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Publication Date: 2013-12-20
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Montoya Flórez, L. M. ., Pedraza Ordóñez, F. ., Monteiro, S. ., Seullner Brandão, C. V. ., & Sousa Rocha, N. . (2013). Clinicaland cytological staging of transmissible venereal tumour at the BotucatuVeterinary Hospital. Revista Veterinaria Y Zootecnia (On Line), 7(2), 75–91. Retrieved from https://revistasojs.ucaldas.edu.co/index.php/vetzootec/article/view/4384
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Abstract
ABSTRACT: The canine transmissible venereal tumour is a transplantable neoplasm of great scientific interest for its versatile biological behaviour and its complex mechanisms of evolution. The main objective of this research was to obtain information in order to carry out a better clinical and therapeutic approachof patients with this tumour, twenty dogs with clinical and cytological diagnosis of TVT were studied. Theclinical staging (TNM) was carried out, thecytomorphologicclassification and the nuclear malignancyand cytoplasmic criteria were obtained. TheChi-square test and the MannWhitney test were used for data analysis. Eighteen animals were mixed race with a 2 to 10 range of age, and the main location of the tumor was the external genital and the predominant cellular type was plasmacytoid. Themalignancynuclear and cytoplasmic criteria,with the exception of the perinuclear halo,were similar to those described in the literature. During the RNM classification, two tumours were categorized as T3M and one as T3N1; the other tumours were classified in different T degrees. Despite the lack of statistical significance for the employed method, in general, a good clinical relationship was seen between TNM staging and cytopathological findings, suggesting that both provide greater certainty about the degree of aggressiveness, progression and prognosis in the patients with TVT, as it occurs in other typesof tumours. Use of staging in this tumour can serve as a criterion to suggest the possible evolution and type of therapy.Nevertheless we recommend future research to help define the benefits of using the TNM clinical staging in TVT.
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References
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Amaral, A.S. Tumor venéreo transmissível canino: critérios citológicos de malignidade e caracterização citomorfológica correlacionada a imunocitoquímica e lesões de DNA. Botucatu, Brasil: Universidade Estadual Paulista, 2005, 228p. Tese (Doutorado em Medicina Veterinária) - Faculdade de Medicina Veterinária e Zootecnia.
Amaral, A.S.; Bassani-Silva, S.; Ferreira, I. et al. Cytomorphological characterization of transmissible canine venereal tumor. Revista Portuguesa de Ciências Veterinárias, v.102, p. 253-260, 2007.
Amaral, A.S.; Gaspar, L.F.; Bassani-Silva, S. Cytological diagnostic of transmissible venereal tumour in the Botucatu region, Brazil (descriptive study: 1994- 2003). Revista Portuguesa de Ciências Veterinárias, v.99, n.551, p.167-171, 2004.
Amaral, A.S.; Ferreira, I.; Colodel, M.M.; Fávero, D.M.; Rocha, N.S. DNA damage in canine transmissible venereal tumor. Revista Lusófona de Ciência e Medicina Veterinária. v 4, p. 1-5, 2011.
Bassani-Silva, S. Efeito da própolis sobre a agressividade do tumor venéreo transmissível canino: ensaios in vitro. Botucatu, Brasil: Universidade Estadual Paulista, 2005. 104p. Dissertação (Mestrado em Medicina Veterinária) - Faculdade de Medicina Veterinária e Zootecnia.
Bassani-Silva, S.; Sforcin, J.M.; Amaral, A.S. et al. Propolis effect in vitro on canine transmissible venereal tumour cells. Revista Portuguesa de Ciências Veterinárias, v.102, p. 261-265, 2007.
Booth, M.J. Canine transmissible venereal tumour and ovarian papillary cystadenocarcinoma in a bitch. Journal of Small Animal Practice, v.35, n.1, p.39-42, 1994.
Brandão, C.V.; Borges, A.G.; Ranzani, J.J. et al. Tumor Venéreo Transmissível: estudo retrospectivo de 127 casos (1998-2000). Revista Educação Continuada CRMV-SP, v.5, p.25-31, 2002.
Cheng, L.; Montironi, R.; Bostwick, D.G. et al. Staging of prostate cancer. Histopathology, v.60, p.87-117, 2012.
Cohen, D. The biological behavior of the canine transmissible venereal tumour in imunosupressed dogs. EUR j. Cancer, v.9, p.253-258, 1973.
Cohen, D. The Canine transmissible venereal tumour: a unique result of tumour progression. Advances in Cancer Research, v.43, p.75-112, 1985.
Cowel, R.L.; Tyler, R.D. Cytology of cutaneous lesions. Veterinary Clinics North America: Small Animal Practice, Philadelphia, v.19, p.769-794, 1989.
Cowell, R.L.; Tyler, R.D. Diagnostic cytology and hematology of the dogs and cats. American Veterinary Publications, 1999. 206p.
Das, U.; Das, A.K. Review of canine transmissible venereal sarcoma. Veterinary Research Communications, v.24, p.545-56, 2000.
Duarte, R.; Niero, R.; Doretto, J.S. Eritrocitose associada a tumor venéreo transmissível em cão: relato de caso. Arquivo Brasileiro de Medicina Veterinária Zootecnia, v.58, n. 6, p.1018-23, 2006.
Ferreira, A.J.; Jaggy, A.; Varejão, A.P. Brain and ocular metastases from a transmissible venereal tumour in a dog. Journal of Small Animal Practice, v.41, n.4, p.165-168, 2000.
Fonseca, L.S.; Mota, L.S.; Colodel, M.M. et al. Spontaneous Canine Transmissible Venereal Tumor: association between different phenotypes and the insertion LINE-1/c-myc. Revista Colombiana Ciencias Pecurias, v.25, p.402-408, 2012.
Gaspar, L.F.J. Caracterização citomorfológica do tumor venéreo transmissível canino correlacionada com danos citogenéticos, taxa de proliferação e resposta clínica à quimioterapia. Botucatu, Brasil: Universidade Estadual Paulista, 2005. 143p. Tese (Doutorado em Medicina Veterinária) - Faculdade de Medicina Veterinária e Zootecnia.
Gaspar, L.F.; Amaral, A.S.; Bassani-Silva, S.; Rocha N.S. Imunorreatividade à glicoproteína-p nos diferentes tipos citomorfológicos de tumor venéreo transmissível canino. Veterinária em Foco; v.6, n.2, 2009.
Gaspar, L.F.; Ferreira, I.; Colodel, M.M. et al. Spontaneus canine transmissible venereal tumour: cell morphology and influence on p-glycoprotein expression. Turkish Journal Veterinary Animal Science, v.34, p 447-454, 2010.
Goldschmidt, M.H.; Hendrick, M.J. Tumours of the skin and soft tissues. In: Meuten, D.J. (Ed). Tumours in domestic animals. Ames. Iowa: Iwoa State, 2002. p.45- 117.
Grenings, S. Clinical cytology and cytotechnology. In: Keebler, C.M.; Somrak, T.S. The manual of cytotechnology. 7.ed. Chicago: American Society of Clinical Pathologists, 1993. Chap.2, p.5-16.
Hasler, A.H.; Weber, W.T. Theriogenology question of the month. Transmissible venereal tumour (TVT). Journal of American Veterinary Medical Association, Schaumburg, v.216, n.10, p.1557-1559, 2000. Errata: Theriogenology question of the month. Journal of American Veterinary Medical Association, Schaumburg, v.217, n.1, p.42, 2000.
Hataka, A. Citologia aspirativa com agulha fina e histopatologia: valor e significado para o diagnóstico e prognóstico do câncer de mama em cadelas. Botucatu, Brasil: Universidade Estadual Paulista, 2004. 90p. Tese (Doutorado em Medicina Veterinária) - Faculdade de Medicina Veterinária e Zootecnia.
International Union Against Cancer (UICC). TNM classification of malignant tumors. 5 th and 6 th eds. Geneva: UICC, 1997 and 2002.
Jubb, K.V.F.; Kennedy, P.C.; Palmer, N. Editado por Maxie, G. Pathology of Domestic Animals. Nervous system, 2007, v.1. 7th ed. Elsevier Health Sciences. p.415.
Karayannopoulou, M.; Kaldrymidou, E.; Constantinidis, T.C. et al. Histological grading and prognosis in dogs with mammary carcinomas: application of a human grading method. Journal Comparative Pathology, v.133, p.246-252, 2005.
Kroger, D.; Grey, R.M.; Boyd, J.W. An usual presentation of canine transmissible venereal tumour. Canine Practice, v.16, n.6, p.17-21, 1991.
Lefebvre, G.N.; Bonamin, L.V.; Oliviera, C.M. Tratamento de tumor venéreo transmissível (TVT) canino utilizando Viscum álbum em associação à quimioterapia. Clinical Veterinary, v.70, p.78-86, 2007.
MacEwen, E.G. Transmissible veneral tumour. In: Withrow, S.J., MacEwen, E.G. 3th ed. Small animal clinical oncology. Philadelphia: W.B. Saunders, 2001. p.651-656.
Marchal, T.; Chabanne, L.; Kaplanski, C. Immunophenotype of the canine transmissible venereal tumour. Veterinary Immunology and Immunopathology, v.57, n.1-2, p.1-11, 1997.
Meuten, D.J. Tumours in Domestic Animals. London: University of California Press. 4th ed., 2000. p.115-117, 435, 572.
Montoya, M.; Pedraza, F.; Grandi, F. et al. Cytologic subtypes of canine transmissible venereal tumour. Veterinary Clinical Pathology, v.41, n.1 p.4-5, 2012.
Morrison, W.B. Cancer in dog and cats: medical and surgical management. Printed About in China, Teton New Media, 2 ed., 2002. p.58-60.
Mountain, C.F. Staging classification of lung cancer. Clinics in Chest Medicine, v. 23, p.103-121, 2002.
Nak, D.; Nak, Y.; Cangul, I.T. et al. clinic-pathological study on the effect of vincristine on transmissible venereal tumour in dogs. Journal Veterinary Medicine, v.52, p.366-70, 2005.
Nieslsen, S.W.; Kennedy, P.C. Tumors of the genital systems. In: Tumours in domestic animals. 3a edição. Editor: Moulton, J.E. University of California Press (Berkeley, Los Angeles, London), 1990. p.479-517.
Owen, L.N. World Health Organization TNM classification of tumors in domestic animals. Geneva: WHO, 1980.
Pandey, S.K.; Chandrapuria, V.P.; Bhargava, M.K.; Tiwari, S.K. Incidence, treatment approach and metastasis of canine transmissible venereal sarcoma. Indian Journal of Animal Sciences, v. 59, p. 510-513, 1989.
Papazoglou, L.G.; Koutinas, A.F.; Plevraki, A.G. Primary intranasal Transmissible Venereal Tumour in the dog: a retrospective study of six spontaneous cases. Journal of Veterinary Medicine Series A, v.48, n.7, p.391-400, 2001.
Park, M.S.; Kim, Y.; Kang, M.S. Disseminated transmissible venereal tumour in a dog. Journal of Veterinary Diagnostic Investigation, v.18, n.1, p. 130- 133, 2006.
Pereira, J.S.; Silva, A.B.; Martins, A.L. Immunohistochemical characterization of intraocular metastasis of a canine transmissible venereal tumour.Veterinary Ophthalmology, v.3, n.1, p.43-47, 2000.
Rodrigues, G.N.; Alessi, A.C.; Laus, J.L. Intraocular transmissible venereal tumour in a dog. Ciência Rural, v.31, n.1, p.141-143, 2001.
Rogers, K.S. Transmissible venereal tumor. The Compendium on Continuing Education for the Practicing Veterinarian. Princeton Junction, v.19, n.9, p.1036-1045, 1997.
Rogers, K.S.; Walker, M.A.; Dillon, H.B. Transmissible venereal tumour: a retrospective study of 29 cases. Journal of the American Animal Hospital Association, v.34, n.6, p.463-470, 1998.
Romero, R.R.; García de Jalón, J.A.; Nevárez, A.M. et al. Transmissible venereal tumour with metastasis to a spleen hemangioma in a bitch. Veterinary México, v.41, n.4, p.305-310, 2010.
Santos, F.G.; Vasconcelos, A.C.; Nunes, J.E.; Cassali, G.D.; Paixão, T.A. Martins, A.S.; Silva, S.S.; Martins, R.F.; Moro, L. Apoptosis in the transplanted canine transmissible venereal tumor during growth and regression phases Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v.60, n.3, p.607-612, 2008.
Varaschin, M.S.; Wouters, F.; Bernins, V.M. Tumor venéreo transmissível canino na região de Alfenas, Minas Gerais; formas de apresentação clínicopatológicas. Clínica Veterinária, v.6, n.32, p.32-38, 2001.
Wright, P.J.; Parry, B.W. Cytology of the canine reproductive system. Veterinary Clinics of North America: Small Animal Practice, Philadelphia, v.19, p.851-874, 1989.
Yang, T.J.; Jones, J.B. Canine transmissible venereal sarcoma - Transplantation studies in neonatal and adult dogs. Journal of National Cancer Institute, v.51, p.1915-1918, 1973.
Amaral, A.S. Tumor venéreo transmissível canino: critérios citológicos de malignidade e caracterização citomorfológica correlacionada a imunocitoquímica e lesões de DNA. Botucatu, Brasil: Universidade Estadual Paulista, 2005, 228p. Tese (Doutorado em Medicina Veterinária) - Faculdade de Medicina Veterinária e Zootecnia.
Amaral, A.S.; Bassani-Silva, S.; Ferreira, I. et al. Cytomorphological characterization of transmissible canine venereal tumor. Revista Portuguesa de Ciências Veterinárias, v.102, p. 253-260, 2007.
Amaral, A.S.; Gaspar, L.F.; Bassani-Silva, S. Cytological diagnostic of transmissible venereal tumour in the Botucatu region, Brazil (descriptive study: 1994- 2003). Revista Portuguesa de Ciências Veterinárias, v.99, n.551, p.167-171, 2004.
Amaral, A.S.; Ferreira, I.; Colodel, M.M.; Fávero, D.M.; Rocha, N.S. DNA damage in canine transmissible venereal tumor. Revista Lusófona de Ciência e Medicina Veterinária. v 4, p. 1-5, 2011.
Bassani-Silva, S. Efeito da própolis sobre a agressividade do tumor venéreo transmissível canino: ensaios in vitro. Botucatu, Brasil: Universidade Estadual Paulista, 2005. 104p. Dissertação (Mestrado em Medicina Veterinária) - Faculdade de Medicina Veterinária e Zootecnia.
Bassani-Silva, S.; Sforcin, J.M.; Amaral, A.S. et al. Propolis effect in vitro on canine transmissible venereal tumour cells. Revista Portuguesa de Ciências Veterinárias, v.102, p. 261-265, 2007.
Booth, M.J. Canine transmissible venereal tumour and ovarian papillary cystadenocarcinoma in a bitch. Journal of Small Animal Practice, v.35, n.1, p.39-42, 1994.
Brandão, C.V.; Borges, A.G.; Ranzani, J.J. et al. Tumor Venéreo Transmissível: estudo retrospectivo de 127 casos (1998-2000). Revista Educação Continuada CRMV-SP, v.5, p.25-31, 2002.
Cheng, L.; Montironi, R.; Bostwick, D.G. et al. Staging of prostate cancer. Histopathology, v.60, p.87-117, 2012.
Cohen, D. The biological behavior of the canine transmissible venereal tumour in imunosupressed dogs. EUR j. Cancer, v.9, p.253-258, 1973.
Cohen, D. The Canine transmissible venereal tumour: a unique result of tumour progression. Advances in Cancer Research, v.43, p.75-112, 1985.
Cowel, R.L.; Tyler, R.D. Cytology of cutaneous lesions. Veterinary Clinics North America: Small Animal Practice, Philadelphia, v.19, p.769-794, 1989.
Cowell, R.L.; Tyler, R.D. Diagnostic cytology and hematology of the dogs and cats. American Veterinary Publications, 1999. 206p.
Das, U.; Das, A.K. Review of canine transmissible venereal sarcoma. Veterinary Research Communications, v.24, p.545-56, 2000.
Duarte, R.; Niero, R.; Doretto, J.S. Eritrocitose associada a tumor venéreo transmissível em cão: relato de caso. Arquivo Brasileiro de Medicina Veterinária Zootecnia, v.58, n. 6, p.1018-23, 2006.
Ferreira, A.J.; Jaggy, A.; Varejão, A.P. Brain and ocular metastases from a transmissible venereal tumour in a dog. Journal of Small Animal Practice, v.41, n.4, p.165-168, 2000.
Fonseca, L.S.; Mota, L.S.; Colodel, M.M. et al. Spontaneous Canine Transmissible Venereal Tumor: association between different phenotypes and the insertion LINE-1/c-myc. Revista Colombiana Ciencias Pecurias, v.25, p.402-408, 2012.
Gaspar, L.F.J. Caracterização citomorfológica do tumor venéreo transmissível canino correlacionada com danos citogenéticos, taxa de proliferação e resposta clínica à quimioterapia. Botucatu, Brasil: Universidade Estadual Paulista, 2005. 143p. Tese (Doutorado em Medicina Veterinária) - Faculdade de Medicina Veterinária e Zootecnia.
Gaspar, L.F.; Amaral, A.S.; Bassani-Silva, S.; Rocha N.S. Imunorreatividade à glicoproteína-p nos diferentes tipos citomorfológicos de tumor venéreo transmissível canino. Veterinária em Foco; v.6, n.2, 2009.
Gaspar, L.F.; Ferreira, I.; Colodel, M.M. et al. Spontaneus canine transmissible venereal tumour: cell morphology and influence on p-glycoprotein expression. Turkish Journal Veterinary Animal Science, v.34, p 447-454, 2010.
Goldschmidt, M.H.; Hendrick, M.J. Tumours of the skin and soft tissues. In: Meuten, D.J. (Ed). Tumours in domestic animals. Ames. Iowa: Iwoa State, 2002. p.45- 117.
Grenings, S. Clinical cytology and cytotechnology. In: Keebler, C.M.; Somrak, T.S. The manual of cytotechnology. 7.ed. Chicago: American Society of Clinical Pathologists, 1993. Chap.2, p.5-16.
Hasler, A.H.; Weber, W.T. Theriogenology question of the month. Transmissible venereal tumour (TVT). Journal of American Veterinary Medical Association, Schaumburg, v.216, n.10, p.1557-1559, 2000. Errata: Theriogenology question of the month. Journal of American Veterinary Medical Association, Schaumburg, v.217, n.1, p.42, 2000.
Hataka, A. Citologia aspirativa com agulha fina e histopatologia: valor e significado para o diagnóstico e prognóstico do câncer de mama em cadelas. Botucatu, Brasil: Universidade Estadual Paulista, 2004. 90p. Tese (Doutorado em Medicina Veterinária) - Faculdade de Medicina Veterinária e Zootecnia.
International Union Against Cancer (UICC). TNM classification of malignant tumors. 5 th and 6 th eds. Geneva: UICC, 1997 and 2002.
Jubb, K.V.F.; Kennedy, P.C.; Palmer, N. Editado por Maxie, G. Pathology of Domestic Animals. Nervous system, 2007, v.1. 7th ed. Elsevier Health Sciences. p.415.
Karayannopoulou, M.; Kaldrymidou, E.; Constantinidis, T.C. et al. Histological grading and prognosis in dogs with mammary carcinomas: application of a human grading method. Journal Comparative Pathology, v.133, p.246-252, 2005.
Kroger, D.; Grey, R.M.; Boyd, J.W. An usual presentation of canine transmissible venereal tumour. Canine Practice, v.16, n.6, p.17-21, 1991.
Lefebvre, G.N.; Bonamin, L.V.; Oliviera, C.M. Tratamento de tumor venéreo transmissível (TVT) canino utilizando Viscum álbum em associação à quimioterapia. Clinical Veterinary, v.70, p.78-86, 2007.
MacEwen, E.G. Transmissible veneral tumour. In: Withrow, S.J., MacEwen, E.G. 3th ed. Small animal clinical oncology. Philadelphia: W.B. Saunders, 2001. p.651-656.
Marchal, T.; Chabanne, L.; Kaplanski, C. Immunophenotype of the canine transmissible venereal tumour. Veterinary Immunology and Immunopathology, v.57, n.1-2, p.1-11, 1997.
Meuten, D.J. Tumours in Domestic Animals. London: University of California Press. 4th ed., 2000. p.115-117, 435, 572.
Montoya, M.; Pedraza, F.; Grandi, F. et al. Cytologic subtypes of canine transmissible venereal tumour. Veterinary Clinical Pathology, v.41, n.1 p.4-5, 2012.
Morrison, W.B. Cancer in dog and cats: medical and surgical management. Printed About in China, Teton New Media, 2 ed., 2002. p.58-60.
Mountain, C.F. Staging classification of lung cancer. Clinics in Chest Medicine, v. 23, p.103-121, 2002.
Nak, D.; Nak, Y.; Cangul, I.T. et al. clinic-pathological study on the effect of vincristine on transmissible venereal tumour in dogs. Journal Veterinary Medicine, v.52, p.366-70, 2005.
Nieslsen, S.W.; Kennedy, P.C. Tumors of the genital systems. In: Tumours in domestic animals. 3a edição. Editor: Moulton, J.E. University of California Press (Berkeley, Los Angeles, London), 1990. p.479-517.
Owen, L.N. World Health Organization TNM classification of tumors in domestic animals. Geneva: WHO, 1980.
Pandey, S.K.; Chandrapuria, V.P.; Bhargava, M.K.; Tiwari, S.K. Incidence, treatment approach and metastasis of canine transmissible venereal sarcoma. Indian Journal of Animal Sciences, v. 59, p. 510-513, 1989.
Papazoglou, L.G.; Koutinas, A.F.; Plevraki, A.G. Primary intranasal Transmissible Venereal Tumour in the dog: a retrospective study of six spontaneous cases. Journal of Veterinary Medicine Series A, v.48, n.7, p.391-400, 2001.
Park, M.S.; Kim, Y.; Kang, M.S. Disseminated transmissible venereal tumour in a dog. Journal of Veterinary Diagnostic Investigation, v.18, n.1, p. 130- 133, 2006.
Pereira, J.S.; Silva, A.B.; Martins, A.L. Immunohistochemical characterization of intraocular metastasis of a canine transmissible venereal tumour.Veterinary Ophthalmology, v.3, n.1, p.43-47, 2000.
Rodrigues, G.N.; Alessi, A.C.; Laus, J.L. Intraocular transmissible venereal tumour in a dog. Ciência Rural, v.31, n.1, p.141-143, 2001.
Rogers, K.S. Transmissible venereal tumor. The Compendium on Continuing Education for the Practicing Veterinarian. Princeton Junction, v.19, n.9, p.1036-1045, 1997.
Rogers, K.S.; Walker, M.A.; Dillon, H.B. Transmissible venereal tumour: a retrospective study of 29 cases. Journal of the American Animal Hospital Association, v.34, n.6, p.463-470, 1998.
Romero, R.R.; García de Jalón, J.A.; Nevárez, A.M. et al. Transmissible venereal tumour with metastasis to a spleen hemangioma in a bitch. Veterinary México, v.41, n.4, p.305-310, 2010.
Santos, F.G.; Vasconcelos, A.C.; Nunes, J.E.; Cassali, G.D.; Paixão, T.A. Martins, A.S.; Silva, S.S.; Martins, R.F.; Moro, L. Apoptosis in the transplanted canine transmissible venereal tumor during growth and regression phases Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v.60, n.3, p.607-612, 2008.
Varaschin, M.S.; Wouters, F.; Bernins, V.M. Tumor venéreo transmissível canino na região de Alfenas, Minas Gerais; formas de apresentação clínicopatológicas. Clínica Veterinária, v.6, n.32, p.32-38, 2001.
Wright, P.J.; Parry, B.W. Cytology of the canine reproductive system. Veterinary Clinics of North America: Small Animal Practice, Philadelphia, v.19, p.851-874, 1989.
Yang, T.J.; Jones, J.B. Canine transmissible venereal sarcoma - Transplantation studies in neonatal and adult dogs. Journal of National Cancer Institute, v.51, p.1915-1918, 1973.
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