La lidocaína en terapéutica veterinaria: posibles nuevos usos desde la perspectiva farmacocinética y farmacodinámica

Abstract

In pharmacological therapeutics drugs available for decades have been revised against new applications and, for some pathologies in veterinary medicine, the therapeutic options may be unlimited so that, any new application is relevant for professional practice. This article aims to identify new uses and possibilities of application of lidocaine in veterinary medicine from its pharmacokinetic and pharmacodynamics profile by reviewing the theoretical and methodological approaches developed recently on the subject. Many of the updates that apply to human medicine can be implemented in veterinary medicine just as the studies in their early stages need positive results in animals, so that the therapeutic potential of a substance can be quickly valued in the field of veterinary medicine. Data was collected through databases, books and scientific magazines search with publications of studies in humans or animals and the combination of results was made in four specific issues: lidocaine as a prokinetic agent; lidocaine as anesthetic and analgesic; lidocaine against antimicrobial activity; and lidocaine as protective agent in the ischemia reperfusion injury. This way, the proposal is to apply the use of this substance in more situations than the conventional ones in the professional veterinary activity.

Keywords

pharmacology

prokinetic

anesthetic

anestheticlidocaine

analgesic

lidocaine

References

 Jeon, Y.-T. et al. Modulation of Dendritic Cell Activation and Subsequent Th1 Cell Polarization by Lidocaine. PLOS ONE, v. 10, n. 10, p. e0139845, 2015.

 Mejía, M.; Nova, A. Evaluación intraoperatoria y postoperatoria del efecto analgésico de infusiones intravenosas de tramadol, ketamina, lidocaína y su combinación, en hembras caninas sometidas a ovariohisterectomía. Bogotá, Colombia: Universidad de La Salle, 2014. Tesis (Médico Veterinario).

 Moreta, EM. Evaluación de fentanilo, lidocaína y ketamina como analgésico postoperatorio en perros sometidos a diferentes tipos de cirugía en la clínica veterinaria huellitas, cantón San Miguel, provincia Bolívar. Disponible en: http://localhost:8080/xmlui/handle/123456789/1240. Accesado en: 10/07/2018.

 Morgaz, J. et al. Effectiveness of Pre-Peritoneal Continuous Wound Infusion with Lidocaine for Pain Control Following Ovariohysterectomy in Dogs. Veterinary Journal, v. 202, n. 3, p. 522-526, 2014.

 Ortega, M. Efecto de la lidocaína en el tratamiento de la retención placentaria y metritis puerperal en ganado lechero. bdigital.zamorano.edu. Disponible en: https://bdigital.zamorano.edu/handle/11036/2074. Accesado en: 10/07/2018.

 Ramírez-Tapia, D. Efecto de la lidocaina sobre el desarrollo de infección por escherichia coli en el sitio operatorio superficial en ratas wistar. Disponible en: http://tesis.ipn.mx:8080/xmlui/handle/123456789/10141. Accesado en: 10/07/2018.

 Smith, L.J. et al. Systemic Lidocaine Infusion as an Analgesic for Intraocular Surgery in Dogs: A Pilot Study. Veterinary Anaesthesia and Analgesia, v. 31, n. 1, p. 53-63, 2004.

 Sumano, H.S.; Ocampo L. Farmacología veterinaria. Ciudad de México: McGrawHill Interamericana, 2006. 1082p.

 Yamabayashi, K. et al. Lidocaine Protects against Myocardial Ischemia-Reperfusion Injury in Anesthetized Rabbits. Journal of Osaka Dental University, v. 47, n. 2, p.201-207, 2013.