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Publication Date: 2012-06-15
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Urrea Chávez , . A. M. . (2012). Regenerative medicine with platelet rich plasma: a therapy for tendonitis in equines. Revista Veterinaria Y Zootecnia (On Line), 6(1), 79–86. Retrieved from https://revistasojs.ucaldas.edu.co/index.php/vetzootec/article/view/4449
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Abstract
ABSTRACT: Tendonitis is considered one of the most frequent conditions which affect the soft tissues. This condition may appear in horses of any kind of the equestrian discipline, resulting in significant economic loss for the equine industry. Nowadays, a variety of medical techniques area available to correct tendon injuries but, in spite of the multiple treatments that have been proposed, they have not obtained a full functionality. Within this context, regenerative medicine offers the perspective of repairing the structure and normal or almost normal function of the injured tendon, resulting in the satisfactory reestablishment of the activity without the risk of reinjuring. Recently, the use of platelet-rich plasma (PRP) has been considered as therapy for tendonitis in equines, due to its nature, its apparent biological effect and its low local reaction. All of these beneficial effects make of this treatment one of the most studied in these past years. This bibliographical compilation summarizes the advantages and disadvantages of PRP treatment as well as the techniques presently proposed for its attainment and application method for the treatment of tendonitis in equines.
References
Anitua, E.; Andia I.; Ardanza B. et al. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb and Haemost, v.91, n.1, p.4-15, 2004.
Arguelles D.; Carmona J.U.; Pastor J. et al. Evaluation of single and double centrifugation tube methods for concentrating equine platelets. Research in Vet Science, v.81, p.237-245, 2006.
Alves, A.G.L.; Stewart, A.A.; Dudhia, J. et al. Cellbased Therapies for Tendon and Ligament Injuries. Vet Clin Equine, v.27, p.315-333, 2011.
Abellanet de Oleza, I. La terapia de lesiones de tejidos blandos y articulaciones con plasma rico en plaquetas en caballos de deporte: evidencias clínicas y bioquímicas que validan su utilización. Barcelona: Departament de medicina i cirugía animals, Facultad de veterinaria, Universitat Autónoma de Barcelona, 2009. Phd Thesis.
Balesdent, B.A.P; García, A.A.L; Mere, E.S. et al. Autologous implant of Bone Marrow Mononuclear Cells as Treatment of Induced Equine Tendinitis. Intern J Appl Res Vet Med, v.6, n.1, p.46-54, 2008.
Bordignon, C.; Carlo, S.C.; Colombo, M.P. et al. Cell therapy: achievements and perspectives. Haematologica, v.84, p.1110-1149, 1999. Carmona, J.U.; Argüelles, D.; Climent, F. et al. Report of the intraarticular treatment with platelet rich plasma in 7 horses with joint disease. Proceedings of the 14th Annual Scientific Meeting of European College Veterinary Surgery, 2005. p.68-71.
Carmona, J.U., Argüelles, D.; Climent, F. et al. Autologous platelet concentrates as a treatment of horses with osteoarthritis: a preliminary pilot clinical study. J. Equine Vet. Sci., v.27, n.4, p.167-170, 2007.
Carmona, J.U.; López, C.; Prades, M. Uso de concentrados autólogos de plaquetas obtenidos mediante el método del tubo como tratamiento de artropatías en caballos. Arch. Med. Vet., v.41, n.2, p.175-179, 2009a.
Carmona, J.U.; Prades M.; Argüelles D. Concentrados autólogos de plaquetas como tratamiento de lesiones de tejidos blandos del aparato locomotor en caballos. Arch. Med. Vet., v.41, p.77-82, 2009b.
Dyson, S.J. Treatment of superficial digital flexor tendinitis: a comparison of conservative management, sodium hyaluronate, and glycosaminoglycan polysulfate. Proceeding of the Annual Convention of the AAEP, v.43, p.297-300, 1997.
Eppley, L.B.; Pietrzak, S.W.; Blanton, M. Platelet-Rich Plasma: A Review of Biology and Applications in Plastic Surgery. Plastic Reconstruction Surgery, v.118, n.6, p.147e-159e, 2006.
Fortier, A.L. Medical therapies for tendonitis. International Congress of World Equine Veterinary Association, Guarujá, Brazil, 2009. Fortier, A.L.; Smith, K.W.R. Regenerative Medicine for Tendinous and Ligamentous Injuries of Sport Horses. Vet Clin Equine, v.24, p.191- 201, 2008.
Genovese, R.L.; Reef, V.B.; Longo, K.L. et al. Superficial digital flexor tendonitis: Long term sonographic and clinical study of racehorses. In: Rantanen, N.W.; Hauser, M.L. Proceedings of the Dubai International Equine Symposium (pp.187-205), 1996.
Haynesworth, S.E; Kadiyala, S; Li-Nuo, L. et al. Chemotactic and mitogenic stimulation of human mesenchymal stem cells by platelet rich plasma suggests a mechanism for enhancement of bone repair. Poster presented at: 48th Annual Meeting of the Orthopedic Research Society, 2002, New Orleans.
Ionita, J.C.; Kissich, C.; Böttcher, P. et al. Biochemical characteristics of the equine autologous conditioned plasma (ACP™). Proceedings of the 15th ESVOT congress 2010, Bologna, Italy.
telet-Rich Plasma in the treatment of induced Tendinopathy in horse: histologic evaluation. J. of Equi Vet Science, v.29, n.8, p.618-626, 2009.
Manzano, F.A.; Varela del Arco, M.; Llorente, I.S. Factores de crecimiento plaquetarios en el tratamiento de la tendinitis del tendón flexor digital superficial de un caballo de carreras. Rccv, v.3, n.2, p.1988-2688, 2009.
Mendoza, L.L.; Rojas, L.; Suaste, L.S. et al. Aféresis plaquetaria. Revista Mexicana de Enfermería Cardiológica, v.15, n.3, p.89-93, 2007.
Murphy, S. Platelets from pooled buffy coats: an update. Transfusion, v.45, n.4, p.634-639, 2005.
Pimenta R. de Padua F.F. et al., Treatment of tendinitis in Polo Ponies Using Platelet Rich Plasma (PRP): Case report; Proceedings of the 11th International Congress of World Equine Veterinary Association 2009; Guarujá SP, Brazil.
Rindermann, G.; Cislakova, M.; Arndt, G. et al. Autologous conditioned plasma as therapy of tendon and ligament lesions in seven horses. J. Vet. Sci., v.11, n.2, p.173-175, 2010.
Schnabel, L.V; Lynch, E.M.; Van der Meulen, C.H. et al. Mesenchymal Stem Cells and InsulinLike Growth Factor-I Gene- Enhanced Mesenchymal Stem Cells Improve Structural Aspects of Healing in Equine Flexor Digitorum Superficialis Tendons. J Orthop Res., v.27, p.1392-1398, 2009.
Schnabel, L.V.; Mohammed, H.O.; Miller, B.J. et al. Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res., v.25, p.230-240, 2007.
Schwartz, A.; Martínez, S.G. Factores de crecimiento derivados de plaquetas y sus aplicaciones en medicina regenerativa. Potencialidades del uso del ozono como activador. Revista Española de Ozonoterapia, v.1, n.1, p.54-73, 2011.
Skjong, C.C.; Meininger, A.K.; Sherwin, S.W. Tendinopathy Treatment: Where is the Evidence. Clin Sports Med, v.31, p.329-350, 2012.
Soleimany, F.A. Platelet activation of platelet concentrates derived from buffy coat and apheresis methods. Transfusion and Apheresis Science, v.44, n.1, p.11-13, 2011.
Sporn, M.; Roberts, A. The multifunctional nature of peptide growth factors. In: Sporn, M.; Roberts, A. (Eds.). Peptide growth factors and their receptors 1 (pp. 3-15). 1st ed., 1990.
Sudman, A.E.; Cole, J.B.; Fortier, A.L. Growth factor and catabolic cytokine Are influenced by the cellular composition of Patelets-Rich-Plasma. The American Journal of Sports Medicine, v.39, n.10, p.2135-2140, 2011.
Sutter, W. PRP: Platelet Rich Plasma. Article, p.1-8, 2007 b.
Sutter, W.W. Autologous Cell-Based Therapy for Tendon and Ligament Injuries. Clinical techniques in equine practice, v.6, p.198-208, 2007a
Sutter, W.W.; Kaneps, A.J.; Bertone, A.L. Comparison of hematologic values and transforming growth factor-b and insulin-like growth factor concentrations in platelet concentrates obtained by use of buffy coat and apheresis methods from equine blood. American Journal of Veterinary Research, v.65, p.924-930, 2004.
Textor, J. Autologous Biologic Treatment for Equine Musculoskeletal Injuries: Platelet-Rich Plasma and IL-1 Receptor Antagonist Protein. Vet Clin Equine, v.27, p.275-298, 2011.
Textor, J.A.; Norris, J.W.; Tablin, F. Effects of preparation method, shear force, and exposure to collagen on release of growth factors from equine platelet-rich plasma. Am J. Vet. Res., v.72, n.2, p.271-278, 2011.
Vendruscolo, C.P.; De M. Carvalho, A.; Moraes, L.F. et al. Avaliação da eficácia de diferentes protocolos de preparo do Plasma Rico em Plaquetas para uso em Medicina Equina1. Pesq. Vet. Bras., v.32, n.2, p.106-110, 2012.
Wallis, T.W.; Baxter, M.G.; Werpy, M.N. et al. Acellular Urinary Bladder Matrix in a Collagenase Model of Superficial Digital Flexor Tendonitis In Horses. Original research, v.30, n.7, p.365- 370, 2010.
Arguelles D.; Carmona J.U.; Pastor J. et al. Evaluation of single and double centrifugation tube methods for concentrating equine platelets. Research in Vet Science, v.81, p.237-245, 2006.
Alves, A.G.L.; Stewart, A.A.; Dudhia, J. et al. Cellbased Therapies for Tendon and Ligament Injuries. Vet Clin Equine, v.27, p.315-333, 2011.
Abellanet de Oleza, I. La terapia de lesiones de tejidos blandos y articulaciones con plasma rico en plaquetas en caballos de deporte: evidencias clínicas y bioquímicas que validan su utilización. Barcelona: Departament de medicina i cirugía animals, Facultad de veterinaria, Universitat Autónoma de Barcelona, 2009. Phd Thesis.
Balesdent, B.A.P; García, A.A.L; Mere, E.S. et al. Autologous implant of Bone Marrow Mononuclear Cells as Treatment of Induced Equine Tendinitis. Intern J Appl Res Vet Med, v.6, n.1, p.46-54, 2008.
Bordignon, C.; Carlo, S.C.; Colombo, M.P. et al. Cell therapy: achievements and perspectives. Haematologica, v.84, p.1110-1149, 1999. Carmona, J.U.; Argüelles, D.; Climent, F. et al. Report of the intraarticular treatment with platelet rich plasma in 7 horses with joint disease. Proceedings of the 14th Annual Scientific Meeting of European College Veterinary Surgery, 2005. p.68-71.
Carmona, J.U., Argüelles, D.; Climent, F. et al. Autologous platelet concentrates as a treatment of horses with osteoarthritis: a preliminary pilot clinical study. J. Equine Vet. Sci., v.27, n.4, p.167-170, 2007.
Carmona, J.U.; López, C.; Prades, M. Uso de concentrados autólogos de plaquetas obtenidos mediante el método del tubo como tratamiento de artropatías en caballos. Arch. Med. Vet., v.41, n.2, p.175-179, 2009a.
Carmona, J.U.; Prades M.; Argüelles D. Concentrados autólogos de plaquetas como tratamiento de lesiones de tejidos blandos del aparato locomotor en caballos. Arch. Med. Vet., v.41, p.77-82, 2009b.
Dyson, S.J. Treatment of superficial digital flexor tendinitis: a comparison of conservative management, sodium hyaluronate, and glycosaminoglycan polysulfate. Proceeding of the Annual Convention of the AAEP, v.43, p.297-300, 1997.
Eppley, L.B.; Pietrzak, S.W.; Blanton, M. Platelet-Rich Plasma: A Review of Biology and Applications in Plastic Surgery. Plastic Reconstruction Surgery, v.118, n.6, p.147e-159e, 2006.
Fortier, A.L. Medical therapies for tendonitis. International Congress of World Equine Veterinary Association, Guarujá, Brazil, 2009. Fortier, A.L.; Smith, K.W.R. Regenerative Medicine for Tendinous and Ligamentous Injuries of Sport Horses. Vet Clin Equine, v.24, p.191- 201, 2008.
Genovese, R.L.; Reef, V.B.; Longo, K.L. et al. Superficial digital flexor tendonitis: Long term sonographic and clinical study of racehorses. In: Rantanen, N.W.; Hauser, M.L. Proceedings of the Dubai International Equine Symposium (pp.187-205), 1996.
Haynesworth, S.E; Kadiyala, S; Li-Nuo, L. et al. Chemotactic and mitogenic stimulation of human mesenchymal stem cells by platelet rich plasma suggests a mechanism for enhancement of bone repair. Poster presented at: 48th Annual Meeting of the Orthopedic Research Society, 2002, New Orleans.
Ionita, J.C.; Kissich, C.; Böttcher, P. et al. Biochemical characteristics of the equine autologous conditioned plasma (ACP™). Proceedings of the 15th ESVOT congress 2010, Bologna, Italy.
telet-Rich Plasma in the treatment of induced Tendinopathy in horse: histologic evaluation. J. of Equi Vet Science, v.29, n.8, p.618-626, 2009.
Manzano, F.A.; Varela del Arco, M.; Llorente, I.S. Factores de crecimiento plaquetarios en el tratamiento de la tendinitis del tendón flexor digital superficial de un caballo de carreras. Rccv, v.3, n.2, p.1988-2688, 2009.
Mendoza, L.L.; Rojas, L.; Suaste, L.S. et al. Aféresis plaquetaria. Revista Mexicana de Enfermería Cardiológica, v.15, n.3, p.89-93, 2007.
Murphy, S. Platelets from pooled buffy coats: an update. Transfusion, v.45, n.4, p.634-639, 2005.
Pimenta R. de Padua F.F. et al., Treatment of tendinitis in Polo Ponies Using Platelet Rich Plasma (PRP): Case report; Proceedings of the 11th International Congress of World Equine Veterinary Association 2009; Guarujá SP, Brazil.
Rindermann, G.; Cislakova, M.; Arndt, G. et al. Autologous conditioned plasma as therapy of tendon and ligament lesions in seven horses. J. Vet. Sci., v.11, n.2, p.173-175, 2010.
Schnabel, L.V; Lynch, E.M.; Van der Meulen, C.H. et al. Mesenchymal Stem Cells and InsulinLike Growth Factor-I Gene- Enhanced Mesenchymal Stem Cells Improve Structural Aspects of Healing in Equine Flexor Digitorum Superficialis Tendons. J Orthop Res., v.27, p.1392-1398, 2009.
Schnabel, L.V.; Mohammed, H.O.; Miller, B.J. et al. Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res., v.25, p.230-240, 2007.
Schwartz, A.; Martínez, S.G. Factores de crecimiento derivados de plaquetas y sus aplicaciones en medicina regenerativa. Potencialidades del uso del ozono como activador. Revista Española de Ozonoterapia, v.1, n.1, p.54-73, 2011.
Skjong, C.C.; Meininger, A.K.; Sherwin, S.W. Tendinopathy Treatment: Where is the Evidence. Clin Sports Med, v.31, p.329-350, 2012.
Soleimany, F.A. Platelet activation of platelet concentrates derived from buffy coat and apheresis methods. Transfusion and Apheresis Science, v.44, n.1, p.11-13, 2011.
Sporn, M.; Roberts, A. The multifunctional nature of peptide growth factors. In: Sporn, M.; Roberts, A. (Eds.). Peptide growth factors and their receptors 1 (pp. 3-15). 1st ed., 1990.
Sudman, A.E.; Cole, J.B.; Fortier, A.L. Growth factor and catabolic cytokine Are influenced by the cellular composition of Patelets-Rich-Plasma. The American Journal of Sports Medicine, v.39, n.10, p.2135-2140, 2011.
Sutter, W. PRP: Platelet Rich Plasma. Article, p.1-8, 2007 b.
Sutter, W.W. Autologous Cell-Based Therapy for Tendon and Ligament Injuries. Clinical techniques in equine practice, v.6, p.198-208, 2007a
Sutter, W.W.; Kaneps, A.J.; Bertone, A.L. Comparison of hematologic values and transforming growth factor-b and insulin-like growth factor concentrations in platelet concentrates obtained by use of buffy coat and apheresis methods from equine blood. American Journal of Veterinary Research, v.65, p.924-930, 2004.
Textor, J. Autologous Biologic Treatment for Equine Musculoskeletal Injuries: Platelet-Rich Plasma and IL-1 Receptor Antagonist Protein. Vet Clin Equine, v.27, p.275-298, 2011.
Textor, J.A.; Norris, J.W.; Tablin, F. Effects of preparation method, shear force, and exposure to collagen on release of growth factors from equine platelet-rich plasma. Am J. Vet. Res., v.72, n.2, p.271-278, 2011.
Vendruscolo, C.P.; De M. Carvalho, A.; Moraes, L.F. et al. Avaliação da eficácia de diferentes protocolos de preparo do Plasma Rico em Plaquetas para uso em Medicina Equina1. Pesq. Vet. Bras., v.32, n.2, p.106-110, 2012.
Wallis, T.W.; Baxter, M.G.; Werpy, M.N. et al. Acellular Urinary Bladder Matrix in a Collagenase Model of Superficial Digital Flexor Tendonitis In Horses. Original research, v.30, n.7, p.365- 370, 2010.
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