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Fecha Publicación: 2010-06-18
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Delgado García, L. M., Linares Villalba, S., & Laus, J. L. (2010). Defecto espontáneo crónico del epitelio corneal en caninos: patofisiología y terapéutica. Revista Veterinaria Y Zootecnia (On Line), 4(1), 63–82. Recuperado a partir de https://revistasojs.ucaldas.edu.co/index.php/vetzootec/article/view/5616
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RESUMEN: Las patologías del segmento anterior del ojo representan uno de los motivos más frecuentes de consulta oftalmológica en pequeños animales, dada su evidencia y fácil observación de signos clínicos. En Colombia, su estudio, se encuentra más avanzado en el campo de la medicina humana. El defecto espontáneo crónico del epitelio corneal se describe como una úlcera corneal superficial que cicatriza pobremente tendiendo a recidivas. El propósito de este trabajo es caracterizar su patofisiología y diagnóstico en caninos y enumerar los tratamientos médicos y quirúrgicos utilizados actualmente. Además se abordará un capítulo previo sobre anatomía y cicatrización corneal. Planear el tratamiento de esta entidad de forma inteligente, como en muchas otras enfermedades, requiere conocer previamente todas las condiciones que podrían estar produciendo y empeorando las lesiones que son evidentes, su forma de solucionarlas y el control minucioso del paciente.
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Arican, M.; Ceylan, C. Metalloproteinases in Canine Experimental Traumatic Keratoconjuntivitis. Journal of Veterinary Medicine. Berlin. Ed Blackwell Wissenschafts-Verlag, n.46, p.527- 532, 1999.
Bacchini, M.; Simonazzi, B. Le Patologie Oculari del Boxer: Studio Retrospettivo. Annais Facoltà di Medicina Veterinaria di Parma, Università Studi di Parma. Parma, Italia, v .26, p.341-358. 2006.
Barros, L.F.M.; Barros, P.S.M.; Ropke, C.D.; Silva, V.V.; Sawada, T.C.H.; Barros, S.B.M.; Belfort Jr., R. Dose-dependent in vitro inhibition of rabbit corneal matrix metalloproteinases by an extract of Pothomorphe umbellata after alkali injury. Brazilian Journal of Medical and Biological Research. São Paulo. Brazil, n.40, p.1129-1132,2007.
Barros, P.S.M.; Safatle, A.M.V.; Godoy, C.A.; Souza, M.S.B.; Barros, L.F.M.; Brooks, D.E. Amniotic Membrane transplantation for the reconstruction of the ocular surface in three cases. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.8, n.3, p.189-192, 2005.
Bentley, E.; Abrams, G.A.; Covitz, D.; Cook, C.S.; Fischer, C.A.; Hacker, D.; Stuhr, C.M.; Reid, T.W.; Murphy, C.J. Morphology and Immunohistochemistry of Spontaneous Chronic Corneal Epithelial Defects (SCCED) in Dogs. Investigative Ophthalmology & Visual Science (IOVS), Association for Research in Vision and Ophthalmology, v.42, n.10, p.2262-2269, 2001.
Bentley, E.; Campbell, S.; Woo, H.M.; Murphy, C.J. The Effect of Chronic Corneal Epithelial Debridement on Epithelial and Stromal Morphology in Dogs. Investigative Ophthalmology & Visual Science (IOVS), Association for Research in Vision and Ophthalmology, v.43, n.7, p.2136-2142, 2002.
Bromberg, N.M. Cyanoacrylate tissue adhesive for treatment of refractory corneal ulceration. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.5, n.1, P.55-60, 2002.
Campos, C.F.; Jorge, A.T.; Talieri, I.C.; Mendes, F.A.; Toledo-Piza, E.; Laus, J.L. Ocular alkali lesions in dogs. Acetylcysteine and blood serum effects. Brazilian Journal of Veterinary Research and Animal Science, São Paulo, Brazil. n.40, p.36- 44, 2003.
Choi, S.U.; Labelle, P.; Kim, S.; Kim, J.; Cha, J.; Lee, K.Ch.; Lee, H.B.; Kim, N.S.; Kim, M.S. Case Report. Successful treatment of an unusually large corneal epithelial inclusion cyst using equine amniotic membrane in a dog. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.13, n.2, p.122-125, 2010.
Couture, S.; Doucet, M.; Doucet, M.M.; Carrier, M. Topical effect of various agents on gelatinase activity in the tear film of normal dogs. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.9, n.3, p.157-164, 2006.
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Gilmour, M.A. Laser Applications for Corneal Disease. Clinical Techniques in Small Animal Practice. Ed. Elsevier Inc, v.18, n.3, p.199-202, 2003.
Giordano, C.; Crotti, A. Le patologie dell segmento anteriore dell’occhio ed il loro trattamento nella pratica medica negli animali d’affezione. Rivista Zootecnia e Veterinaria, v.39, n.2, p.41-54, 2008.
Hendrix, D.V.H. Eye examination Techniques in Horses. Clinical Techniques in Equine Practice, College of Veterinary Medicine, The University of Georgia. Ed. Elsevier Saunders Company, n.4, p.2-10, 2005.
Hendrix, D.V.H.; Ward, D.A.; Barnhill, M.A. Effects of anti-inflammatory drugs and preservatives on morphologic characteristics and migration of canine corneal epithelial cells in tissue culture. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.5, n.2, p.127-135, 2002.
Hu, CH.; Ding, Y.; Chen, J.; Liu, D.; Zhang, Y.; Ding, M.; Wang, G. Basic fibroblast growth factor stimulates epithelial cell growth and epithelial wound healing in canine corneas. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.12, n.3, p.170-175, 2009.
Kafarnik, C. Fritshe, J. Reese, S. Corneal Innervation in mesocephalic and brachycephalic dogs and cats: assessment using in vivo confocal microscopy. Veterinary Ophthalmology. American College of Veterinary Ophthalmologists (ACVO). N.11, pp 363-367. 2008.
Kafarnik, C. Fritshe, J. Reese, S. In vivo confocal microscopy in the normal corneas of cats, dogs and birds. Veterinary Ophthalmology. American College of Veterinary Ophthalmologists (ACVO). N.10, pp 222-230. 2007.
Kim, J.Y.; Choi, M.Y.; Jeong, S.W.; Williams, D.L. Effect of bovine freeze-dried amniotic membrane (Amnisite-BATM) on uncomplicated canine corneal erosion. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.12. n.1, p.36-42, 2009.
Kim, J.T.; Chun, Y.S.; Song, G.Y.; Kim, J.Ch. The effect of In Vivo Grown Corneal Epithelium Transplantation on Persistent Epithelial Defects with Limbal Stem Cell Deficiency. Journal Korean Medicine Science, The Korean Academy of Medical Science, n.23, p.502-508, 2008.
Laus, J.L. Oftalmologia clinica e cirúrgica em cães e em gatos. São Paulo, Brasil: Editorial Roca Ltda., 2009. p.69-75.
Ledbetter, E.C.; Munger, R.J.; Ring, R.D.; Scarlett, J.M. Efficacy of two chondroitin sulfate ophthalmic solutions in the therapy of spontaneous chronic corneal epithelial defects and ulcerative keratitis associated with bullous keratopathy in dogs. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.9,
n.2, p.77-87, 2006.
Ma, D.; Kuo, M-T.; Tsai, Y-J.; Chen, H-CJ.; Chen, X-L.; Wang, L.L.; Hsiao, C-H.; Lin, K-K. Transplantation of cultivated oral mucosal epithelial cells for severe corneal burn. Clinical study. Eye. Macmillan Publishers Limited. N.23, .1442-1450, 2009.
Marfurt, C.F.; Murphy, C.J.; Florczak, J.L. Morphology and Neurochemistry of Canine Corneal Innervation. Investigation Ophthalmology Visual Science, v.42, n.10, p.2242-2251, 2001.
Montiani-Ferreira, F. Petersen-Jones, S. Cassotis, N. Ramsey, D. Gearhart, P. Cardoso, F. Early postnatal development of central thickness in dogs. Veterinary Ophthalmology. American College of Veterinary Ophthalmologists (ACVO). Vol. 6, N.1, pp 19-22. 2003.
Moore, P.A. Diagnosis and Management of Chronic Corneal Epithelial Defects (Indolent Corneal Ulcerations). Clinical Techniques in Small Animal Practice, United States. Ed. Mosby Elsevier. V.18, n.3, p.168-177, 2003.
Müller, L. Marfurt, C. Kruse, F. Tervo, T. Review. Corneal nerves: structure, contents and function. Experimental Eye Research. United States. Ed Elsevier Science Ltd.. N.76, pp 521-542. 2003.
Murphy, C.; Marfurt, C.F.; McDermott, A.; Bentley, E.; Abrams, G.A.; Reid, T.W.; Campbell, S. Spontaneous Chronic Corneal Epithelial Defects (SCCED) in Dogs: Clinical Features, Innervation, and Effect of Topical SP, with or without IGF-1. Investigative Ophthalmology & Visual Science (IOVS), Association for Research in Vision and Ophthalmology. V.42, n.10, p.2252-2261, 2001.
Myrna, K. Pot, S. Murphy, C. Meet the corneal myofibroblast: the role of myofibroblast transformation in corneal wound healing and pathology. Review. Veterinary Ophthalmology. American College of Veterinary Ophthalmologists (ACVO). V. 12, Supplement 1, pp 25-35. 2009.
Nagayasu, A.; Hosaka, Y.; Yamasaki, A.; Tsuzuki, K.; Ueda, H.; Honda, T.; Takehana, K. A Preliminary Study of Direct Application of Atelocollagen into a Wound Lesion in the Dog Cornea. Current Eye Research, Informa healthcare. United States. Ed. Taylor & Francis ltd. V.22, p.727-735, 2008.
Ollivier, F.J.; Gilger, B.C.; Barrie, K.P.; Kallberg, M.E.; Plummer, C.E.; O’Reilly, S.; Gelatt, K.N.; Brooks, D.E. Proteinases of the cornea and preocular tear film. Invited Review. Veterinary Ophthalmology, American College of Veterinary Ophthalmologist (ACVO), v.10, n.4, p.199-206., 2007.
Ollivier, F.J.; Kallberg, M.E.; Plummer, C.E.; Barrier, K.P.; O´Reilly, S.; Taylor, D.P.; Gelatt, K.N.; Brooks, D.E. Amniotic membrane transplantation for corneal surface reconstruction after excision of corneolimbal squamous cell carcinomas in nine horses. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.9, n.6, p.404-413, 2006.
Ollivier, F.J. Medical and Surgical Management of Melting Corneal Ulcers Exhibiting Hyperproteinase Activity in the Horse. Clinical Techniques in Equine Practice. Ed. Elsevier Saunders. n.4, p.50-71, 2005.
Pal-Ghosh, S. Pajoohesh-Ganji, A. Brown, M. Ann, M. A Mouse Model for the Study of Recurrent Corneal Epithelial Erosions: α9β1 Integrin Implicated in Progression of the Disease. Investigation Ophthalmology Visual Science, v.45, n.6, p.1775-1788, 2004.
Plummer, C.E. Review. The use of amniotic membrane transplantation for ocular surface reconstruction: a review and series of 58 equine clinical cases (2002-2008). Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), n.12, suppl.1, p.17-24, 2009.
Regnier, A.; Cazalot, G.; Cantaloube, B. Topical treatment of non-healing corneal epithelial ulcers in dogs with aminocaproic acid. Vet. Rec., v.157, n.17, p.510-513, 2006.
Sampaio, R.L.; Ranzani, J.J.T.; Rodrigues Junior, V.; Stacciarini, M.S.; Braga, E.M.; Borrezzi, C. Aspectos clinicos e imunopatológicos da ceratoplastia com membrana amniotica xenógena fresca e conservada em glicerina. Estudo experimental em coelhos. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v.58, n.6, p.1077-1085, 2006.
Slatter, D. Fundamentos de oftalmologia veterinária. 3.ed. São Paulo, Brasil: Editorial Roca Ltda., 2005. p.283-339.
Stanley, R.G.; Hardman, Ch.; Johnson, B.W. Results of grid keratotomy, superficial keratotomy and debridement for the management of persistent corneal erosion in 92 dogs. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), n.1, p.233-238, 1998.
Teixeira, R.B.; Barros, P.S.M.; Martins, M.C. Effects of topical 2% cyclosporine A on the corneas of dogs subjected to lamellar keratoplasty with a graft of equine pericardium preserved in glycerin: clinical and morphological evaluation. Ciência Rural, v.34, n.1, p.131-138, 2004.
Tsuzuki, K.; Yamashita, K.; Izumisawa, Y.; Kotani, T. Microstructure and glycosaminoglycan ratio of canine cornea after reconstructive transplantation with glycerin-preserved porcine amniotic membranes. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.11, n.4, p.222-227, 2008.
Vestre, W.A. Olho. Cornea. En: Bojrab, M.J.; Birchard, S.J.; Tomlinson, J.L. Técnicas Atuais em Cirurgia de Pequenos Animais. 3.ed. São Paulo, Brasil: Editorial Roca Ltda., 1996. pp, ---.
Vicenti, F.A.; Laus, J.L.; Costa Neto, J.M.; Talieri, C.; Campos, C.F.; Jorge, A.T.; Ferreira, A.L.; Fantinatti, A.P. Effects of low-intensity pulsed ultrasound on wound healing in corneas of dogs following keratoplasty. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.6, n.3, p.255-263, 2003.
Werner, A.; Braun, M.; Kietzmann, M. Isolation and cultivation of canine corneal cells for in vitro studies on the anti-inflamatory effects of dexamethasone. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.11, n.2, p.67-74, 2008.
Wichayacoop, T.; Briksawan, P.; Tuntivanich, P.; Yibchok-Anun, S. Anti-inflammatory effects of topical supernatant from human amniotic membrane cell culture on canine deep corneal ulcer after human amniotic membrane transplantation. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.12, n.1, pp 28-25, 2009.
Willeford, K.O.; Miller, W.W.; Abrams, K.L.; Vaughn, B.M. Modulation of proteolytic activity associated with persistent corneal ulcers in dogs. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.1, n.1, p.5-8, 1998.
Woo, H.M.; Bentley, E.; Campbell, S.F.; Marfurt, C.F.; Murphy, C.J. Nerve growth factor and corneal wound healing in dogs. Experimental Eye Research. United States. Ed. Mosby Elsevier. N.80, p.633-642, 2005.
Arican, M.; Ceylan, C. Metalloproteinases in Canine Experimental Traumatic Keratoconjuntivitis. Journal of Veterinary Medicine. Berlin. Ed Blackwell Wissenschafts-Verlag, n.46, p.527- 532, 1999.
Bacchini, M.; Simonazzi, B. Le Patologie Oculari del Boxer: Studio Retrospettivo. Annais Facoltà di Medicina Veterinaria di Parma, Università Studi di Parma. Parma, Italia, v .26, p.341-358. 2006.
Barros, L.F.M.; Barros, P.S.M.; Ropke, C.D.; Silva, V.V.; Sawada, T.C.H.; Barros, S.B.M.; Belfort Jr., R. Dose-dependent in vitro inhibition of rabbit corneal matrix metalloproteinases by an extract of Pothomorphe umbellata after alkali injury. Brazilian Journal of Medical and Biological Research. São Paulo. Brazil, n.40, p.1129-1132,2007.
Barros, P.S.M.; Safatle, A.M.V.; Godoy, C.A.; Souza, M.S.B.; Barros, L.F.M.; Brooks, D.E. Amniotic Membrane transplantation for the reconstruction of the ocular surface in three cases. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.8, n.3, p.189-192, 2005.
Bentley, E.; Abrams, G.A.; Covitz, D.; Cook, C.S.; Fischer, C.A.; Hacker, D.; Stuhr, C.M.; Reid, T.W.; Murphy, C.J. Morphology and Immunohistochemistry of Spontaneous Chronic Corneal Epithelial Defects (SCCED) in Dogs. Investigative Ophthalmology & Visual Science (IOVS), Association for Research in Vision and Ophthalmology, v.42, n.10, p.2262-2269, 2001.
Bentley, E.; Campbell, S.; Woo, H.M.; Murphy, C.J. The Effect of Chronic Corneal Epithelial Debridement on Epithelial and Stromal Morphology in Dogs. Investigative Ophthalmology & Visual Science (IOVS), Association for Research in Vision and Ophthalmology, v.43, n.7, p.2136-2142, 2002.
Bromberg, N.M. Cyanoacrylate tissue adhesive for treatment of refractory corneal ulceration. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.5, n.1, P.55-60, 2002.
Campos, C.F.; Jorge, A.T.; Talieri, I.C.; Mendes, F.A.; Toledo-Piza, E.; Laus, J.L. Ocular alkali lesions in dogs. Acetylcysteine and blood serum effects. Brazilian Journal of Veterinary Research and Animal Science, São Paulo, Brazil. n.40, p.36- 44, 2003.
Choi, S.U.; Labelle, P.; Kim, S.; Kim, J.; Cha, J.; Lee, K.Ch.; Lee, H.B.; Kim, N.S.; Kim, M.S. Case Report. Successful treatment of an unusually large corneal epithelial inclusion cyst using equine amniotic membrane in a dog. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.13, n.2, p.122-125, 2010.
Couture, S.; Doucet, M.; Doucet, M.M.; Carrier, M. Topical effect of various agents on gelatinase activity in the tear film of normal dogs. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.9, n.3, p.157-164, 2006.
Farjo, Q.A. Preface. In: Yanoff, M.; Duker, J.S. Ophthalmology. 3. Ed. United States. Editorial Mosby Elsevier. 2009. p.318-328. Gelatt, K.N. Manual de oftalmologia Veterinária.3.ed. São Paulo, Brasil: Ed Manole Ltda., 2003. p.1-27, 125-165, 531-550.
Gilmour, M.A. Laser Applications for Corneal Disease. Clinical Techniques in Small Animal Practice. Ed. Elsevier Inc, v.18, n.3, p.199-202, 2003.
Giordano, C.; Crotti, A. Le patologie dell segmento anteriore dell’occhio ed il loro trattamento nella pratica medica negli animali d’affezione. Rivista Zootecnia e Veterinaria, v.39, n.2, p.41-54, 2008.
Hendrix, D.V.H. Eye examination Techniques in Horses. Clinical Techniques in Equine Practice, College of Veterinary Medicine, The University of Georgia. Ed. Elsevier Saunders Company, n.4, p.2-10, 2005.
Hendrix, D.V.H.; Ward, D.A.; Barnhill, M.A. Effects of anti-inflammatory drugs and preservatives on morphologic characteristics and migration of canine corneal epithelial cells in tissue culture. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.5, n.2, p.127-135, 2002.
Hu, CH.; Ding, Y.; Chen, J.; Liu, D.; Zhang, Y.; Ding, M.; Wang, G. Basic fibroblast growth factor stimulates epithelial cell growth and epithelial wound healing in canine corneas. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.12, n.3, p.170-175, 2009.
Kafarnik, C. Fritshe, J. Reese, S. Corneal Innervation in mesocephalic and brachycephalic dogs and cats: assessment using in vivo confocal microscopy. Veterinary Ophthalmology. American College of Veterinary Ophthalmologists (ACVO). N.11, pp 363-367. 2008.
Kafarnik, C. Fritshe, J. Reese, S. In vivo confocal microscopy in the normal corneas of cats, dogs and birds. Veterinary Ophthalmology. American College of Veterinary Ophthalmologists (ACVO). N.10, pp 222-230. 2007.
Kim, J.Y.; Choi, M.Y.; Jeong, S.W.; Williams, D.L. Effect of bovine freeze-dried amniotic membrane (Amnisite-BATM) on uncomplicated canine corneal erosion. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.12. n.1, p.36-42, 2009.
Kim, J.T.; Chun, Y.S.; Song, G.Y.; Kim, J.Ch. The effect of In Vivo Grown Corneal Epithelium Transplantation on Persistent Epithelial Defects with Limbal Stem Cell Deficiency. Journal Korean Medicine Science, The Korean Academy of Medical Science, n.23, p.502-508, 2008.
Laus, J.L. Oftalmologia clinica e cirúrgica em cães e em gatos. São Paulo, Brasil: Editorial Roca Ltda., 2009. p.69-75.
Ledbetter, E.C.; Munger, R.J.; Ring, R.D.; Scarlett, J.M. Efficacy of two chondroitin sulfate ophthalmic solutions in the therapy of spontaneous chronic corneal epithelial defects and ulcerative keratitis associated with bullous keratopathy in dogs. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.9,
n.2, p.77-87, 2006.
Ma, D.; Kuo, M-T.; Tsai, Y-J.; Chen, H-CJ.; Chen, X-L.; Wang, L.L.; Hsiao, C-H.; Lin, K-K. Transplantation of cultivated oral mucosal epithelial cells for severe corneal burn. Clinical study. Eye. Macmillan Publishers Limited. N.23, .1442-1450, 2009.
Marfurt, C.F.; Murphy, C.J.; Florczak, J.L. Morphology and Neurochemistry of Canine Corneal Innervation. Investigation Ophthalmology Visual Science, v.42, n.10, p.2242-2251, 2001.
Montiani-Ferreira, F. Petersen-Jones, S. Cassotis, N. Ramsey, D. Gearhart, P. Cardoso, F. Early postnatal development of central thickness in dogs. Veterinary Ophthalmology. American College of Veterinary Ophthalmologists (ACVO). Vol. 6, N.1, pp 19-22. 2003.
Moore, P.A. Diagnosis and Management of Chronic Corneal Epithelial Defects (Indolent Corneal Ulcerations). Clinical Techniques in Small Animal Practice, United States. Ed. Mosby Elsevier. V.18, n.3, p.168-177, 2003.
Müller, L. Marfurt, C. Kruse, F. Tervo, T. Review. Corneal nerves: structure, contents and function. Experimental Eye Research. United States. Ed Elsevier Science Ltd.. N.76, pp 521-542. 2003.
Murphy, C.; Marfurt, C.F.; McDermott, A.; Bentley, E.; Abrams, G.A.; Reid, T.W.; Campbell, S. Spontaneous Chronic Corneal Epithelial Defects (SCCED) in Dogs: Clinical Features, Innervation, and Effect of Topical SP, with or without IGF-1. Investigative Ophthalmology & Visual Science (IOVS), Association for Research in Vision and Ophthalmology. V.42, n.10, p.2252-2261, 2001.
Myrna, K. Pot, S. Murphy, C. Meet the corneal myofibroblast: the role of myofibroblast transformation in corneal wound healing and pathology. Review. Veterinary Ophthalmology. American College of Veterinary Ophthalmologists (ACVO). V. 12, Supplement 1, pp 25-35. 2009.
Nagayasu, A.; Hosaka, Y.; Yamasaki, A.; Tsuzuki, K.; Ueda, H.; Honda, T.; Takehana, K. A Preliminary Study of Direct Application of Atelocollagen into a Wound Lesion in the Dog Cornea. Current Eye Research, Informa healthcare. United States. Ed. Taylor & Francis ltd. V.22, p.727-735, 2008.
Ollivier, F.J.; Gilger, B.C.; Barrie, K.P.; Kallberg, M.E.; Plummer, C.E.; O’Reilly, S.; Gelatt, K.N.; Brooks, D.E. Proteinases of the cornea and preocular tear film. Invited Review. Veterinary Ophthalmology, American College of Veterinary Ophthalmologist (ACVO), v.10, n.4, p.199-206., 2007.
Ollivier, F.J.; Kallberg, M.E.; Plummer, C.E.; Barrier, K.P.; O´Reilly, S.; Taylor, D.P.; Gelatt, K.N.; Brooks, D.E. Amniotic membrane transplantation for corneal surface reconstruction after excision of corneolimbal squamous cell carcinomas in nine horses. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.9, n.6, p.404-413, 2006.
Ollivier, F.J. Medical and Surgical Management of Melting Corneal Ulcers Exhibiting Hyperproteinase Activity in the Horse. Clinical Techniques in Equine Practice. Ed. Elsevier Saunders. n.4, p.50-71, 2005.
Pal-Ghosh, S. Pajoohesh-Ganji, A. Brown, M. Ann, M. A Mouse Model for the Study of Recurrent Corneal Epithelial Erosions: α9β1 Integrin Implicated in Progression of the Disease. Investigation Ophthalmology Visual Science, v.45, n.6, p.1775-1788, 2004.
Plummer, C.E. Review. The use of amniotic membrane transplantation for ocular surface reconstruction: a review and series of 58 equine clinical cases (2002-2008). Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), n.12, suppl.1, p.17-24, 2009.
Regnier, A.; Cazalot, G.; Cantaloube, B. Topical treatment of non-healing corneal epithelial ulcers in dogs with aminocaproic acid. Vet. Rec., v.157, n.17, p.510-513, 2006.
Sampaio, R.L.; Ranzani, J.J.T.; Rodrigues Junior, V.; Stacciarini, M.S.; Braga, E.M.; Borrezzi, C. Aspectos clinicos e imunopatológicos da ceratoplastia com membrana amniotica xenógena fresca e conservada em glicerina. Estudo experimental em coelhos. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v.58, n.6, p.1077-1085, 2006.
Slatter, D. Fundamentos de oftalmologia veterinária. 3.ed. São Paulo, Brasil: Editorial Roca Ltda., 2005. p.283-339.
Stanley, R.G.; Hardman, Ch.; Johnson, B.W. Results of grid keratotomy, superficial keratotomy and debridement for the management of persistent corneal erosion in 92 dogs. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), n.1, p.233-238, 1998.
Teixeira, R.B.; Barros, P.S.M.; Martins, M.C. Effects of topical 2% cyclosporine A on the corneas of dogs subjected to lamellar keratoplasty with a graft of equine pericardium preserved in glycerin: clinical and morphological evaluation. Ciência Rural, v.34, n.1, p.131-138, 2004.
Tsuzuki, K.; Yamashita, K.; Izumisawa, Y.; Kotani, T. Microstructure and glycosaminoglycan ratio of canine cornea after reconstructive transplantation with glycerin-preserved porcine amniotic membranes. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.11, n.4, p.222-227, 2008.
Vestre, W.A. Olho. Cornea. En: Bojrab, M.J.; Birchard, S.J.; Tomlinson, J.L. Técnicas Atuais em Cirurgia de Pequenos Animais. 3.ed. São Paulo, Brasil: Editorial Roca Ltda., 1996. pp, ---.
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Werner, A.; Braun, M.; Kietzmann, M. Isolation and cultivation of canine corneal cells for in vitro studies on the anti-inflamatory effects of dexamethasone. Veterinary Ophthalmology, American College of Veterinary Ophthalmologists (ACVO), v.11, n.2, p.67-74, 2008.
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