PDF (Español)
FLIP
How to Cite
Quiroz Bucheli, A. ., Melo Solarte, D. S. ., & Narváez Solarte, W. (2020). Methodology for the quantification of tibial dyschondroplasia in gallus gallus domesticus (aves : Phasianidae). Boletín Científico. Centro De Museos, 24(1), 76–85. https://doi.org/10.17151/bccm.2020.24.1.5
More Citation Formats
Authors
Abstract
Objective: To compare the efficacy of the score technique of the tibial dyschondroplasia lesions with a quantification technique in broiler chickens, in search of a better objectivity and reliability of the diagnosis. Materials and methods: 384 male one-day-old chickens were raised until day 36. A total of 192 chickens were sampled, 96 at day 21 and 96 at day 36; the tibial dyschondroplasia disorder was evaluated by comparing two techniques: 1. Qualitative evaluation of the score of tibial dyschondroplasia and, 2. Quantitative measurement of the percentage of area with tibial dyschondroplasia as an alternative test. Results: the Score test of TD lesions had a sensitivity of 83% and 100% with a specificity of 55% and 54% for day 21 and day 36 respectively, and a positive predictive value of 60% for day 21 and of 66% for day 36, while the negative predictive value was 80% and 100% for days 21 and 36. Conclusions: The evaluated alternative test proved to be an effective and efficient method of quantification of tibial dyschondroplasia in broiler chickens, offering more objectivity than the traditional macroscopic test.
Keywords:
References
Almeida Paz, I.C.L., Mendes, A.A., Takita, T.S., Vulcano, L.C., Guerra, P.C., Wechsler, F.S., Garcia, R.G., Takahashi, S.E., Moreira, J., Pelícia, K., Komiyama, C.M. & Quinteiro, R.R. (2005). Comparison of techniques for tibial dyschondroplasia assessment in broiler chickens. Brazilian Journal of Poultry, 7(1): 27–31. doi: http://dx.doi.org/10.1590/S1516-635X2005000100005
Edwards, H.M. & Veltmann, J.R. (1983). The role of calcium and phosphorus in the etiology of tibial dyschondroplasia in young chicks. Journal of Nutrition, 113(8): 1568–1575. doi: https://doi.org/10.1093/jn/113.8.1568
Farquharson, C., Loveridge, N., Whitehead, C., Rennie, S., Jakowlew, S. & Thorp, B. (1992). P9. Control of chondrocyte maturation: role of glycosaminoglycans, c-myc and TGFβ in the development of avian tibial dyschondroplasia. Bone, 13(3): 277. doi: https://doi.org/10.1016/8756-3282(92)90228-O
Farquharson, C. & Jefferies, D. (2000). Chondrocytes and Longitudinal Bone Growth: The Development of Tibial Dyschondroplasia. Poultry Science, 79(7): 994–1004. doi: https://doi.org/10.1093/ps/79.7.994
Imik, H., Kapakin, K., Gümüş, R., Kapakin, S. & Kurt, A. (2012). The effect of tibial dyschondroplasia on metabolic parameters in broiler chickens. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 59(1): 271–277. doi: 10.1501/Vetfak_0000002538
Julian, R.J. (1998). Rapid growth problems: ascites and skeletal deformities in broilers. Poultry Science, 77(12): 1773–1780. doi: https://doi.org/10.1093/ps/77.12.1773
Julian, R.J. (2005). Production and growth related disorders and other metabolic diseases of poultry--a review.The Veterinary Journal, 169(3): 350–369. doi: https://doi.org/10.1016/j.tvjl.2004.04.015
Kapakin, K., Kapakin, S., Imik, H., Gumus, R. & Eser, G. (2019). The Investigation of the Relationship Between HSP27 Release and Oxidative DNA Damage in Broiler Chickens with Tibial Dyschondroplasia by Using Histopathological and Immunohistochemical Methods. Brazilian Journal of Poultry, 21(3): 1–6. doi: http://dx.doi.org/10.1590/1806-9061-2019-1091
Mehmood, K., Zhang, H., Li, K., Wang, L., Rehman, M., Nabi, F., …& Li, J. (2018). Effect of tetramethylpyrazine on tibial dyschondroplasia incidence, tibial angiogenesis, performance and characteristics via HIF-1a/VEGF signaling pathway in chickens. Scientific Reports, 8(1):2495. doi: 10.1038/s41598-018-20562-3.
Mrad, A. (2006). Ética en la investigación con modelos animales experimentales. Alternativas y las 3 RS de Russel. Una responsabilidady un compromiso ético que nos compete a todos. Revista Colombiana de Bioética, 1(1): 163-183.
NRC - National Research Council, (1994). Nutrient Requirements of Poultry. (9th rev. ed.). Washington, DC: National Academy Press.
Rath, N.C., Huff, W.E., Bayyari, G.R. & Balog, J.M. (1998). Cell death in avian tibial dyschondroplasia. Avian Diseases, 42(1): 72–79.
Rath, N.C., Huff, W.E., Balog, J.M. & Huff, G.R. (2004). Comparative efficacy of different dithiocarbamates to induce tibial dyschondroplasia in poultry. Poultry Science, 83(2): 266–274. doi: https://doi.org/10.1093/ps/83.2.266
Rath, N.C., Kannan, L., Pillai, P.B., Huff, W.E., Huff, G.R., Horst, R.L. & Emmert, J.L., (2007). Evaluation of the efficacy of vitamin D3 or its metabolites on thiram-induced tibial dyschondroplasia in chickens. Research in Veterinary Science, 83(2): 244–250. doi: https://doi.org/10.1016/j.rvsc.2006.12.008
Rostagno, H.S., Albino, L.F.T., Donzele, J.L., Gomes, P.C., Oliveira, R.F, Lopes, D.C., ... & Euclides, R.F. (2011). Tabelas brasileiras para aves e suínos: composição de alimentos e exigências nutricionais. (3ra ed.). Viçosa, Brasil: MG, Universidade Federal de Viçosa.
Saif, Y.M., Fadly, A.M., Glisson, J.R., Mcdougald, L.R., Nolan, L.K. & Swayne, D.E. (2008). Diseases of poultry. (12th ed.). Ames, Iowa: Blackwell Publishing.
Takita, T.S., Gonzales, E., Loddi, M.M. & Ramos, A.A. (1998). Métodos de avaliação de discondroplasia tibial em frangos de corte. In: Conferência Apinco de Ciência e Tecnologia Avícola, Anais. Campinas: Facta.
Thorp, B.H., Whitehead, C.C. & Rennie, J.S. (1991). Avian tibial dyschondroplasia: a comparison of the incidence and severity as assessed by gross examination and histopathology. Research in Veterinary Science, 51(1): 48–54. doi: https://doi.org/10.1016/0034-5288(91)90030-R
Thorp, B.H., Ducro, B., Whitehead, C.C., Farquharson, C. & Sorensen, P. (1993). Avian tibial dyschondroplasia: the interaction of genetic selection and dietary 1,25 dihydroxycholecalciferol. Avian Pathology, 22(2): 311–324. doi: https://doi.org/10.1080/03079459308418923
Thorp, B.H. (1994). Skeletal disorders in the fowl: a review. Avian Pathology, 23(2): 203–236. doi: https://doi.org/10.1080/03079459408418991
Thorp, B.H., Dick, L., Jefferies, D., Houston, B. & Wilson, J. (1997). An assessment of the efficacy of the lixiscope for the detection of tibial dyschondroplasia. Avian Pathology, 26(1): 97–104. doi: https://doi.org/10.1080/03079459708419197
Tian, W.X., Li, J.K., Qin, P., Wang, R., Ning, G.B., Qiao, J.G., … & Guo, D.Z. (2013). Screening of differentially expressed genes in the growth plate of broiler chickens with Tibial Dyschondroplasia by microarray analysis. Bio Med Central Genomics, 14(1): 276. doi: https://dx.doi.org/10.1186%2F1471-2164-14-276.
Tselepis, C., Kwan, A.P.L., Thornton, D. & Sheehan, J. (2000). The biochemical characterization of aggrecan from normal and tibialdyschondroplasic chicken growth-plate cartilage. Biochemical Journal, 351(2): 517–525.
Whitehead, C.C. (1995). The role of vitamin D metabolites in the prevention of tibial dyschondroplasia. Animal Feed Science and Technology, 53(2): 205–210. doi: https://doi.org/10.1016/0377-8401(95)02013-P
Whitehead, C.C. (2009). Factores nutricionales que influyen en los problemas óseos actuales de los broilers. Memorias XLVI Simposio científico de avicultura. Zaragoza.
Zhang, J.P., Deng, Y.F., Zhou, Z.L. & Hou, J.F. (2013). Expression and identification of recombinant chicken vascular endothelial growth factor in Pichia pastoris and its role in the pathogenesis of tibial dyschondroplasia. Poultry Science, 92(12): 3214–3227. doi: 10.3382/ps.2013-03420.
Zhang, H., Mehmood, K., Li, K., Rehman, M., Jiang, X., Huang, S., Wang, L., Zhang, L., ... & Li, J. (2018). Icariin ameliorate thiraminduced tibial dyschondroplasia via regulation of WNT4 and VEGF Expression in broiler chickens. Frontiers in Pharmacology, 9(1):123. doi: 10.3389/fphar.2018.00123
Zhang, J., Huang, S., Tong, X., Zhang, L., Jiang, X., Zhang,H., Mehmood, K., & Li, J. (2019). Chlorogenic Acid Alleviates ThiramInduced Tibial Dyschondroplasia by Modulating Caspases, BECN1 Expression and ECM Degradation. International Journal of Molecular Sciences, 20(13):3160. doi: 10.3390/ijms20133160
Edwards, H.M. & Veltmann, J.R. (1983). The role of calcium and phosphorus in the etiology of tibial dyschondroplasia in young chicks. Journal of Nutrition, 113(8): 1568–1575. doi: https://doi.org/10.1093/jn/113.8.1568
Farquharson, C., Loveridge, N., Whitehead, C., Rennie, S., Jakowlew, S. & Thorp, B. (1992). P9. Control of chondrocyte maturation: role of glycosaminoglycans, c-myc and TGFβ in the development of avian tibial dyschondroplasia. Bone, 13(3): 277. doi: https://doi.org/10.1016/8756-3282(92)90228-O
Farquharson, C. & Jefferies, D. (2000). Chondrocytes and Longitudinal Bone Growth: The Development of Tibial Dyschondroplasia. Poultry Science, 79(7): 994–1004. doi: https://doi.org/10.1093/ps/79.7.994
Imik, H., Kapakin, K., Gümüş, R., Kapakin, S. & Kurt, A. (2012). The effect of tibial dyschondroplasia on metabolic parameters in broiler chickens. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 59(1): 271–277. doi: 10.1501/Vetfak_0000002538
Julian, R.J. (1998). Rapid growth problems: ascites and skeletal deformities in broilers. Poultry Science, 77(12): 1773–1780. doi: https://doi.org/10.1093/ps/77.12.1773
Julian, R.J. (2005). Production and growth related disorders and other metabolic diseases of poultry--a review.The Veterinary Journal, 169(3): 350–369. doi: https://doi.org/10.1016/j.tvjl.2004.04.015
Kapakin, K., Kapakin, S., Imik, H., Gumus, R. & Eser, G. (2019). The Investigation of the Relationship Between HSP27 Release and Oxidative DNA Damage in Broiler Chickens with Tibial Dyschondroplasia by Using Histopathological and Immunohistochemical Methods. Brazilian Journal of Poultry, 21(3): 1–6. doi: http://dx.doi.org/10.1590/1806-9061-2019-1091
Mehmood, K., Zhang, H., Li, K., Wang, L., Rehman, M., Nabi, F., …& Li, J. (2018). Effect of tetramethylpyrazine on tibial dyschondroplasia incidence, tibial angiogenesis, performance and characteristics via HIF-1a/VEGF signaling pathway in chickens. Scientific Reports, 8(1):2495. doi: 10.1038/s41598-018-20562-3.
Mrad, A. (2006). Ética en la investigación con modelos animales experimentales. Alternativas y las 3 RS de Russel. Una responsabilidady un compromiso ético que nos compete a todos. Revista Colombiana de Bioética, 1(1): 163-183.
NRC - National Research Council, (1994). Nutrient Requirements of Poultry. (9th rev. ed.). Washington, DC: National Academy Press.
Rath, N.C., Huff, W.E., Bayyari, G.R. & Balog, J.M. (1998). Cell death in avian tibial dyschondroplasia. Avian Diseases, 42(1): 72–79.
Rath, N.C., Huff, W.E., Balog, J.M. & Huff, G.R. (2004). Comparative efficacy of different dithiocarbamates to induce tibial dyschondroplasia in poultry. Poultry Science, 83(2): 266–274. doi: https://doi.org/10.1093/ps/83.2.266
Rath, N.C., Kannan, L., Pillai, P.B., Huff, W.E., Huff, G.R., Horst, R.L. & Emmert, J.L., (2007). Evaluation of the efficacy of vitamin D3 or its metabolites on thiram-induced tibial dyschondroplasia in chickens. Research in Veterinary Science, 83(2): 244–250. doi: https://doi.org/10.1016/j.rvsc.2006.12.008
Rostagno, H.S., Albino, L.F.T., Donzele, J.L., Gomes, P.C., Oliveira, R.F, Lopes, D.C., ... & Euclides, R.F. (2011). Tabelas brasileiras para aves e suínos: composição de alimentos e exigências nutricionais. (3ra ed.). Viçosa, Brasil: MG, Universidade Federal de Viçosa.
Saif, Y.M., Fadly, A.M., Glisson, J.R., Mcdougald, L.R., Nolan, L.K. & Swayne, D.E. (2008). Diseases of poultry. (12th ed.). Ames, Iowa: Blackwell Publishing.
Takita, T.S., Gonzales, E., Loddi, M.M. & Ramos, A.A. (1998). Métodos de avaliação de discondroplasia tibial em frangos de corte. In: Conferência Apinco de Ciência e Tecnologia Avícola, Anais. Campinas: Facta.
Thorp, B.H., Whitehead, C.C. & Rennie, J.S. (1991). Avian tibial dyschondroplasia: a comparison of the incidence and severity as assessed by gross examination and histopathology. Research in Veterinary Science, 51(1): 48–54. doi: https://doi.org/10.1016/0034-5288(91)90030-R
Thorp, B.H., Ducro, B., Whitehead, C.C., Farquharson, C. & Sorensen, P. (1993). Avian tibial dyschondroplasia: the interaction of genetic selection and dietary 1,25 dihydroxycholecalciferol. Avian Pathology, 22(2): 311–324. doi: https://doi.org/10.1080/03079459308418923
Thorp, B.H. (1994). Skeletal disorders in the fowl: a review. Avian Pathology, 23(2): 203–236. doi: https://doi.org/10.1080/03079459408418991
Thorp, B.H., Dick, L., Jefferies, D., Houston, B. & Wilson, J. (1997). An assessment of the efficacy of the lixiscope for the detection of tibial dyschondroplasia. Avian Pathology, 26(1): 97–104. doi: https://doi.org/10.1080/03079459708419197
Tian, W.X., Li, J.K., Qin, P., Wang, R., Ning, G.B., Qiao, J.G., … & Guo, D.Z. (2013). Screening of differentially expressed genes in the growth plate of broiler chickens with Tibial Dyschondroplasia by microarray analysis. Bio Med Central Genomics, 14(1): 276. doi: https://dx.doi.org/10.1186%2F1471-2164-14-276.
Tselepis, C., Kwan, A.P.L., Thornton, D. & Sheehan, J. (2000). The biochemical characterization of aggrecan from normal and tibialdyschondroplasic chicken growth-plate cartilage. Biochemical Journal, 351(2): 517–525.
Whitehead, C.C. (1995). The role of vitamin D metabolites in the prevention of tibial dyschondroplasia. Animal Feed Science and Technology, 53(2): 205–210. doi: https://doi.org/10.1016/0377-8401(95)02013-P
Whitehead, C.C. (2009). Factores nutricionales que influyen en los problemas óseos actuales de los broilers. Memorias XLVI Simposio científico de avicultura. Zaragoza.
Zhang, J.P., Deng, Y.F., Zhou, Z.L. & Hou, J.F. (2013). Expression and identification of recombinant chicken vascular endothelial growth factor in Pichia pastoris and its role in the pathogenesis of tibial dyschondroplasia. Poultry Science, 92(12): 3214–3227. doi: 10.3382/ps.2013-03420.
Zhang, H., Mehmood, K., Li, K., Rehman, M., Jiang, X., Huang, S., Wang, L., Zhang, L., ... & Li, J. (2018). Icariin ameliorate thiraminduced tibial dyschondroplasia via regulation of WNT4 and VEGF Expression in broiler chickens. Frontiers in Pharmacology, 9(1):123. doi: 10.3389/fphar.2018.00123
Zhang, J., Huang, S., Tong, X., Zhang, L., Jiang, X., Zhang,H., Mehmood, K., & Li, J. (2019). Chlorogenic Acid Alleviates ThiramInduced Tibial Dyschondroplasia by Modulating Caspases, BECN1 Expression and ECM Degradation. International Journal of Molecular Sciences, 20(13):3160. doi: 10.3390/ijms20133160
