Authors
Abstract
Introduction: Due to the reduction in the availability of antibiotic-growth promoters in chickens, poultry producers have sought additives to supplement the food, which stimulate the immune system of their birds. Some ß-glucans have been shown to improve gastrointestinal health in chickens when they are challenged by bacteria. Aim: To review the literature on the basic biology of ß-glucans and their use as immunomodulators and growth promoters in chickens. Results and conclusion: ß-glucans increase the flow of dendritic cells, increase the phagocytic capacity of macrophages, and increase the antibody titer after vaccination. Therefore, they function as an anti-inflammatory immunomodulator drug. These substances can provide tools for producers to try to reduce or eliminate the use of poultry growthpromoting antibiotics.
References
Cox, C.M.; Stuard, L.H.; Kim, A.P.; et al. Performance and immune response to dietary ß-Glucans in Broiler Chickens. Poultry Science, v. 89, n.9, p. 124-133, 2010.
EFSA and CDC. 2012.
Fellah, S.J.; Jaffredo. T.; Nagy, N. et al. Development of the Avian Immune System.Avian Immunology, Elsevier 3. p. 51, 2008.
Genovese. K.J.; He, H.; Sawaggerty, C.L et al. The Avian Heterophil. Comparative Immunology, v. 41, n. 3, p. 334-340, 2013.
Gou, Y.; Ali, R.A.; Qureshi, M.A. The influence of ß-glucan on immune response in broiler chickens. Immunopharmacol Immunotoxicol, v. 25, n. 3, p. 461-472, 2003.
Jacob, J.P.; Pescatore, J.A. Barley β-glucans in poultry Diets. Annals of Translational Medicine, v.2, n.2, p. 20, 2014.
Keestra, A.M.; de Zoete, M.R.; Bouman, L.I. et al. Chicken TLR 21 is an innate CpG DNA receptor distinct of a mamilian TLR 9. J. Immunol, v 185, n. 1, 460-467, 2010.
Medizhitov, R.; Preston-Hulburt, P.; Jeneway, C.A Jr. A human homologue of the Drosophila Toll Protein Signals activation of immune adaptive response.Nature, v. 388, n. 6640, p. 394-397, 1997.
Qureshi, M.A. Avian macrophage and immune response: an overview. Poultry Science, v. 82, n. 5, p. 691-698, 2003.
Rathgeber, B.M.; Budgell, K.L.; MacIsaac, J.L. et al. Growth performance and spleen and bursa weight of broilers fed yeast betaglucan. Canadian Journal of Animal Science, v. 88, n. 3, p. 469-473, 2008.
Rojas, X et al. Mucosa del tracto digestivo. Inmunología de Rojas, v. 10, p. 218, 2017.
Shao, Y.; Guo Y.; Wang, Z. Β-1, 3/1,6-Glucanalleviated intestinal mucosal barrier impairment of broiler chickens challenged with Salmonella enterica serovar Typhimurium. Poultry Science, v. 92, n. 7, p. 1764-1773, 2013.
Temperley, N.D.; Berlin, I.R.; Patton, D.K.; et al. Evolution of the Chickens toll-Like receptors gene family: A history of the gene gain and gene loss. BMC Genomics, v. 9, p. 62-74, 2008.
Tizard, I.R. El Complejo Mayor de Histocompatibilidad. Introducción a la Inmunología Veterinaria. 8 Ed. Elsevier España. 2009, 101 p.
Zhang, B.Z.; Guo, Y.; Wang, Z. The modulating effect of β-1, 3/1, 6-glucan Supplementation in the diet on performance and immunological responses of broiler chickens. Asian-Aust. J. Anim. Sci., v. 21, n. 2, p. 237-244, 2008.