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Abstract
Introduction: The β-glucans 1,3/1,6 from the yeast wall of Sacharomyces cereviciae are used as immunomodulators in broilers but there is no data to support their use in poultry farming. Aim: To perform a meta-analysis of the studies that evaluate the immunomodulatory effect of β-glucans from S. cereviciae and their action on the secretion of immunoglobulin A (sIgA) in chickens challenged with Salmonella enteritidis. Methods: A meta-analysis was conducted on the studies reported in the databases: PUB MED, MED LINE and SCIENCE DIRECT, between 2000-2018. Data were evaluated with the QUALITY CONSORT software.Results: The process of systematic review and meta-analysis yielded 30 studies, of which 26 papers that did not meet the requirements and were eliminated. Only four studies that included 356 chickens were analyzed. The ANOVA of the great mean showed a significant increase in the sIgA of chickens treated with a dose of 25mg/Kg of β-glucans compared to control chickens. In addition, a great variation in the production of IgA was observed in doses ranging between 25-100 mg/kg. Likewise, when comparing these doses and their effect with the time of use, it was observed that after 15 days of continuous use of β-glucans the secretion of sIgA remained stable.Conclusions: Dietary supplementation with β-glucans 1,3/1,6 may increase sIgA secretion when is used at a dose of 25 mg/Kg, for a period of 21 days in broilers challenged with Salmonella enteritidis.
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