agric Food Chem 2008; 56(19):8761-73.
33. Cicero A, Parini A, Rosticci M. Nutraceuticals and cholesterol-lowering action. IJC Metabolic & Endocrine 2015; 6:1-4.
34. Palozza P, Catalano A, Simone RE, Mele MC, Cittadini A. Effect of lycopene and tomato products on cholesterol metabolism. Ann Nutr Metab 2012; 61(2):126-34.
35. Mannarino M, Ministrini S, Pirro M. Nutraceuticals for the treatment of hypercholesterolemia. Eur J Intern Med 2014; 25: 592-99.
36. García-Ríos A, Delgado-Lista J, Alcalá-Díaz JF, López-Miranda J, Pérez-Martínez P. Nutraceuticals and coronary heart disease. Curr Opin Cardiol 2013; 28(4):475-82.
37. Barter P, Ginsberg HN. Effectiveness of combined statin plus omega-3 fatty acid therapy for mixed dyslipidemia. Am J Cardiol 2008; 102(8):1040-5.
38. Gisondi P, Fantuzzi F, Malerba M, Girolomoni G. Folic acid in general medicine and dermatology. J Dermatolog Treat 2007; 18(3):138-46.
39. Roży A, Jaguś P, Chorostowska-Wynimko J. Probiotics in the prevention and treatment of allergic diseases. Pneumonol Alergol Pol 2012; 80(1):65-76.
40. Murzaku E, Bronsnick T, Rao B. Diet in dermatology Part II. Melanoma, chronic urticaria, and psoriasis. J Am Acad Dermato 2014; 71(6):1053.e1-e16.
41. De Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol 2008; 111:1-66.
42. Nishihara T, Suzuki N, Yoneda M, Hirofuji T. Effects of Lactobacillus salivarius-containing tablets on caries risk factors: a randomized open-label clinical trial. BMC Oral Health 2014;
14:110-17.
43. Teughels W, Van Essche M, Sliepen I, Quirynen M. Probiotics and oral healthcare. Periodontol 2000. 2008; 48:111-47.
44. Ringel Y, Ringel-Kulka T. The rationale and clinical effectiveness of probiotics in irritable bowel syndrome. J Clin Gastroenterol 2011; 45(suppl):S145-8.
45. Spiller R. Review article: probiotics and prebiotics in irritable bowel syndrome. Aliment Pharmacol Ther 2008; 28(4):385-96.
46. Chan SS, Luben R, Olsen A, Tjonneland A, Kaaks R, Lindgren S, et al. Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn’s disease. Aliment Pharmacol Ther 2014; 39(8):834-42.
47. Bottegoni C, Muzzarelli R, Giovannini A, Busilacchi A, Gigante A. Oral chondroprotection with nutraceuticals made of chondroitin sulphate plus glucosamine sulphate in osteoarthritis. J Carpol 2014; 109:126-38.
48. Castillo-Lancellotti C, Tur JA, Uauy R. Suplementación con ácido fólico y prevención de recurrencia de adenomas colorrectales; revisión sistemática. Nutr Hosp 2012; 27(1):13-21
49. Ogundipe O, Hoyo C, Ostbye T, Oneko O, Manongi R, Lie RT, et al. Factors associated with prenatal folic acid and iron supplementation among 21,889 pregnant women in Northern Tanzania: a crosssectional hospital-based study. BMC Public Health 2012; 12:481.
50. Estrategia AIEPI, Atención integrada a las enfermedades prevalentes de la infancia. Cuadro de procedimientos. Bogotá: Organización Panamericana de la Salud, Ministerio de la Protección Social de Colombia; 2010.
51. Clavijo HA, Fajardo LF. Neurobiología, alimentación y vida saludable: parte I. Nutracéutica. Revista Suma Digital de Psicología 2009; 3:55-75.
52. Dagerman M. Incentivizing safety in the dietary supplement industry. Review of Litigation 2012; 31(1):173-345.
53. Ashar BH, Rowland-Seymour A. Advising patients who use dietary supplements. Am J Med 2008; 121(2):91-7.
54. Rovira M, Grau M, Castaner O, Covas M, Schroder H. Dietary Supplement Use and Health-Related Behaviors in a Mediterranean Population. J Nutr Educ Behav 2013; 45:386-91.
55. Weiss LA, Chambers CD. Associations between multivitamin supplement use and alcohol consumption before pregnancy: Pregnancy Risk Assessment Monitoring System, 2004 to 2008. Alcohol Clin Exp Res 2013; 37(9):1595-600.
56. Cancio A, Eliason MJ, Mercer J, Tran T, Deuster PA, Stephens MB. Third-party certification of dietary supplements: prevalence and concerns. Mil Med 2012; 177(12):1460-3.
57. Kalichman SC, Cherry C, White D, Jones M, Kalichman MO, Detorio MA. Use of dietary supplements among people living with HIV/AIDS is associated with vulnerability to medical misinformation on the internet. AIDS Res Ther 2012; 9(1):1.
58. Sousa M, Fernandes M, Carvalho P, Soares J, Moreira P, Teixeira V. Nutritional supplements use in high-performance athletes is related with lower nutritional inadequacy from food. J Sport Health Sci 2015; 1:1-7.
59. Dickinson A, MacKay D. Health habits and other characteristics of dietary supplement users: a review. Nutr J 2014; 13:14-26.
60. Albright CL, Schembre SM, Steffen AD, Wilkens LR, Monroe KR, Yonemori KM, et al. Differences by race/ethnicity in older adults’ beliefs about the relative importance of dietary supplements vs prescription medications: results from the SURE Study. J Acad Nutr Diet 2012; 112(8):1223-9.
61. Rizzo T. Multivitamins for the Prevention of Cardiovascular Disease in Men. MD Conference Express 2012; 11-12.
62. Da Justa D, Dutra E. Dietary supplements: International legal framework and adulteration profiles, and characteristics of products on the Brazilian clandestine market. Regul. Toxicol. Pharmacol. 2015; 73:93-104.
63. Van der Horst K, Siegrist M. Vitamin and mineral supplement users. Do they have healthy or unhealthy dietary behaviours? Appetite 2011; 57(3):758-64.
64. Giammarioli S, Boniglia C, Carratù B, Ciarrocchi M, Chiarotti F, Mosca M, Sanzini E. Use of food supplements and determinants of usage in a sample Italian adult population. Public Health Nutr 2013; 16(10):1768-81.
65. Bailey RL, Fulgoni VL 3rd, Keast DR, Dwyer JT. Examination of vitamin intakes among US adults by dietary supplement use. J Acad Nutr Diet 2012; 112(5):657-663.
66. Farina E, Austin C, Lieberman H. Concomitant dietary supplement and prescription medication use is prevalent among US adults with doctor-informed medical conditions. J Acad Nutr Diet 2014; 114(11):1784- 90.e2.
67. Ministerio de la Protección Social. Decreto 3249 del 18 de septiembre de 2006. Por el cual se reglamenta la fabricación, comercialización, envase, rotulado o etiquetado, régimen de registro sanitario, de control de calidad, de vigilancia sanitaria y control sanitario de los suplementos dietarios, se dictan otras disposiciones y se deroga el Decreto 3636 de 2005.
68. Guevara HA, Luengas PE, Garavito G. Revisión documental de los productos naturales legalmente autorizados para su mercadeo en Colombia. Colomb. Med. 2010; 41(2):129-140.
69. Teschke R, Frenzel C, Schulze J, Schwarzenboeck A, Eickhoff A. Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests. World J Hepatol 2013; 5(7):353-63.
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