DOI: 10.17151/biosa.2017.16.1.8
Cómo citar
Serrano Díaz, N. ., Guío Mahecha, E. ., González, A. ., Plata Paredes, L. ., Quintero Lesmes, D. C. ., & Becerra Bayona, S. . (2017). Cuantificación de vitamina D: de la investigación a la práctica clínica. Biosalud, 16(1), 67–79.


Norma Serrano Díaz
Investigador Asociado (UNAB)
Elizabeth Guío Mahecha
Laboratorio de Medicina Genómica y Metabolismo HIC-FCV
Alejandra González
Laboratorio de Medicina Genómica y Metabolismo HIC-FCV
Laura Plata Paredes
Laboratorio de Medicina Genómica y Metabolismo HIC-FCV
Doris Cristina Quintero Lesmes
Grupo de investigación Estudios Epidemiológicos y de Salud Pública – FCV
Silvia Becerra Bayona
Universidad Autónoma de Bucaramanga (UNAB)


Las formas biológicamente activas de la vitamina D se han convertido en elementos de gran relevancia en la práctica clínica y la investigación, por lo tanto, su análisis se ha incrementado en años recientes. La vitamina D tiene un papel esencial en la regulación del metabolismo del calcio y fósforo; adicionalmente, esta vitamina es considerada un posible factor preventivo para diversas enfermedades crónicas como la diabetes mellitus tipo 2, algunos tipos de cáncer, cardiovasculares, autoinmunes, enfermedad pulmonar obstructiva crónica y la pre-eclampsia. Debido al posible papel en estas enfermedades y a los pocos estudios comparativos que se han realizado entre éstas y los niveles de vitamina D, los investigadores y clínicos están interesados en usar técnicas confiables y específicas que permitan determinar las concentraciones de vitamina D en el plasma. Sin embargo, no se ha establecido cuál es el mejor biomarcador que refleja la suficiencia de vitamina D y su función, ni tampoco cuál es la mejor técnica para su adecuada cuantificación. El objetivo de esta revisión es describir brevemente el metabolismo de la vitamina D y los retos que existen para su adecuada cuantificación con fines de investigación traslacional.

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