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Publication Date: 2006-01-01
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Bouso Saiz, J. C. . (2006). Yagé: ¿un adaptógeno biológico específico?. Cultura Y Droga, 11(13), 55–74. Retrieved from https://revistasojs.ucaldas.edu.co/index.php/culturaydroga/article/view/5985
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Abstract
Abstract: In the hippocampus a continuous cellular proliferation and neurogenesis are produced during the whole vital period. Due to the importance of the hippocampus in the active modulation of the emotional and cognitive processes, it has been speculated that the hippocampal neurogenesis responds to a cerebral neuroadaptive mechanism to adjust to changing environments. Additionally, it has been demonstrated that the pharmacological activation of the -HT1A and 5-HT2A receptors, which are the principal cerebral receptors on which the yagé acts upon, induce neurogenesis in some concrete areas of the central nervous system, principally in the hippocampus. This article speculates on the possibility that a continuous intake of yagé can benefit the cultural adaptation of individuals to their environment, not so much due to the visions it creates, but because of the underlying biological mechanisms that its consumption creates.
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References
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Da Silveira D.X., Grob C.S., De Rios M.D., Lopez E., Alonso L.K., Tacla C., Doering-Silveira E. Ayahuasca in adolescence: a preliminary psychiatric assessment. J Psychoactive Drugs. 2005 Jun; 37(2): 129-33.
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Kempermann G., Kronenberg G. Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol. Psychiatry. 2003 Sep 1; 54(5): 499-503.
Kempermann G., Wiskott L., Gage F.H. Functional significance of adult neurogenesis. Curr Opin Neurobiol. 2004 Apr; 14(2): 186-91.
Labate, B. A reinvençao do uso da ayahuasca nos centros urbanos. Campinas: Mercado de Letras, 2004.
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Malberg J.E., Eisch A.J., Nestler E.J., Duman R.S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci. 2000 Dec 15; 20(24): 9104-10.
Malberg J.E., Duman R.S. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep; 28(9): 1562-71.
Mancheño E. y Jiménez M. ¿Es posible la reparación del cerebro? Mente y cerebro 2005 Nov/Dic; 15: 34-49.
Metzner R. (Ed.). Ayahuasca: Human consciousness and the spirits of nature. New York, NY: Thunder’s Mouth Pr, 1999.
Ott J. Análogos de la ayahuasca. Madrid: Amargord, 2006.
Radley J.J., Jacobs B.L. 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus. Brain Res. 2002 Nov 15; 955(1-2): 264-7.
Riba J., Valle M., Urbano G., Yritia M., Morte A., Barbanoj M.J. Human pharmacology of ayahuasca: subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics. J Pharmacol Exp Ther. 2003 Jul; 306(1): 73-83.
Ronderos J. Chamanismos, neochamanismos y la medicina tradicional del yagé en el Eje Cafetero. Cultura y Droga. 2003 8(10): 83-118.
Santarelli L., Saxe M., Gross C., Surget A., Battaglia F., Dulawa S., Weisstaub N., Lee J., Duman R., Arancio O., Belzung C., Hen R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science. 2003 Aug 8; 301(5634): 805-9.
Saplosky R. Why stress is bad for your brain? Science. 273: 749-750. Sheline Y.I. 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biol Psychiatry. 2000 Oct 15; 48(8): 791-800.
Schultes R.E., Hofmann A. (1980). The botany and chemistry of hallucinogens. Charles C. Thomas, Springfield, Illinois.
Strassman R.J. Human psychopharmacology of N,N-dimethyltryptamine. Behav Brain Res. 1996; 73(1-2): 121-4.
____________., Qualls C.R., Berg L.M. Differential tolerance to biological and subjective effects of four closely spaced doses of N,N-dimethyltryptamine in humans. Biol Psychiatry. 1996 May 1; 39(9): 784-95.
Wiskott L., Rasch M.J., Kempermann G. A functional hypothesis for adult hippocampal neurogenesis: avoidance of catastrophic interference in the dentate gyrus. Hippocampus. 2006; 16(3): 329-43.
Yritia M., Riba J., Ortuno J., Ramirez A., Castillo A., Alfaro Y., De La Torre R., Barbanoj M.J. Determination of N,N-dimethyltryptamine and beta-carboline alkaloids in human plasma following oral administration of Ayahuasca. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 5; 779(2): 271-81.
Banasr M., Hery M., Printemps R., Daszuta A. Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology. 2004 Mar; 29(3): 450-60.
Bremner, J., Randall, R., Scott, T., Bronen, R., Seibyl, J., Southwick, S., Delaney, R., Mccarthy, G., Charney, D., Innis, R. (1995). MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. American Journal of Psychiatry, 152: 973-981.
Brezun J.M., Daszuta A. Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats. Neuroscience. 1999; 89(4): 999-1002.
Da Silveira D.X., Grob C.S., De Rios M.D., Lopez E., Alonso L.K., Tacla C., Doering-Silveira E. Ayahuasca in adolescence: a preliminary psychiatric assessment. J Psychoactive Drugs. 2005 Jun; 37(2): 129-33.
Doering-Silveira E., Lopez E., Grob C.S., De Rios M.D., Alonso L.K., Tacla C., Shirakawa I., Bertolucci P.H., Da Silveira D.X. Ayahuasca in adolescence: a neuropsychological assessment. J Psychoactive Drugs. 2005 Jun; 37(2): 123-8.
Duman R.S., Nakagawa S., Malberg J. Regulation of adult neurogenesis by antidepressant treatment. Neuropsychopharmacology. 2001 Dec; 25(6): 836-44. Ebmeier K.P.,
Donaghey C., Steele J.D. Recent developments and current controversies in depression. Lancet. 2006 Jan 14; 367(9505): 153-67.
Eriksson P.S., Perfilieva E., Bjork-Eriksson T., Alborn A.M., Nordborg C., Peterson D.A., Gage F.H. Neurogenesis in the adult human hippocampus. Nat Med. 1998 Nov; 4(11): 1313-7.
Fericgla J.M. “¿Alucinógenos o adpatógenos inespecíficos?”. En: J.M. Fericgla (Ed.): Plantas, chamanismo y estados de conciencia. Barcelona:Los libros de la Liebre de Marzo, 1994.
Frodl T., Meisenzahl E.M., Zetzsche T., Born C., Groll C., Jager M., Leinsinger G., Bottlender R., Hahn K., Moller H.J. Hippocampal changes in patients with a first episode of major depression. Am J Psychiatry. 2002 Jul; 159(7): 1112-8.
Gilbertson M.W., Shenton M.E., Ciszewski A., Kasai K., Lasko N.B., Orr S.P., Pitman R.K.. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci. 2002 Nov; 5(11): 1242-7.
Glennon R.A., Dukat M., Grella B., Hong S., Costantino L., Teitler M., Smith C., Egan C., Davis K., Mattson M.V. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1; 60(2): 121-32.
Gould E. Serotonin and hippocampal neurogenesis. Neuropsychopharmacology. 1999, 21 (2S): 46S-51S.
Gould E., Reeves A.J., Graziano M.S., Gross C.G. Neurogenesis in the neocortex of adult primates. Science. 1999 Oct 15; 286(5439): 548-52.
Grob C.S., Mckenna D.J., Callaway J.C., Brito G.S., Neves E.S., Oberlaender G., Saide O.L., Labigalini E., Tacla C., Miranda C.T., Strassman R.J., Boone
K.B. Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil. J Nerv Ment Dis. 1996 Feb; 184(2): 86-94.
Jacobs B.L. Adult brain neurogenesis and depression. Brain Behav Immun. 2002 Oct; 16(5): 602-9.
Kempermann G.A. Regulation of adult hippocampal neurogenesis - implications for novel theories of major depression. Bipolar Disord. 2002a Feb; 4(1): 17-33. Kempermann G. Why new neurons? Possible functions for adult hippocampal neurogenesis. J Neurosci. 2002b Feb 1; 22(3): 635-8.
Kempermann G., Kronenberg G. Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol. Psychiatry. 2003 Sep 1; 54(5): 499-503.
Kempermann G., Wiskott L., Gage F.H. Functional significance of adult neurogenesis. Curr Opin Neurobiol. 2004 Apr; 14(2): 186-91.
Labate, B. A reinvençao do uso da ayahuasca nos centros urbanos. Campinas: Mercado de Letras, 2004.
Ledoux J. Synaptic self. How our brains become who we are. New York, NY: Penguin books, 2002.
Malberg J.E., Eisch A.J., Nestler E.J., Duman R.S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci. 2000 Dec 15; 20(24): 9104-10.
Malberg J.E., Duman R.S. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep; 28(9): 1562-71.
Mancheño E. y Jiménez M. ¿Es posible la reparación del cerebro? Mente y cerebro 2005 Nov/Dic; 15: 34-49.
Metzner R. (Ed.). Ayahuasca: Human consciousness and the spirits of nature. New York, NY: Thunder’s Mouth Pr, 1999.
Ott J. Análogos de la ayahuasca. Madrid: Amargord, 2006.
Radley J.J., Jacobs B.L. 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus. Brain Res. 2002 Nov 15; 955(1-2): 264-7.
Riba J., Valle M., Urbano G., Yritia M., Morte A., Barbanoj M.J. Human pharmacology of ayahuasca: subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics. J Pharmacol Exp Ther. 2003 Jul; 306(1): 73-83.
Ronderos J. Chamanismos, neochamanismos y la medicina tradicional del yagé en el Eje Cafetero. Cultura y Droga. 2003 8(10): 83-118.
Santarelli L., Saxe M., Gross C., Surget A., Battaglia F., Dulawa S., Weisstaub N., Lee J., Duman R., Arancio O., Belzung C., Hen R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science. 2003 Aug 8; 301(5634): 805-9.
Saplosky R. Why stress is bad for your brain? Science. 273: 749-750. Sheline Y.I. 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biol Psychiatry. 2000 Oct 15; 48(8): 791-800.
Schultes R.E., Hofmann A. (1980). The botany and chemistry of hallucinogens. Charles C. Thomas, Springfield, Illinois.
Strassman R.J. Human psychopharmacology of N,N-dimethyltryptamine. Behav Brain Res. 1996; 73(1-2): 121-4.
____________., Qualls C.R., Berg L.M. Differential tolerance to biological and subjective effects of four closely spaced doses of N,N-dimethyltryptamine in humans. Biol Psychiatry. 1996 May 1; 39(9): 784-95.
Wiskott L., Rasch M.J., Kempermann G. A functional hypothesis for adult hippocampal neurogenesis: avoidance of catastrophic interference in the dentate gyrus. Hippocampus. 2006; 16(3): 329-43.
Yritia M., Riba J., Ortuno J., Ramirez A., Castillo A., Alfaro Y., De La Torre R., Barbanoj M.J. Determination of N,N-dimethyltryptamine and beta-carboline alkaloids in human plasma following oral administration of Ayahuasca. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 5; 779(2): 271-81.
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