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Publication Date: 2008-06-20
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Uribe Velásquez, L. F. ., Lenz Souza, M. I. ., & Henry Osorio, J. . (2008). Origin and characteristics of preovulatory follicles after induced luteolysis at different stages of the luteal phase of the oestrous cycle in ewes. Revista Veterinaria Y Zootecnia (On Line), 2(1), 32–41. Retrieved from https://revistasojs.ucaldas.edu.co/index.php/vetzootec/article/view/5744
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Abstract
ABSTRACT: The purpose of this study was to evaluate ovarian response, using transrectal ovarian ultrasonography, after two injections of Prostaglandin F2α (PGF2α) given at different intervals. Fourteen Bergamasca ewes were examined during the breeding season, and they were injected with an intramuscular dose of a PGF2α analogue. Ewes were randomly allocated to two groups (n = 7) which received PGF2α for 7 days (PG7) or 9 days (PG9) after ovulation (when the dominant follicle of wave 2 was expected to be in the growing and plateau phase, respectively). The ovaries were examined daily with transrectal ultrasonography Aloka 500® with 7.5 MHz linear array transducer, which started 1day prior to the second PG injection and ended 10 days after ovulation in both groups. Jugular vein blood samples were collected daily for progesterone assay. Plasma P4 concentration were lower in PG7 that in PG9 immediately before the PGF2α treatment (4.10±0.17 vs 4.91±0.29 ng/mL, respectively; P<0.05). Mean maximum diameter size attained by the dominant follicle of wave 2 tended to be larger in the PG7 group, compared with PG9 (5.5±0.19 vs 4.29±0.26 mm; P<0.05). The number of small follicles (2-2.5 mm) was greater (4.57±0.78 vs 8.42±1.36) at day 6, for PG7 and PG9, respectively, whereas no changes were observed in medium follicles. The proportion of large follicles (4 mm) increased after luteolysis. Values were lower for ewes treated with PG7, whereas values were more stable over time for ewes treated with PG9. In conclusion, ewes with rapid and complete luteal regression, ovulation occurred from the dominant follicle of wave 2 when the females were treated on days 7 and 9.
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References
Ali, A. Effect of time of eCG administration on follicular response and reproductive performance of FGA-treated Ossimi ewes. Small Ruminant Research, v.72, p.33-37, 2007.
Amorim, E.A.M.; Torres, C.A.A.; Amorim, L.S. et al. Dinâmica follicular em cabras da raca Toggenburg em lactação tratadas ou não com somatotropina bovina recombinante. Arquivos Brasileiros de Medicina Veterinária e Zootecnia, v.59, p.1500- 1508, 2007.
Binelli, M.; Hampton, J.; Buhi, W.C. et al. Persistent dominant follicle alters pattern of oviductal secretory proteins from cows at estrus. Biology of Reproduction, v.61, p.127-134, 1999.
Campbell, B.K.; Mann, G.E.; McNeilly, A.S. et al. Pulsatile secretion of inhibin, oestradiol and androstenedione by the ovary of the sheep during the oestrus cycle. Journal Endocrinology, v.126, p.385-393, 1990.
Castonguay, F.; Dufour, J.J.; Minvielle, F. et al. Follicular dynamics and dominance in Boorola x Finnish Landrace and Boorola x Suffolk ewes heterozygous for the F gene. Journal Reproduction and Fertility, v.89, p.193-203, 1990.
Evans, A.C.; Flynn, J.D.; Quinn, K.M. et al. Ovulation of aged follicles does not affect embryo quality or fertility after a 14-day progestagen estrus synchronization protocol in ewes. Theriogenology, v.56, p.923-936, 2001.
Fabre, S.; Pierre, A.; Mulsant, P. et al. Regulation of ovulation rate in mammals: contribution of sheep genetic models. Reproductive Biology and Endocrinology, v.4, p.1-12, 2006.
GdeNicolo, S.T.; Morris, S.T.; Kenyon, P.R. et al. Induced seasonal reproductive performance in two breeds of sheep. Animal Reproduction Science, v.103, p.278-289, 2007.
Ginther, O.J.; Araujo, R.R.; Palhao, M.P. et al. Necessity of sequencial pulses of prostaglandin F2alpha for complete physiologic leteolysis in cattle. Biology of Reprouction, v.80, p.641-648, 2009.
Goel, A.K.; Agrawal, K.P. Oestrus synchronization in cyclic goats following lutalyse administration. Indian Journal of Animal Science, v.68, p.155- 156, 1998.
González de Bulnes, A.; Moreno, S.; Gómez-Brunet, A. et al. Follicular dynamic during the oestrous cycle in dairy goats. Animal Science, v.68, p.547- 554, 1999.
González de Bulnes, A.; Veiga-López, A.; García, P. et al. Effects of progestagens and prostaglandin analogues on ovarían function and embryo viability in sheep. Theriogenology, v.63, p.2523- 2534, 2005.
González-Añover, P.; Encinas, T.; Veiga-López, A. et al. Effects of bree don folicular dynamics and oestradiol secretion during the folicular phase in sheep. Reproduction Domestic Animal, v.42, p.29-33, 2007.
Goravanahally, M.P.; Sen, A.; Inskeep, E.K., et al. PKCepsilon and an increase in intracellular calcium concentration are necessary for PGF2alpha to inhibit LH-stimulated progesterone secretion in cultured bovine steroidogenic luteal cells. Reproductive Biology and Endocrinology, v.5, p.1-13, 2007.
Guido, S.I.; Oliveira, M.A L.; Lima, P.F. Eficiência do syncromate-B associado a P F2 sobre o restablecimento da ciclicidade de cabras Saanen em anestro lactacional. Revista Brasileira de Reproducción Animal, v.23, p.51-56, 1999.
Hackett, A.J.; Robertson, H.A. Effect of dose and time of injection of prostaglandin F 2α in cycling ewes. Theriogenology, v. 13, p.347-351, 1980.
Herrera, H.L.; Feldman, S.D.; Zarco, Q.L. et al. Evaluación del efecto luteolítico de la prostaglandina F2 alfa en diferentes días del ciclo estral de la borrega. Veterinaria México, v. 21, p.143-147, 1990.
Holtz, W.; Sohnrey, B.; Gerland, M., et al. Ovsynch synchronization and fixed-time insemination in goats. Theriogenology, v. 69, p.785-792, 2008.
Kridli, R.T.; Al-Khetlib, S.S. Reproductive responses in ewes treated with eCG or increasing doses of royal jelly. Animal Reproduction Science, v.92, p.75-85, 2006.
Lafrance, M.; Goff, A. K. Effect of pregnancy on oxytocin-induced release of prostaglandin F2a in heifers. Biology of Reproduction, v.3, p.1113– 1119, 1985.
Latour, D.; Littell, R. Advanced general linear models with an emphasis on mixed models. Version 6.12. Cary: SAS Institute, 1996. 268p.
Leyva, V.; Buckrell, B.C.; WALTON, J.S. Regulation of follicular and ovulation in ewes by exogenous progestagen. Theriogenology, v.50, p.395-416, 1998.
Liu, X.; Dai, Q.; Hart, E.J. et al. Ultrasonographic characteristics of ovulatory follicles and associated endocrine changes in cyclic ewes treated with medroxyprogesterone acetate (MAP)-releasing intravaginal sponges and equine chorionic gonadotrophin (eCG). Reproduction Domestic Animals, v.42, p.393-401, 2007.
López-Sebastian, A.; González-Bulnes, A.; Carrizosa, J.A. et al. New estrus synchronization and artificial insemination protocol for goats based on male exposure, progesterone and cloprostenol during the non-breeding season. Theriogenology, v.68, p.1081-1087, 2007.
Lucy, M.C.; Savio, J.D.; Badinga, L. et al. Factors that affect ovarian follicular dynamics in cattle. Journal of Animal Science, v.70, p.3615-3626, 1992.
McGinley, R.; Casey, J. H. Analysis of progesterone in unextrated serum; a method using danazol (17 a-preg-4-en-20-yno (2,3) isoxasol-17-ol) a bloker of steroid binding to proteins. Steroids, v.33, p.127-138, 1979.
McNeilly, A.S.; Picton, H.M.; Campbell, B.K. et al. Gonadotrofic control of follicle growth in the ewe. Journal of Reproduction and Fertility, v.43, p.177-186, 1991.
Menchaca, A.& Rubianes, E. Efecto of high progesterone concentrations during the early luteal phase in the lenght of the ovulatory cycle of gotas. Animal Reproduction Science, v.68, p.69-76, 2001.
Menchaca, A. & Rubianes, E. Relation between progesterone concentrations during the early luteal phase and follicular dynamic in goats. Theriogenology, v.57, p.1411-1419, 2002.
Menchaca, A.; Miller, V.; Salveraglio, V. et al. Endocrine, luteal and folicular responses after the use of the short-term protocol to synchronize ovulation in goats. Animal Reproduction Science, v.102, p.76-87, 2007.
Mihm, M.; Curran, N.; Hyttel, P. et al. Effect of dominant follicle persistence on follicular fluid estradiol and inhibin and on oocyte maturation in heifers. Journal of Reproduction and Fertility, v.116, p.293-304, 1999.
Pierson, R.A.; Ginther, J.O. Follicular population during the oestrous cycle in heifers. I – Influence of day. Animal Reproduction Science, v.14, p.165-176, 1987.
Quirk, S.M.; Quirk, G.J.; Hickey, J.E. et al. Growth and regression of ovarian follicles during the follicular phase of the oestrous cycle in heifers undergoing spontaneous and PGF2α induced luteolysis. Journal Reproduction of Fertility, v.77, p.211-219, 1986.
Ravindra, J.P.; Rawlings, N.C.; Evans, A.C.O. et al. Ultrasonographic study of ovarian follicular dynamics in ewes during the estrous cycle. Journal Reproduction and Fertility, v.101, p.501-509, 1994.
Safdarian, M.; Kafi, M.; Hashemi, M. Reproductive performance of Karakul ewes following different oestrous synchronization treatments outside the natural breeding season. South African Journal of Animal Sciences, v.36, p.229-234, 2006.
Scaramuzzi, R.J.; Adams, N.R.; Baird, D.T. et al. A model for follicle selection and the determination of ovulation rate in the ewe. Reproduction Fertility Development, v.5, p.459-478, 1993.
Schrick, F.N.; Surface, R.A.; Pritchard, J.Y. et al. Ovarian structures during the estrous cycle and early pregnancy in ewes. Biology of Reproduction, v.49, p.1133-1140, 1993.
Uribe-Velásquez, L.F.; Oba, E.; Lara-Herrera, L.C.; et al. Respostas endócrinas e ovarianas associadas com o folículo dominante da primeira onda folicular em ovelhas sincronizadas com CIDR ou PGF2α. Revista Brasileira de Zootecnia, v.31, p.944-953, 2002.
Uribe-Velásquez, L.F.; Souza, M.I.L.; Loaiza, A.M.E. Efecto de la sincronización del estro con prostaglandina-f2α vs CIDR + 500 UI de eCG en ovejas Bergamacia durante el inicio de la fase luteal. Revista Científica, v.XVIII, p.368-373, 2008a.
Uribe-Velásquez, L.F.; Oba, E.; Souza, M.I.L. Población folicular y concentraciones plasmáticas de progesterona (P4) en ovejas sometidas a diferentes protocolos de sincronización. Archivos de Medicina Veterinaria, v.40, p.83-88, 2008b.
Uribe-Velásquez, L.F.; Oba, E.; Souza, M.I.L. Efeitos da progesterona exógena sobre o desenvolvimento folicular em ovelhas. Arquivos Brasileiros de Medicina Veterinária e Zootecnia, v.60, p.58- 65, 2008c.
Weems, C.W.; Weems, Y.S.; Randel, R.D. Prostaglandins and reproduction in female farm animals. The Veterinary Journal, v. 171, p.206- 228, 2006.
Amorim, E.A.M.; Torres, C.A.A.; Amorim, L.S. et al. Dinâmica follicular em cabras da raca Toggenburg em lactação tratadas ou não com somatotropina bovina recombinante. Arquivos Brasileiros de Medicina Veterinária e Zootecnia, v.59, p.1500- 1508, 2007.
Binelli, M.; Hampton, J.; Buhi, W.C. et al. Persistent dominant follicle alters pattern of oviductal secretory proteins from cows at estrus. Biology of Reproduction, v.61, p.127-134, 1999.
Campbell, B.K.; Mann, G.E.; McNeilly, A.S. et al. Pulsatile secretion of inhibin, oestradiol and androstenedione by the ovary of the sheep during the oestrus cycle. Journal Endocrinology, v.126, p.385-393, 1990.
Castonguay, F.; Dufour, J.J.; Minvielle, F. et al. Follicular dynamics and dominance in Boorola x Finnish Landrace and Boorola x Suffolk ewes heterozygous for the F gene. Journal Reproduction and Fertility, v.89, p.193-203, 1990.
Evans, A.C.; Flynn, J.D.; Quinn, K.M. et al. Ovulation of aged follicles does not affect embryo quality or fertility after a 14-day progestagen estrus synchronization protocol in ewes. Theriogenology, v.56, p.923-936, 2001.
Fabre, S.; Pierre, A.; Mulsant, P. et al. Regulation of ovulation rate in mammals: contribution of sheep genetic models. Reproductive Biology and Endocrinology, v.4, p.1-12, 2006.
GdeNicolo, S.T.; Morris, S.T.; Kenyon, P.R. et al. Induced seasonal reproductive performance in two breeds of sheep. Animal Reproduction Science, v.103, p.278-289, 2007.
Ginther, O.J.; Araujo, R.R.; Palhao, M.P. et al. Necessity of sequencial pulses of prostaglandin F2alpha for complete physiologic leteolysis in cattle. Biology of Reprouction, v.80, p.641-648, 2009.
Goel, A.K.; Agrawal, K.P. Oestrus synchronization in cyclic goats following lutalyse administration. Indian Journal of Animal Science, v.68, p.155- 156, 1998.
González de Bulnes, A.; Moreno, S.; Gómez-Brunet, A. et al. Follicular dynamic during the oestrous cycle in dairy goats. Animal Science, v.68, p.547- 554, 1999.
González de Bulnes, A.; Veiga-López, A.; García, P. et al. Effects of progestagens and prostaglandin analogues on ovarían function and embryo viability in sheep. Theriogenology, v.63, p.2523- 2534, 2005.
González-Añover, P.; Encinas, T.; Veiga-López, A. et al. Effects of bree don folicular dynamics and oestradiol secretion during the folicular phase in sheep. Reproduction Domestic Animal, v.42, p.29-33, 2007.
Goravanahally, M.P.; Sen, A.; Inskeep, E.K., et al. PKCepsilon and an increase in intracellular calcium concentration are necessary for PGF2alpha to inhibit LH-stimulated progesterone secretion in cultured bovine steroidogenic luteal cells. Reproductive Biology and Endocrinology, v.5, p.1-13, 2007.
Guido, S.I.; Oliveira, M.A L.; Lima, P.F. Eficiência do syncromate-B associado a P F2 sobre o restablecimento da ciclicidade de cabras Saanen em anestro lactacional. Revista Brasileira de Reproducción Animal, v.23, p.51-56, 1999.
Hackett, A.J.; Robertson, H.A. Effect of dose and time of injection of prostaglandin F 2α in cycling ewes. Theriogenology, v. 13, p.347-351, 1980.
Herrera, H.L.; Feldman, S.D.; Zarco, Q.L. et al. Evaluación del efecto luteolítico de la prostaglandina F2 alfa en diferentes días del ciclo estral de la borrega. Veterinaria México, v. 21, p.143-147, 1990.
Holtz, W.; Sohnrey, B.; Gerland, M., et al. Ovsynch synchronization and fixed-time insemination in goats. Theriogenology, v. 69, p.785-792, 2008.
Kridli, R.T.; Al-Khetlib, S.S. Reproductive responses in ewes treated with eCG or increasing doses of royal jelly. Animal Reproduction Science, v.92, p.75-85, 2006.
Lafrance, M.; Goff, A. K. Effect of pregnancy on oxytocin-induced release of prostaglandin F2a in heifers. Biology of Reproduction, v.3, p.1113– 1119, 1985.
Latour, D.; Littell, R. Advanced general linear models with an emphasis on mixed models. Version 6.12. Cary: SAS Institute, 1996. 268p.
Leyva, V.; Buckrell, B.C.; WALTON, J.S. Regulation of follicular and ovulation in ewes by exogenous progestagen. Theriogenology, v.50, p.395-416, 1998.
Liu, X.; Dai, Q.; Hart, E.J. et al. Ultrasonographic characteristics of ovulatory follicles and associated endocrine changes in cyclic ewes treated with medroxyprogesterone acetate (MAP)-releasing intravaginal sponges and equine chorionic gonadotrophin (eCG). Reproduction Domestic Animals, v.42, p.393-401, 2007.
López-Sebastian, A.; González-Bulnes, A.; Carrizosa, J.A. et al. New estrus synchronization and artificial insemination protocol for goats based on male exposure, progesterone and cloprostenol during the non-breeding season. Theriogenology, v.68, p.1081-1087, 2007.
Lucy, M.C.; Savio, J.D.; Badinga, L. et al. Factors that affect ovarian follicular dynamics in cattle. Journal of Animal Science, v.70, p.3615-3626, 1992.
McGinley, R.; Casey, J. H. Analysis of progesterone in unextrated serum; a method using danazol (17 a-preg-4-en-20-yno (2,3) isoxasol-17-ol) a bloker of steroid binding to proteins. Steroids, v.33, p.127-138, 1979.
McNeilly, A.S.; Picton, H.M.; Campbell, B.K. et al. Gonadotrofic control of follicle growth in the ewe. Journal of Reproduction and Fertility, v.43, p.177-186, 1991.
Menchaca, A.& Rubianes, E. Efecto of high progesterone concentrations during the early luteal phase in the lenght of the ovulatory cycle of gotas. Animal Reproduction Science, v.68, p.69-76, 2001.
Menchaca, A. & Rubianes, E. Relation between progesterone concentrations during the early luteal phase and follicular dynamic in goats. Theriogenology, v.57, p.1411-1419, 2002.
Menchaca, A.; Miller, V.; Salveraglio, V. et al. Endocrine, luteal and folicular responses after the use of the short-term protocol to synchronize ovulation in goats. Animal Reproduction Science, v.102, p.76-87, 2007.
Mihm, M.; Curran, N.; Hyttel, P. et al. Effect of dominant follicle persistence on follicular fluid estradiol and inhibin and on oocyte maturation in heifers. Journal of Reproduction and Fertility, v.116, p.293-304, 1999.
Pierson, R.A.; Ginther, J.O. Follicular population during the oestrous cycle in heifers. I – Influence of day. Animal Reproduction Science, v.14, p.165-176, 1987.
Quirk, S.M.; Quirk, G.J.; Hickey, J.E. et al. Growth and regression of ovarian follicles during the follicular phase of the oestrous cycle in heifers undergoing spontaneous and PGF2α induced luteolysis. Journal Reproduction of Fertility, v.77, p.211-219, 1986.
Ravindra, J.P.; Rawlings, N.C.; Evans, A.C.O. et al. Ultrasonographic study of ovarian follicular dynamics in ewes during the estrous cycle. Journal Reproduction and Fertility, v.101, p.501-509, 1994.
Safdarian, M.; Kafi, M.; Hashemi, M. Reproductive performance of Karakul ewes following different oestrous synchronization treatments outside the natural breeding season. South African Journal of Animal Sciences, v.36, p.229-234, 2006.
Scaramuzzi, R.J.; Adams, N.R.; Baird, D.T. et al. A model for follicle selection and the determination of ovulation rate in the ewe. Reproduction Fertility Development, v.5, p.459-478, 1993.
Schrick, F.N.; Surface, R.A.; Pritchard, J.Y. et al. Ovarian structures during the estrous cycle and early pregnancy in ewes. Biology of Reproduction, v.49, p.1133-1140, 1993.
Uribe-Velásquez, L.F.; Oba, E.; Lara-Herrera, L.C.; et al. Respostas endócrinas e ovarianas associadas com o folículo dominante da primeira onda folicular em ovelhas sincronizadas com CIDR ou PGF2α. Revista Brasileira de Zootecnia, v.31, p.944-953, 2002.
Uribe-Velásquez, L.F.; Souza, M.I.L.; Loaiza, A.M.E. Efecto de la sincronización del estro con prostaglandina-f2α vs CIDR + 500 UI de eCG en ovejas Bergamacia durante el inicio de la fase luteal. Revista Científica, v.XVIII, p.368-373, 2008a.
Uribe-Velásquez, L.F.; Oba, E.; Souza, M.I.L. Población folicular y concentraciones plasmáticas de progesterona (P4) en ovejas sometidas a diferentes protocolos de sincronización. Archivos de Medicina Veterinaria, v.40, p.83-88, 2008b.
Uribe-Velásquez, L.F.; Oba, E.; Souza, M.I.L. Efeitos da progesterona exógena sobre o desenvolvimento folicular em ovelhas. Arquivos Brasileiros de Medicina Veterinária e Zootecnia, v.60, p.58- 65, 2008c.
Weems, C.W.; Weems, Y.S.; Randel, R.D. Prostaglandins and reproduction in female farm animals. The Veterinary Journal, v. 171, p.206- 228, 2006.
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